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TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165100((R)-(2,5-Dichloro-thiophen-3-yl)-[(4aR,5S)-1-(4-fl...)
Affinity DataEC50:  120nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19223((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  18nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165101((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  38nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19223((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  54nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  5.70nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19224(CHEMBL372684 | (S)-[(4aR,5S)-1-(4-fluorophenyl)-4a...)
Affinity DataEC50:  6nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19224(CHEMBL372684 | (S)-[(4aR,5S)-1-(4-fluorophenyl)-4a...)
Affinity DataEC50:  11nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  23nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19210((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Affinity DataEC50:  3.70nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  21nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19202(CHEMBL310570 | (1S)-1-[(4aR,5S)-1-(4-fluorophenyl)...)
Affinity DataEC50:  36nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  4.44E+3nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19210((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19220((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  42nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19202(CHEMBL310570 | (1S)-1-[(4aR,5S)-1-(4-fluorophenyl)...)
Affinity DataEC50:  0.960nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165105((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  21nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165101((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  215nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165106((R)-(5-Chloro-thiophen-2-yl)-[(4aR,5S)-1-(4-fluoro...)
Affinity DataEC50:  34nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19199((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  14.4nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165103((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  45nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19220((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  1.21E+3nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19192(BMCL173354 benzo[f]indazole, 6 | (R)-[(4aR,5S)-1-(...)
Affinity DataEC50:  22nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19224(CHEMBL372684 | (S)-[(4aR,5S)-1-(4-fluorophenyl)-4a...)
Affinity DataEC50:  3nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19210((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Affinity DataEC50:  3.20nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19202(CHEMBL310570 | (1S)-1-[(4aR,5S)-1-(4-fluorophenyl)...)
Affinity DataEC50:  5.20nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19224(CHEMBL372684 | (S)-[(4aR,5S)-1-(4-fluorophenyl)-4a...)
Affinity DataEC50:  356nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165106((R)-(5-Chloro-thiophen-2-yl)-[(4aR,5S)-1-(4-fluoro...)
Affinity DataEC50:  13nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  5nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19199((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  15nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165106((R)-(5-Chloro-thiophen-2-yl)-[(4aR,5S)-1-(4-fluoro...)
Affinity DataEC50:  1.07E+3nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165106((R)-(5-Chloro-thiophen-2-yl)-[(4aR,5S)-1-(4-fluoro...)
Affinity DataEC50:  17nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165105((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  37nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165104((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  260nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165104((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  12nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19199((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  521nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19192(BMCL173354 benzo[f]indazole, 6 | (R)-[(4aR,5S)-1-(...)
Affinity DataEC50:  9.70nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19202(CHEMBL310570 | (1S)-1-[(4aR,5S)-1-(4-fluorophenyl)...)
Affinity DataEC50:  8.30nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165103((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  2.70nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165104((R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)
Affinity DataEC50:  13nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19210((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Affinity DataEC50:  17nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  4.5nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165100((R)-(2,5-Dichloro-thiophen-3-yl)-[(4aR,5S)-1-(4-fl...)
Affinity DataEC50:  31nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19220((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  19nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  24nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50260908(3-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-...)
Affinity DataEC50:  3.60E+3nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50260939(3-(3-Chloro-3'-methanesulfonyl-biphenyl-4-yl)-5-[1...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50260937(3-(3-Chloro-4'-methanesulfonyl-biphenyl-4-yl)-5-[1...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50261050(3-(3-Chloro-3'-ethanesulfonyl-biphenyl-4-yl)-5-[1-...)
Affinity DataEC50:  2.50E+4nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50261010(3-(3-Chloro-2'-ethanesulfonyl-biphenyl-4-yl)-5-[1-...)
Affinity DataEC50:  700nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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