Compile Data Set for Download or QSAR
Found 198 with Last Name = 'bayrakdarian' and Initial = 'm'
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataIC50:  0.600nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataIC50:  6nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16060((2R,3R)-3-[(1S,2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4...)
Affinity DataIC50: <10nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16055((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16049((4S)-4-[(2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16054((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16057((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50:  10nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16048((4S)-4-amino-4-{[(1S)-1-{[(1S)-2-carbamoyl-1-{[(1R...)
Affinity DataIC50:  12nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340753(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50177433(CHEMBL535160 | N-(4-carbamimidoylbenzyl)-2-(2-hydr...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16049((4S)-4-[(2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S...)
Affinity DataIC50:  16nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50177436(CHEMBL557787 | N-(4-carbamimidoyl-benzyl)-2-[2-hyd...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340743(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340744(CHEMBL1762699 | N-benzyl-2-(4-(2-(4-chlorophenethy...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379718(CHEMBL2011127)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50235535(CHEMBL559192 | N-(4-carbamimidoyl-benzyl)-2-[4-met...)
Affinity DataIC50:  23nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379716(CHEMBL2011125)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379717(CHEMBL2011126)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340745(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50177425(CHEMBL537420 | N-(4-carbamimidoylbenzyl)-2-(3-(2,5...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16055((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50:  25nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16053((2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S)-2-acet...)
Affinity DataIC50:  25nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379714(CHEMBL2011123)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16051((4S)-4-amino-4-{[(1S)-1-{[(1S)-2-carbamoyl-1-{[(1S...)
Affinity DataIC50:  39nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50177421(CHEMBL558235 | N-(4-carbamimidoylbenzyl)-2-(3-(3,4...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340746(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16050((2S)-2-[(2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S...)
Affinity DataIC50:  40nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50177419(CHEMBL557779 | N-(4-carbamimidoylbenzyl)-2-(2-hydr...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16057((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50:  56nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16056((1R,2R)-N-butyl-2-[(1S,2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataIC50:  60nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16050((2S)-2-[(2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S...)
Affinity DataIC50:  60nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379707(CHEMBL2011112)
Affinity DataIC50:  61nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379719(CHEMBL2011118)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379736(CHEMBL2011116)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50379711(CHEMBL2011120)
Affinity DataIC50:  69nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16060((2R,3R)-3-[(1S,2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4...)
Affinity DataIC50:  70nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340750(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  77nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50177430(CHEMBL541383 | N-(4-carbamimidoylbenzyl)-2-(3-(4-c...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
AstraZeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50340747(2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)pip...)
Affinity DataIC50:  88nMAssay Description:Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16052((2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S)-2-acet...)
Affinity DataIC50:  90nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
EPIGENETIX, INC.

US Patent
LigandPNGBDBM449849(5-[2-cyclobutyl-3-[2-(trifluoromethoxy)ethyl]benzi...)
Affinity DataIC50:  91nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50235527(CHEMBL535639 | N-(4-carbamimidoylbenzyl)-2-(4-meth...)
Affinity DataIC50:  91nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Neomed Institute

US Patent
LigandPNGBDBM449849(5-[2-cyclobutyl-3-[2-(trifluoromethoxy)ethyl]benzi...)
Affinity DataIC50:  91nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50235519(2-(1-(2,5-dimethylphenethylamino)-4-methyl-2-oxo-1...)
Affinity DataIC50:  92nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£ de Montr£al

Curated by ChEMBL
LigandPNGBDBM50177420(CHEMBL534714 | N-(4-carbamimidoylbenzyl)-2-(2-hydr...)
Affinity DataIC50:  97nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Neomed Institute

US Patent
LigandPNGBDBM449854(5-[3-[(1R)-2-methoxy-1-methyl-ethyl]-2-methyl-benz...)
Affinity DataIC50:  98nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
EPIGENETIX, INC.

US Patent
LigandPNGBDBM449854(5-[3-[(1R)-2-methoxy-1-methyl-ethyl]-2-methyl-benz...)
Affinity DataIC50:  98nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Universite de Montreal at Succursale Centre-Ville

LigandPNGBDBM16048((4S)-4-amino-4-{[(1S)-1-{[(1S)-2-carbamoyl-1-{[(1R...)
Affinity DataIC50:  98nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
EPIGENETIX, INC.

US Patent
LigandPNGBDBM449853(5-[3-[(1R)-2-methoxy-1-methyl-ethyl]-2-tetrahydrop...)
Affinity DataIC50:  99nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Neomed Institute

US Patent
LigandPNGBDBM449853(5-[3-[(1R)-2-methoxy-1-methyl-ethyl]-2-tetrahydrop...)
Affinity DataIC50:  99nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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