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TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321415(6-[(E)-but-2-enyl]-2-methyl-4-[3-methyl-4-(morphol...)
Affinity DataEC50:  35nMAssay Description:Binding affinity to ZsGreen fused-BRD9 (M1 to T597 residues) (unknown origin) expressed in human U2OS-C433 cells assessed as induction of protein bro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 7(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd:  110nMAssay Description:Binding affinity to human partial length BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545732(CHEMBL4638408)
Affinity DataEC50:  362nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM394530(US10308614, Example 131 | (R)-1-(4-(3-amino-6-(2-)
Affinity DataKd:  16nMAssay Description:Binding affinity to human SMARCA2 (S1337 to Q1486 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRD2 bromodomain 2 isoform 1 (E348 to D455 residues) expressed in bacterial expression system by BROMOscan a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 7(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50269687(CHEMBL4073178)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to human DNA-tagged BRD7 (125 to 254 residues) expressed in mammalian expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPeregrin(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613459(CHEMBL5287013)
Affinity DataEC50:  250nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613469(CHEMBL5279452)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd:  410nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd:  310nMAssay Description:Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain testis-specific protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to human partial length BRDT bromodomain 1 (N21 to E137 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50072035(CHEMBL3407861)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of PERK-mediated protein synthesis in human U2OS cells harboring thapsigargin-induced ER stress assessed as incorporation of L-azidohomoal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd:  25nMAssay Description:Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain testis-specific protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to BRDT bromodomain 1/2 (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50269687(CHEMBL4073178)
Affinity DataEC50:  370nMAssay Description:Binding affinity to ZsGreen fused-CECR2 bromodomain (M404 to H515 residues) (unknown origin) expressed in human U2OS-C433 cells co expressing (MDPKKK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326208(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)
Affinity DataEC50:  24nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetTranscription activator BRG1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50598934(CHEMBL5183240)
Affinity DataKd:  510nMAssay Description:Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProbable global transcription activator SNF2L2(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM394583(US10308614, Example 186 | 2-(6-amino-5-phenylpyrid...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human MHHHHHHGSLVPRGS-tagged SMARAC2 isoform B L1412P/P1413V/S1414N mutant (S1377 to Q1486 residues) by isothermal titration calo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to BRD3 bromodomain 1/2 (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetTranscription activator BRG1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataEC50:  520nMAssay Description:Inhibition of PERK-mediated protein synthesis in human U2OS cells harboring thapsigargin-induced ER stress assessed as incorporation of L-azidohomoal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein polybromo-1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50598934(CHEMBL5183240)
Affinity DataKd:  580nMAssay Description:Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613461(CHEMBL5274793)
Affinity DataEC50:  170nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone acetyltransferase p300(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321437((E)-6-(but-2-en-1-yl)-4-(4-(2-hydroxypropan-2-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetNucleosome-remodeling factor subunit BPTF(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length FALZ (S2791 to H2911 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545729(CHEMBL4646795)
Affinity DataEC50:  52nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM321437((E)-6-(but-2-en-1-yl)-4-(4-(2-hydroxypropan-2-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to BRD4 bromodomain 1/2 long isoform (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProtein polybromo-1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 1 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human partial length BRD2 bromodomain 1 long isoform (K71 to N194 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProtein polybromo-1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM394530(US10308614, Example 131 | (R)-1-(4-(3-amino-6-(2-)
Affinity DataKd:  18nMAssay Description:Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProtein polybromo-1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50598935(CHEMBL5194650)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563825(CHEMBL4794859)
Affinity DataEC50:  20nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326210(2-(4-Fluorophenylamino)-N-(4-(3-(2-(methylamino)py...)
Affinity DataEC50:  28nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50072071(CHEMBL3407855)
Affinity DataEC50:  5.60E+3nMAssay Description:Inhibition of PERK-mediated protein synthesis in human U2OS cells harboring thapsigargin-induced ER stress assessed as incorporation of L-azidohomoal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545734(CHEMBL4647263)
Affinity DataEC50:  312nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM321437((E)-6-(but-2-en-1-yl)-4-(4-(2-hydroxypropan-2-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to BRD3 bromodomain 1/2 (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBromodomain-containing protein 8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to BRD8 bromodomain 1 (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPeregrin(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50178170(CHEMBL3814881)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50410150(CHEMBL2096774)
Affinity DataEC50:  128nMAssay Description:Effective concentration for DP2 mediated chemotaxis in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
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