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TargetSalicyl-AMP ligase / salicyl-S-ArCP synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50244934(5'-O-[N-(2-Hydroxybenzoyl)sulfamoyl]-2-phenyladeno...)
Affinity DataKd:  0.000260nMAssay Description:Binding affinity to Mycobacterium tuberculosis recombinant MbtA using saturated levels of salicylic acid substrate by isothermal calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394184(CHEMBL2158860)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394176(CHEMBL2158861)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394177(CHEMBL2158862)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394185(CHEMBL2158864)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394175(CHEMBL2158858)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300067(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394165(CHEMBL2158866)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300072(methyl 4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300077(ethyl 4-(6-(4-(3-ethylureido)phenyl)-4-morpholino-...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300070(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300071(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300075(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394164(CHEMBL2158011)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394174(CHEMBL2158863)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300066(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300078(methyl 4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300069(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300080((R)-ethyl 4-(4-(3-methylmorpholino)-6-(4-(3-pyridi...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35589(pyrazolo pyrimidine, 21)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35578(pyrazolo pyrimidine, 10)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300068(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300097(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300076(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300084((S)-ethyl 4-(4-(3-methylmorpholino)-6-(4-(3-pyridi...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300081(1-(2-fluoroethyl)-3-(4-(4-morpholino-1-(2,2,2-trif...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300079(methyl 4-(4-(2-methylmorpholino)-6-(4-(3-pyridin-3...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300082(methyl 4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300095(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300073((R)-ethyl 4-(6-(4-(3-ethylureido)phenyl)-4-(3-meth...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300085(1-methyl-3-(4-(4-morpholino-1-(2,2,2-trifluoroethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300086((R)-ethyl 4-(6-(4-(3-(2-fluoroethyl)ureido)phenyl)...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300098(1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300083((S)-ethyl 4-(6-(4-(3-ethylureido)phenyl)-4-(3-meth...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300096((S)-ethyl 4-(6-(4-(3-(2-fluoroethyl)ureido)phenyl)...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300089(1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300090(methyl 4-(6-(4-(3-ethylureido)phenyl)-4-(2-methylm...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300087(methyl 4-(4-(2-methylmorpholino)-6-(4-(3-methylure...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394181(CHEMBL2158857)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394186(CHEMBL2158853)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394186(CHEMBL2158853)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65549(cid_644215 | 3-[[4-[2-(3-chloroanilino)pyrimidin-4...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65549(cid_644215 | 3-[[4-[2-(3-chloroanilino)pyrimidin-4...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300088(1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394180(CHEMBL2158855)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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