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TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Ponce De Leon Health

Curated by ChEMBL
LigandPNGBDBM50378137(Ketek | TELITHROMYCIN)
Affinity DataEC50:  1.32E+5nMAssay Description:Inhibition of human alpha3beta4 nAChR assessed as increase in acetylcholine-induced normalized current at 2 uM (Rvb = 78.5 +/- 10 uM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50414372(CHEMBL2145458)
Affinity DataKd:  5.00E+4nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  4.40E+3nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as evoked ACh-induced current by voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataEC50:  8.70E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataEC50:  6.90E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte in presence of 6 uM (S)-ethyl 1-(2-cyanoethyl)pyrrolidine-2-carboxylat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353944(CHEMBL1831036)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353945(CHEMBL1831033)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353946(CHEMBL1831032)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353947(CHEMBL1831030)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353948(CHEMBL1831043)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353949(CHEMBL1831038)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419175(CHEMBL1831034)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419184(CHEMBL1831046)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419182(CHEMBL1831044)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419181(CHEMBL1831042)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419179(CHEMBL1831035)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at alpha4beta 2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at alpha4beta 2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50166908(CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...)
Affinity DataEC50:  0.0600nMAssay Description:Partial agonist activity at alpha4beta 2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267844(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylox...)
Affinity DataIC50: 210nMAssay Description:Activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked currentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267883(8-Benzyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohept...)
Affinity DataIC50: 460nMAssay Description:Activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked currentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267844(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylox...)
Affinity DataIC50: 880nMAssay Description:Activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked currentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267883(8-Benzyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohept...)
Affinity DataIC50: 1.73E+3nMAssay Description:Activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked currentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50389167(CHEMBL2062610)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339001((S)-4-bromophenyl hexahydro-1H-pyrrolo[1,2-a][1,4]...)
Affinity DataIC50: 5.60E+3nMAssay Description:Competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp meth...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339001((S)-4-bromophenyl hexahydro-1H-pyrrolo[1,2-a][1,4]...)
Affinity DataIC50: 5.60E+3nMAssay Description:Competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by elec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339002(((3S,9aR)-hexahydro-3-methyl-1H-pyrido[1,2-a]pyraz...)
Affinity DataIC50: 6.10E+3nMAssay Description:Non competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339002(((3S,9aR)-hexahydro-3-methyl-1H-pyrido[1,2-a]pyraz...)
Affinity DataIC50: 6.10E+3nMAssay Description:Non-competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50389163(CHEMBL2064771)
Affinity DataIC50: 6.90E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339003((4-chlorophenyl)(4-isopropyl-1,4-diazocan-1-yl)met...)
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339003((4-chlorophenyl)(4-isopropyl-1,4-diazocan-1-yl)met...)
Affinity DataIC50: 7.00E+3nMAssay Description:Mixed antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339004(4-chloro-N-((hexahydro-1H-pyrrolizin-7a-yl)methyl)...)
Affinity DataIC50: 7.20E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50339004(4-chloro-N-((hexahydro-1H-pyrrolizin-7a-yl)methyl)...)
Affinity DataIC50: 7.20E+3nMAssay Description:Mixed antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50389164(CHEMBL2062602)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50294731((S)-2-(3-aminobutanamido)acetic acid | CHEMBL55388...)
Affinity DataIC50: 2.80E+4nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50389165(CHEMBL2062604)
Affinity DataIC50: 4.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50389166(CHEMBL2062605)
Affinity DataIC50: 4.50E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50294730(2-(4-aminobutanamido)acetic acid | CHEMBL557092)
Affinity DataIC50: 6.50E+4nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50414372(CHEMBL2145458)
Affinity DataIC50: 3.70E+5nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Louis Pasteur University

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.180nMAssay Description:Binding affinity towards alpha4-beta2 nicotinic receptor was determined in rat brain membrane using [3H]cytisine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Louis Pasteur University

Curated by ChEMBL
LigandPNGBDBM50125187(2-(2-Chloro-pyrimidin-5-yl)-7-aza-bicyclo[2.2.1]he...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity towards alpha4-beta2 nicotinic receptor was determined in rat brain membrane using [3H]cytisine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Louis Pasteur University

Curated by ChEMBL
LigandPNGBDBM50125188(N-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-yl]...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards alpha4-beta2 nicotinic receptor was determined in rat brain membrane using [3H]cytisine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  63.1nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM50267844(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylox...)
Affinity DataKi:  63.1nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM50267883(8-Benzyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohept...)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM50413516(CHEMBL522249)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM50413513(CHEMBL452172)
Affinity DataKi:  126nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM50413514(CHEMBL522981)
Affinity DataKi:  126nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM50419188(CHEMBL1616460)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-epibatidine from histidine-tagged Lymnaea stagnalis AChBP expressed in Sf9 cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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