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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445224(US10669235, Example 15)
Affinity DataKi:  2.5nMAssay Description:The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  2.5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50372007(CHEMBL257017)
Affinity DataKi:  3nMAssay Description:Binding affinity to CXCR3 receptor expressed in CHO cells assessed as ITAC-induced [35]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50227864(1-(1-((9-acetyl-9-aza-bicyclo[3.3.1]non-2-en-3-yl)...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at human CXCR3 by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445247(US10669235, Example 38 | US11208381, Example 38)
Affinity DataKi:  3.26nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445247(US10669235, Example 38 | US11208381, Example 38)
Affinity DataKi:  3.26nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445242(US10669235, Example 33 | US11208381, Example 33)
Affinity DataKi:  3.56nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445242(US10669235, Example 33 | US11208381, Example 33)
Affinity DataKi:  3.56nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445257(US10669235, Example 48 | US11208381, Example 48)
Affinity DataKi:  3.68nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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LigandPNGBDBM445257(US10669235, Example 48 | US11208381, Example 48)
Affinity DataKi:  3.68nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKi:  3.80nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKi:  3.80nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445209(US10669235, Nintedanib)
Affinity DataKi:  3.80nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507109(US11046672, Example 58)
Affinity DataKi:  3.86nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50372000(CHEMBL256851)
Affinity DataKi:  4nMAssay Description:Binding affinity to CXCR3 receptor expressed in CHO cells assessed as ITAC-induced [35]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445255(US10669235, Example 46 | US11208381, Example 46)
Affinity DataKi:  4.15nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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LigandPNGBDBM445255(US10669235, Example 46 | US11208381, Example 46)
Affinity DataKi:  4.15nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507056((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Affinity DataKi:  4.57nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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LigandPNGBDBM507078(US11046672, Example 27)
Affinity DataKi:  4.77nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445247(US10669235, Example 38 | US11208381, Example 38)
Affinity DataKi:  4.79nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445247(US10669235, Example 38 | US11208381, Example 38)
Affinity DataKi:  4.79nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445240(US10669235, Example 31 | US11208381, Example 31)
Affinity DataKi:  4.83nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445240(US10669235, Example 31 | US11208381, Example 31)
Affinity DataKi:  4.83nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507083(US11046672, Example 32)
Affinity DataKi:  4.92nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445240(US10669235, Example 31 | US11208381, Example 31)
Affinity DataKi:  4.96nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445240(US10669235, Example 31 | US11208381, Example 31)
Affinity DataKi:  4.96nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50372006(CHEMBL256850)
Affinity DataKi:  5nMAssay Description:Binding affinity to CXCR3 receptor expressed in CHO cells assessed as ITAC-induced [35]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445224(US10669235, Example 15)
Affinity DataKi:  5nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445224(US10669235, Example 15)
Affinity DataKi:  5nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445224(US10669235, Example 15)
Affinity DataKi:  5nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM531233((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...)
Affinity DataKi:  5nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445241(US10669235, Example 32 | US11208381, Example 32)
Affinity DataKi:  5.02nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445241(US10669235, Example 32 | US11208381, Example 32)
Affinity DataKi:  5.02nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445220(US10669235, Example 11 | US11208381, Example 11)
Affinity DataKi:  5.06nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445220(US10669235, Example 11 | US11208381, Example 11)
Affinity DataKi:  5.06nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507111(US11046672, Example 60)
Affinity DataKi:  5.24nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445226(US10669235, Example 17 | US11208381, Example 17)
Affinity DataKi:  5.31nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445226(US10669235, Example 17 | US11208381, Example 17)
Affinity DataKi:  5.31nMAssay Description:The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507108(US11046672, Example 57)
Affinity DataKi:  5.36nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507090(US11046672, Example 39)
Affinity DataKi:  5.39nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507110(US11046672, Example 59)
Affinity DataKi:  5.43nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445223(US10669235, Example 14 | US10669235, Example 50 | ...)
Affinity DataKi:  5.51nMAssay Description:The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...More data for this Ligand-Target Pair
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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445223(US10669235, Example 14 | US10669235, Example 50 | ...)
Affinity DataKi:  5.51nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445223(US10669235, Example 14 | US10669235, Example 50 | ...)
Affinity DataKi:  5.51nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445223(US10669235, Example 14 | US10669235, Example 50 | ...)
Affinity DataKi:  5.51nMAssay Description:The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM507113(US11046672, Example 62)
Affinity DataKi:  5.74nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445216(US10669235, Example 7 | US11208381, Example 7)
Affinity DataKi:  5.76nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
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US Patent
LigandPNGBDBM445216(US10669235, Example 7 | US11208381, Example 7)
Affinity DataKi:  5.76nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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