Compile Data Set for Download or QSAR
Found 204 with Last Name = 'bjurling' and Initial = 'e'
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306222(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(4-f...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(O)(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C29H25Cl2FN4O3/c30-20-9-5-18(6-10-20)27-22(17-25(33)37)26(34-36(27)24-4-2-1-3-23(24)31)28(38)35-15-13-29(39,14-16-35)19-7-11-21(32)12-8-19/h1-12,39H,13-17H2,(H2,33,37)
Affinity DataIC50: 0.100nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306234(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-cyan...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)(C#N)c1ccccc1
Show InChI InChI=1S/C30H25Cl2N5O2/c31-22-12-10-20(11-13-22)28-23(18-26(34)38)27(35-37(28)25-9-5-4-8-24(25)32)29(39)36-16-14-30(19-33,15-17-36)21-6-2-1-3-7-21/h1-13H,14-18H2,(H2,34,38)
Affinity DataIC50: 0.110nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306235(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-hydr...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C29H26Cl2N4O3/c30-21-12-10-19(11-13-21)27-22(18-25(32)36)26(33-35(27)24-9-5-4-8-23(24)31)28(37)34-16-14-29(38,15-17-34)20-6-2-1-3-7-20/h1-13,38H,14-18H2,(H2,32,36)
Affinity DataIC50: 0.110nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306222(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(4-f...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(O)(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C29H25Cl2FN4O3/c30-20-9-5-18(6-10-20)27-22(17-25(33)37)26(34-36(27)24-4-2-1-3-23(24)31)28(38)35-15-13-29(39,14-16-35)19-7-11-21(32)12-8-19/h1-12,39H,13-17H2,(H2,33,37)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305440(2-(3-(5-bromoisoindoline-2-carbonyl)-1-(2-chloroph...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)N1Cc2ccc(Br)cc2C1
Show InChI InChI=1S/C26H17BrCl2N4O/c27-19-8-5-17-14-32(15-18(17)13-19)26(34)24-21(11-12-30)25(16-6-9-20(28)10-7-16)33(31-24)23-4-2-1-3-22(23)29/h1-10,13H,11,14-15H2
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306234(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-cyan...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)(C#N)c1ccccc1
Show InChI InChI=1S/C30H25Cl2N5O2/c31-22-12-10-20(11-13-22)28-23(18-26(34)38)27(35-37(28)25-9-5-4-8-24(25)32)29(39)36-16-14-30(19-33,15-17-36)21-6-2-1-3-7-21/h1-13H,14-18H2,(H2,34,38)
Affinity DataIC50: 0.230nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306235(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-hydr...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C29H26Cl2N4O3/c30-21-12-10-19(11-13-21)27-22(18-25(32)36)26(33-35(27)24-9-5-4-8-23(24)31)28(37)34-16-14-29(38,15-17-34)20-6-2-1-3-7-20/h1-13,38H,14-18H2,(H2,32,36)
Affinity DataIC50: 0.260nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306225(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(pyr...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)c1ncccn1
Show InChI InChI=1S/C27H24Cl2N6O2/c28-19-8-6-17(7-9-19)25-20(16-23(30)36)24(33-35(25)22-5-2-1-4-21(22)29)27(37)34-14-10-18(11-15-34)26-31-12-3-13-32-26/h1-9,12-13,18H,10-11,14-16H2,(H2,30,36)
Affinity DataIC50: 0.300nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306232(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NCC1CCN(CC1)C#N
Show InChI InChI=1S/C25H24Cl2N6O2/c26-18-7-5-17(6-8-18)24-19(13-22(29)34)23(31-33(24)21-4-2-1-3-20(21)27)25(35)30-14-16-9-11-32(15-28)12-10-16/h1-8,16H,9-14H2,(H2,29,34)(H,30,35)
Affinity DataIC50: 0.340nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306215(4-(2-amino-2-iminoethyl)-1-(2-chlorophenyl)-5-(4-c...)
Show SMILES NC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H24Cl2N6O/c24-16-10-8-15(9-11-16)22-17(14-20(26)27)21(23(32)29-30-12-4-1-5-13-30)28-31(22)19-7-3-2-6-18(19)25/h2-3,6-11H,1,4-5,12-14H2,(H3,26,27)(H,29,32)
Affinity DataIC50: 0.400nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305415(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(cyanometh...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)NC1CCc2ccccc12
Show InChI InChI=1S/C27H20Cl2N4O/c28-19-12-9-18(10-13-19)26-21(15-16-30)25(32-33(26)24-8-4-3-7-22(24)29)27(34)31-23-14-11-17-5-1-2-6-20(17)23/h1-10,12-13,23H,11,14-15H2,(H,31,34)
Affinity DataIC50: 0.410nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306232(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NCC1CCN(CC1)C#N
Show InChI InChI=1S/C25H24Cl2N6O2/c26-18-7-5-17(6-8-18)24-19(13-22(29)34)23(31-33(24)21-4-2-1-3-20(21)27)25(35)30-14-16-9-11-32(15-28)12-10-16/h1-8,16H,9-14H2,(H2,29,34)(H,30,35)
Affinity DataIC50: 0.490nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305422(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(cyanometh...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)NC1CCCCCC1
Show InChI InChI=1S/C25H24Cl2N4O/c26-18-13-11-17(12-14-18)24-20(15-16-28)23(25(32)29-19-7-3-1-2-4-8-19)30-31(24)22-10-6-5-9-21(22)27/h5-6,9-14,19H,1-4,7-8,15H2,(H,29,32)
Affinity DataIC50: 0.490nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306220(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(2-f...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)c1ccccc1F
Show InChI InChI=1S/C29H25Cl2FN4O2/c30-20-11-9-19(10-12-20)28-22(17-26(33)37)27(34-36(28)25-8-4-2-6-23(25)31)29(38)35-15-13-18(14-16-35)21-5-1-3-7-24(21)32/h1-12,18H,13-17H2,(H2,33,37)
Affinity DataIC50: 0.510nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305403(CHEMBL607031 | N-(4-bromo-2-fluorobenzyl)-1-(2-chl...)
Show SMILES Fc1cc(Br)ccc1CNC(=O)c1nn(c(c1CC#N)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C25H16BrCl2FN4O/c26-17-8-5-16(21(29)13-17)14-31-25(34)23-19(11-12-30)24(15-6-9-18(27)10-7-15)33(32-23)22-4-2-1-3-20(22)28/h1-10,13H,11,14H2,(H,31,34)
Affinity DataIC50: 0.510nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305423(CHEMBL606242 | N-(azepan-1-yl)-1-(2-chlorophenyl)-...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)NN1CCCCCC1
Show InChI InChI=1S/C24H23Cl2N5O/c25-18-11-9-17(10-12-18)23-19(13-14-27)22(24(32)29-30-15-5-1-2-6-16-30)28-31(23)21-8-4-3-7-20(21)26/h3-4,7-12H,1-2,5-6,13,15-16H2,(H,29,32)
Affinity DataIC50: 0.520nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306221(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(2-f...)
Show SMILES ONC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)c1ccccc1F
Show InChI InChI=1S/C29H26Cl2FN5O2/c30-20-11-9-19(10-12-20)28-22(17-26(33)35-39)27(34-37(28)25-8-4-2-6-23(25)31)29(38)36-15-13-18(14-16-36)21-5-1-3-7-24(21)32/h1-12,18,39H,13-17H2,(H2,33,35)
Affinity DataIC50: 0.540nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306231(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES Cc1ccncc1NC(=O)c1nn(c(c1CC(N)=O)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C24H19Cl2N5O2/c1-14-10-11-28-13-19(14)29-24(33)22-17(12-21(27)32)23(15-6-8-16(25)9-7-15)31(30-22)20-5-3-2-4-18(20)26/h2-11,13H,12H2,1H3,(H2,27,32)(H,29,33)
Affinity DataIC50: 0.550nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306226(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(pyr...)
Show SMILES NC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)c1ncccn1
Show InChI InChI=1S/C27H25Cl2N7O/c28-19-8-6-17(7-9-19)25-20(16-23(30)31)24(34-36(25)22-5-2-1-4-21(22)29)27(37)35-14-10-18(11-15-35)26-32-12-3-13-33-26/h1-9,12-13,18H,10-11,14-16H2,(H3,30,31)
Affinity DataIC50: 0.590nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306232(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NCC1CCN(CC1)C#N
Show InChI InChI=1S/C25H24Cl2N6O2/c26-18-7-5-17(6-8-18)24-19(13-22(29)34)23(31-33(24)21-4-2-1-3-20(21)27)25(35)30-14-16-9-11-32(15-28)12-10-16/h1-8,16H,9-14H2,(H2,29,34)(H,30,35)
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305404(CHEMBL590387 | N-(3-bromo-4-fluorobenzyl)-1-(2-chl...)
Show SMILES Fc1ccc(CNC(=O)c2nn(c(c2CC#N)-c2ccc(Cl)cc2)-c2ccccc2Cl)cc1Br
Show InChI InChI=1S/C25H16BrCl2FN4O/c26-19-13-15(5-10-21(19)29)14-31-25(34)23-18(11-12-30)24(16-6-8-17(27)9-7-16)33(32-23)22-4-2-1-3-20(22)28/h1-10,13H,11,14H2,(H,31,34)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306225(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(pyr...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)c1ncccn1
Show InChI InChI=1S/C27H24Cl2N6O2/c28-19-8-6-17(7-9-19)25-20(16-23(30)36)24(33-35(25)22-5-2-1-4-21(22)29)27(37)34-14-10-18(11-15-34)26-31-12-3-13-32-26/h1-9,12-13,18H,10-11,14-16H2,(H2,30,36)
Affinity DataIC50: 0.710nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306234(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-cyan...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)(C#N)c1ccccc1
Show InChI InChI=1S/C30H25Cl2N5O2/c31-22-12-10-20(11-13-22)28-23(18-26(34)38)27(35-37(28)25-9-5-4-8-24(25)32)29(39)36-16-14-30(19-33,15-17-36)21-6-2-1-3-7-21/h1-13H,14-18H2,(H2,34,38)
Affinity DataIC50: 0.780nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306230(4-(2-amino-2-iminoethyl)-1-(2-chlorophenyl)-5-(4-c...)
Show SMILES NC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C25H20Cl2FN5O/c26-17-9-7-16(8-10-17)24-19(13-22(29)30)23(32-33(24)21-4-2-1-3-20(21)27)25(34)31-14-15-5-11-18(28)12-6-15/h1-12H,13-14H2,(H3,29,30)(H,31,34)
Affinity DataIC50: 0.790nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306214(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H23Cl2N5O2/c24-16-10-8-15(9-11-16)22-17(14-20(26)31)21(23(32)28-29-12-4-1-5-13-29)27-30(22)19-7-3-2-6-18(19)25/h2-3,6-11H,1,4-5,12-14H2,(H2,26,31)(H,28,32)
Affinity DataIC50: 0.820nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306215(4-(2-amino-2-iminoethyl)-1-(2-chlorophenyl)-5-(4-c...)
Show SMILES NC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H24Cl2N6O/c24-16-10-8-15(9-11-16)22-17(14-20(26)27)21(23(32)29-30-12-4-1-5-13-30)28-31(22)19-7-3-2-6-18(19)25/h2-3,6-11H,1,4-5,12-14H2,(H3,26,27)(H,29,32)
Affinity DataIC50: 0.930nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305432(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(4-f...)
Show SMILES Fc1ccc(cc1)C1CCN(CC1)C(=O)c1nn(c(c1CC#N)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C29H23Cl2FN4O/c30-22-9-5-21(6-10-22)28-24(13-16-33)27(34-36(28)26-4-2-1-3-25(26)31)29(37)35-17-14-20(15-18-35)19-7-11-23(32)12-8-19/h1-12,20H,13-15,17-18H2
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306229(1-(2-chlorophenyl)-5-(4-chlorophenyl)-N-(4-fluorop...)
Show SMILES ONC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C24H18Cl2FN5O2/c25-15-7-5-14(6-8-15)23-18(13-21(28)31-34)22(24(33)29-17-11-9-16(27)10-12-17)30-32(23)20-4-2-1-3-19(20)26/h1-12,34H,13H2,(H2,28,31)(H,29,33)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305427(CHEMBL590132 | methyl 2-(1-(2-chlorophenyl)-5-(4-c...)
Show SMILES COC(=O)C(Cc1ccccc1)NC(=O)c1nn(c(c1CC#N)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C28H22Cl2N4O3/c1-37-28(36)23(17-18-7-3-2-4-8-18)32-27(35)25-21(15-16-31)26(19-11-13-20(29)14-12-19)34(33-25)24-10-6-5-9-22(24)30/h2-14,23H,15,17H2,1H3,(H,32,35)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306233(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(5-c...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C28H23Cl2N7O2/c29-20-8-6-19(7-9-20)27-21(15-24(32)38)26(34-37(27)23-4-2-1-3-22(23)30)28(39)36-13-11-35(12-14-36)25-10-5-18(16-31)17-33-25/h1-10,17H,11-15H2,(H2,32,38)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306239(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NC1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C27H27Cl2N5O3/c28-18-9-7-16(8-10-18)25-20(15-23(30)35)24(32-34(25)22-4-2-1-3-21(22)29)26(36)31-19-11-13-33(14-12-19)27(37)17-5-6-17/h1-4,7-10,17,19H,5-6,11-15H2,(H2,30,35)(H,31,36)
Affinity DataIC50: 1.20nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305397(CHEMBL589651 | N-(4-bromobenzyl)-1-(2-chlorophenyl...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)NCc1ccc(Br)cc1
Show InChI InChI=1S/C25H17BrCl2N4O/c26-18-9-5-16(6-10-18)15-30-25(33)23-20(13-14-29)24(17-7-11-19(27)12-8-17)32(31-23)22-4-2-1-3-21(22)28/h1-12H,13,15H2,(H,30,33)
Affinity DataIC50: 1.20nMAssay Description:Inverse agonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as stimulation of GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305396(CHEMBL590136 | N-(4-chlorobenzyl)-1-(2-chloropheny...)
Show SMILES Clc1ccc(CNC(=O)c2nn(c(c2CC#N)-c2ccc(Cl)cc2)-c2ccccc2Cl)cc1
Show InChI InChI=1S/C25H17Cl3N4O/c26-18-9-5-16(6-10-18)15-30-25(33)23-20(13-14-29)24(17-7-11-19(27)12-8-17)32(31-23)22-4-2-1-3-21(22)28/h1-12H,13,15H2,(H,30,33)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306230(4-(2-amino-2-iminoethyl)-1-(2-chlorophenyl)-5-(4-c...)
Show SMILES NC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C25H20Cl2FN5O/c26-17-9-7-16(8-10-17)24-19(13-22(29)30)23(32-33(24)21-4-2-1-3-20(21)27)25(34)31-14-15-5-11-18(28)12-6-15/h1-12H,13-14H2,(H3,29,30)(H,31,34)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306216(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(2-(hydrox...)
Show SMILES ONC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H24Cl2N6O2/c24-16-10-8-15(9-11-16)22-17(14-20(26)29-33)21(23(32)28-30-12-4-1-5-13-30)27-31(22)19-7-3-2-6-18(19)25/h2-3,6-11,33H,1,4-5,12-14H2,(H2,26,29)(H,28,32)
Affinity DataIC50: 1.30nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306225(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(pyr...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(CC1)c1ncccn1
Show InChI InChI=1S/C27H24Cl2N6O2/c28-19-8-6-17(7-9-19)25-20(16-23(30)36)24(33-35(25)22-5-2-1-4-21(22)29)27(37)34-14-10-18(11-15-34)26-31-12-3-13-32-26/h1-9,12-13,18H,10-11,14-16H2,(H2,30,36)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306233(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(5-c...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C28H23Cl2N7O2/c29-20-8-6-19(7-9-20)27-21(15-24(32)38)26(34-37(27)23-4-2-1-3-22(23)30)28(39)36-13-11-35(12-14-36)25-10-5-18(16-31)17-33-25/h1-10,17H,11-15H2,(H2,32,38)
Affinity DataIC50: 1.40nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306214(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H23Cl2N5O2/c24-16-10-8-15(9-11-16)22-17(14-20(26)31)21(23(32)28-29-12-4-1-5-13-29)27-30(22)19-7-3-2-6-18(19)25/h2-3,6-11H,1,4-5,12-14H2,(H2,26,31)(H,28,32)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306228(4-(2-amino-2-iminoethyl)-1-(2-chlorophenyl)-5-(4-c...)
Show SMILES NC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C24H18Cl2FN5O/c25-15-7-5-14(6-8-15)23-18(13-21(28)29)22(24(33)30-17-11-9-16(27)10-12-17)31-32(23)20-4-2-1-3-19(20)26/h1-12H,13H2,(H3,28,29)(H,30,33)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305424(CHEMBL599964 | trans-1-(2-chlorophenyl)-5-(4-chlor...)
Show SMILES C[C@H]1CC[C@@H](CC1)NC(=O)c1nn(c(c1CC#N)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C25H24Cl2N4O/c1-16-6-12-19(13-7-16)29-25(32)23-20(14-15-28)24(17-8-10-18(26)11-9-17)31(30-23)22-5-3-2-4-21(22)27/h2-5,8-11,16,19H,6-7,12-14H2,1H3,(H,29,32)/t16-,19-
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305401(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(cyanometh...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H16Cl4N4O/c26-17-8-5-15(6-9-17)24-19(11-12-30)23(32-33(24)22-4-2-1-3-20(22)28)25(34)31-14-16-7-10-18(27)13-21(16)29/h1-10,13H,11,14H2,(H,31,34)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305417(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(cyanometh...)
Show SMILES O[C@@H]1Cc2ccccc2[C@@H]1NC(=O)c1nn(c(c1CC#N)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C27H20Cl2N4O2/c28-18-11-9-16(10-12-18)26-20(13-14-30)25(32-33(26)22-8-4-3-7-21(22)29)27(35)31-24-19-6-2-1-5-17(19)15-23(24)34/h1-12,23-24,34H,13,15H2,(H,31,35)/t23-,24+/m1/s1
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306217(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCOCC1
Show InChI InChI=1S/C22H21Cl2N5O3/c23-15-7-5-14(6-8-15)21-16(13-19(25)30)20(22(31)27-28-9-11-32-12-10-28)26-29(21)18-4-2-1-3-17(18)24/h1-8H,9-13H2,(H2,25,30)(H,27,31)
Affinity DataIC50: 1.70nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306231(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES Cc1ccncc1NC(=O)c1nn(c(c1CC(N)=O)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C24H19Cl2N5O2/c1-14-10-11-28-13-19(14)29-24(33)22-17(12-21(27)32)23(15-6-8-16(25)9-7-15)31(30-22)20-5-3-2-4-18(20)26/h2-11,13H,12H2,1H3,(H2,27,32)(H,29,33)
Affinity DataIC50: 1.70nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306216(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(2-(hydrox...)
Show SMILES ONC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H24Cl2N6O2/c24-16-10-8-15(9-11-16)22-17(14-20(26)29-33)21(23(32)28-30-12-4-1-5-13-30)27-31(22)19-7-3-2-6-18(19)25/h2-3,6-11,33H,1,4-5,12-14H2,(H2,26,29)(H,28,32)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305420(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(cyanometh...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H21Cl2N5O/c24-17-10-8-16(9-11-17)22-18(12-13-26)21(23(31)28-29-14-4-1-5-15-29)27-30(22)20-7-3-2-6-19(20)25/h2-3,6-11H,1,4-5,12,14-15H2,(H,28,31)
Affinity DataIC50: 1.80nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306214(4-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-5-(4-chl...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H23Cl2N5O2/c24-16-10-8-15(9-11-16)22-17(14-20(26)31)21(23(32)28-29-12-4-1-5-13-29)27-30(22)19-7-3-2-6-18(19)25/h2-3,6-11H,1,4-5,12-14H2,(H2,26,31)(H,28,32)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50305419(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(cyanometh...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)NC1CCCCC1
Show InChI InChI=1S/C24H22Cl2N4O/c25-17-12-10-16(11-13-17)23-19(14-15-27)22(24(31)28-18-6-2-1-3-7-18)29-30(23)21-9-5-4-8-20(21)26/h4-5,8-13,18H,1-3,6-7,14H2,(H,28,31)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306236(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-hydr...)
Show SMILES NC(=O)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(O)(CC1)c1ccccn1
Show InChI InChI=1S/C28H25Cl2N5O3/c29-19-10-8-18(9-11-19)26-20(17-24(31)36)25(33-35(26)22-6-2-1-5-21(22)30)27(37)34-15-12-28(38,13-16-34)23-7-3-4-14-32-23/h1-11,14,38H,12-13,15-17H2,(H2,31,36)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50306223(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(4-f...)
Show SMILES NC(=N)Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccccc1Cl)C(=O)N1CCC(O)(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C29H26Cl2FN5O2/c30-20-9-5-18(6-10-20)27-22(17-25(33)34)26(35-37(27)24-4-2-1-3-23(24)31)28(38)36-15-13-29(39,14-16-36)19-7-11-21(32)12-8-19/h1-12,39H,13-17H2,(H3,33,34)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
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