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TargetVirulence sensor histidine kinase PhoQ(Salmonella typhimurium (strain LT2 / SGSC1412 / AT...)
Williams College

Curated by ChEMBL
LigandPNGBDBM50453877(CHEMBL4209514)
Affinity DataKd:  3.91E+5nMAssay Description:Displacement of TNP-ATP from recombinant Salmonella typhimurium GST-tagged DHp-catalytic domain PhoQ (332 to 487 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVirulence sensor histidine kinase PhoQ(Salmonella typhimurium (strain LT2 / SGSC1412 / AT...)
Williams College

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  7.15E+5nMAssay Description:Binding affinity to recombinant Salmonella typhimurium 15N-labeled PhoQ catalytic domain (332 to 487 residues) expressed in Escherichia coli XA90 ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM36411(PIK294 | CID24905149 | 2-((4-amino-3-(3-hydroxyphe...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of California San Francisco

LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 8nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 47nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of California San Francisco

LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 53nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 72nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 130nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 130nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 170nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 170nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36411(PIK294 | CID24905149 | 2-((4-amino-3-(3-hydroxyphe...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 340nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 410nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 410nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36411(PIK294 | CID24905149 | 2-((4-amino-3-(3-hydroxyphe...)
Affinity DataIC50: 670nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50324688(N-(4-(4-tert-butylphenylamino)quinazolin-6-yl)acry...)
Affinity DataIC50: 689nMAssay Description:Inhibition of human recombinant EGFR expressed in baculovirus-infected Sf9 cells by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR/Tyrosine-protein kinase HCK(Human)
University of California San Francisco

LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 1.20E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 1.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 1.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 1.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 1.50E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 2.30E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 3.00E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4/Serine/threonine-protein kinase mTOR(Human)
University of California San Francisco

LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 3.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 3.60E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50324687(N-(4-(phenylamino)quinazolin-6-yl)acrylamide | N-(...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of Fyn expressed in Escherichia coli C43 by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetReceptor protein-tyrosine kinase/Serine/threonine-protein kinase mTOR(Human)
University of California San Francisco

LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 4.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 5.10E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36408(CID24905153 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)...)
Affinity DataIC50: 7.00E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetHistidine kinase(Caulobacter vibrioides)
Williams College

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of recombinant Caulobacter vibrioides cell cycle histidine kinase CckA deltaTM mutant DHp domain (70 to 691 residues) expressed in Escheri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit/Tyrosine-protein kinase HCK(Human)
University of California San Francisco

LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 8.90E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36411(PIK294 | CID24905149 | 2-((4-amino-3-(3-hydroxyphe...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 1.10E+4nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetHistidine kinase(Caulobacter vibrioides)
Williams College

Curated by ChEMBL
LigandPNGBDBM15364(4-chloro-6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of recombinant Caulobacter vibrioides cell cycle histidine kinase CckA deltaTM mutant DHp domain (70 to 691 residues) expressed in Escheri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 1.20E+4nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetHistidine kinase(Caulobacter vibrioides)
Williams College

Curated by ChEMBL
LigandPNGBDBM50453878(CHEMBL371380)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of recombinant Caulobacter vibrioides cell cycle histidine kinase CckA deltaTM mutant DHp domain (70 to 691 residues) expressed in Escheri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 1.30E+4nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
LigandPNGBDBM36410(CID24905148 | 1-cyclopentyl-3-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
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