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TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50434903(CHEMBL2385223)
Affinity DataKi:  0.00100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of N-arachidonoyldopamine-induced activity after 5 mins by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398494(CHEMBL2177429)
Affinity DataKi:  0.0100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of N-acetyldopamine-induced activity after 5 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398494(CHEMBL2177429)
Affinity DataKi:  0.0100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of N-acetyldopamine-induced activity after 5 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50049553(CHEMBL2177428)
Affinity DataKi:  0.0200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of N-arachidonoyl dopamine-induced activity by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50061298(CHEMBL3393837)
Affinity DataKi:  0.0200nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of NADA-induced effect at 1 uM by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50049553(CHEMBL2177428)
Affinity DataKi:  0.0200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of N-arachidonoyl dopamine-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50073160(CHEMBL3407762)
Affinity DataKi:  0.0200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of N-arachidonoyl dopamine-induced activity by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0230nMAssay Description:In vitro binding affinity towards vanilloid receptor by [3H]RTX displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50128911(CHEMBL3627723)
Affinity DataKi:  0.0300nMAssay Description:Antagonist activity at human TRPV1 heterologously expressed in CHO cells assessed as inhibition of NADA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50128922(CHEMBL3627950)
Affinity DataKi:  0.0300nMAssay Description:Antagonist activity at human TRPV1 heterologously expressed in CHO cells assessed as inhibition of NADA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM176555(US9120756, 17)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of NADA-induced intracellular calcium level preincubated with cells ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50073159(CHEMBL3407765)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of N-arachidonoyl dopamine-induced activity by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0426nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0430nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50442379(CHEMBL2442912)
Affinity DataKi:  0.0500nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of N-acetyldopamine-induced activity after 5 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247744(CHEMBL504725 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  0.0730nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275762(CHEMBL4125690)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at recombinant rat TRPV1 expressed in HEK293 cells assessed as reduction in capsaicin-induced Ca2+ flux preincubated for 3 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057514((10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]- PDBu from Protein kinase C delta C1b domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM176555(US9120756, 17)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50450981(CHEMBL4215829)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM176564(US9120756, 26)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM176564(US9120756, 26)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of NADA-induced intracellular calcium level preincubated with cells ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM176564(US9120756, 26)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50463472(CHEMBL4242293)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as reduction in NADA-induced intracellular calcium level preincubated with cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50256547(CHEMBL4104073)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin induced calcium influx pretreated for 6 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50046377(CHEMBL3314406)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50046379(CHEMBL3314407)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50046394(CHEMBL3314409)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50046396(CHEMBL3314411)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50088020(CHEMBL3427109)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM176555(US9120756, 17)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50133235(CHEMBL132720 | Docosanedioic acid ((S)-5-hydroxyme...)
Affinity DataKi:  0.110nMAssay Description:Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant C1b domain of murine Protein kinase C delta in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50052442((4-Hydroxy-3-methoxy-phenyl)-acetic acid (2R,3S,3a...)
Affinity DataKi:  0.130nMAssay Description:In vitro binding to Rat Vanilloid receptor 1 (VR1) expressing CHO cells compared to capsacinMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50333930(CHEMBL1644419 | [(2R,6R,10S,15S,17R)-13-benzyl-6-h...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099646(5,6-dihydroxy-7-hydroxymethyl-3,11,11,14-tetrameth...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain (Wild type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86434(12-Deoxyphorbol 13-phenylacetate | CAS_105100 | NS...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50133238(CHEMBL334853 | Hexadecanedioic acid ((S)-5-hydroxy...)
Affinity DataKi:  0.140nMAssay Description:Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant C1b domain of murine Protein kinase C delta in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM50099646(5,6-dihydroxy-7-hydroxymethyl-3,11,11,14-tetrameth...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C delta type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92596(Sapintoxin D)
Affinity DataKi:  0.140nM ΔG°:  -54.9kJ/molepH: 7.4 T: 18°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099646(5,6-dihydroxy-7-hydroxymethyl-3,11,11,14-tetrameth...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (F13G)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50333927(CHEMBL1644416 | [(2R,6R,10S,15S,17R)-13-benzyl-6-h...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas guanyl-releasing protein 3(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244449((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275762(CHEMBL4125690)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in CHOK1 cells assessed as reduction in capsaicin-induced Ca2+ flux after 15 mins by fluo-4-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50046299(CHEMBL3314393)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398494(CHEMBL2177429)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin-induced activity by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398511(CHEMBL2178063)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin-induced activity by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398552(CHEMBL2178059)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin-induced activity by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398553(CHEMBL2177441)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin-induced activity by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398511(CHEMBL2178063)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human TRPV1 heterologously expressed in CHO cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50398484(CHEMBL2177440)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human TRPV1 heterologously expressed in CHO cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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