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TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055014(7-(3,4-Dichloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter in rat striatal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of [3H]paroxetine (0.2 nM) binding to 5-HT transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50453639(CHEMBL2112889)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of [3H]paroxetine binding to 5-hydroxytryptamine (5-HT) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035734([3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 0.370nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50006784(CHEMBL82946 | RTI-121 | 3-(4-Iodo-phenyl)-8-methyl...)
Affinity DataIC50: 0.430nMAssay Description:Compound was evaluated for the inhibition of [3H]WIN-35428l binding to dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50006784(CHEMBL82946 | RTI-121 | 3-(4-Iodo-phenyl)-8-methyl...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine (DA) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035725(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Affinity DataIC50: 0.430nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50052158((2S,5R)-3-(4-Chloro-phenyl)-8-methyl-2-(3-methyl-i...)
Affinity DataIC50: 0.590nMAssay Description:Binding affinity against Dopamine transporter using [3H]WIN-35 428 in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50053650(3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035747(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Affinity DataIC50: 0.610nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50041282((3S,8R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine (DA) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 0.620nMAssay Description:In vitro inhibitory activity against radioligand [3H]-WN 35,428 binding to dopamine transporter (DAT) in rat striatal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50453639(CHEMBL2112889)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine (DA) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50061203((R)-3-(4-Ethyl-3-iodo-phenyl)-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50: 0.690nMAssay Description:In vitro inhibitory activity against radioligand [3H]paroxetine binding to serotonin transporter (5-HTT) in rat midbrain tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50052173((2S,5R)-3-(4-Iodo-phenyl)-8-methyl-2-(3-methyl-iso...)
Affinity DataIC50: 0.730nMAssay Description:Binding affinity against Dopamine transporter using [3H]WIN-35 428 in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035758([3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 0.75nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50453398(CHEMBL2373961)
Affinity DataIC50: 0.790nMAssay Description:Concentration required to inhibit 50% of radioligand binding ([3H]WIN-35428) to the dopamine (DA) transporter in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035730(3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50: 0.790nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035764(3-(4-Chloro-3-methyl-phenyl)-8-methyl-8-aza-bicycl...)
Affinity DataIC50: 0.810nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035765(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 0.850nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50052156((2S,5R)-8-Methyl-2-(3-methyl-isoxazol-5-yl)-3-p-to...)
Affinity DataIC50: 0.930nMAssay Description:Binding affinity against Dopamine transporter using [3H]WIN-35 428 in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035743(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 0.960nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055013(9-(3-Chloro-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM22165(Vanoxerine | CHEMBL542933 | GBR-12909 | CHEMBL5438...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [125I]RTI-55 cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]mazindol binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50008039(CHEMBL284394 | 3-Benzoyloxy-8-methyl-8-aza-bicyclo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]-dopamine uptake at dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005576((3S,8R)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3...)
Affinity DataIC50: 1nMAssay Description:Potency for the inhibition of [3H]WIN-35428 binding to the dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards Dopamine transporter by displacement of [3H]WIN-35428 radioligand from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.10nMAssay Description:Concentration required to inhibit 50% of radioligand binding ([3H]WIN-35428) to the dopamine (DA) transporter in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50453638(CHEMBL2112877)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine (DA) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine (DA) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035731(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity against Dopamine transporter using [3H]WIN-35 428 in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibitory activity against radioligand [3H]-WN 35,428 binding to dopamine transporter (DAT) in rat striatal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.20nMAssay Description:Affinity against cocaine binding site of dopamine transporter in rat striatum using [3H]2b as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [3H]WIN-35248 binding to the dopamine transporter in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for the inhibition of [3H]WIN-35428l binding to dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50053635(3-(4-Ethynyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50053641(3-[((Z)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50053647(8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50053637(3-(4-Ethynyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50: 1.26nMAssay Description:Inhibition of [3H]WIN-35428 binding to Dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50055013(9-(3-Chloro-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter in rat striatal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005576((3S,8R)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3...)
Affinity DataIC50: 1.30nMAssay Description:Affinity against cocaine binding site of dopamine transporter in rat striatum using [3H]2b as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50006774(CHEMBL311347 | (2S,3S)-methyl 3-(4-iodophenyl)-8-m...)
Affinity DataIC50: 1.30nMAssay Description:Compound was evaluated for the inhibition of [3H]WIN-35428l binding to dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005576((3S,8R)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3...)
Affinity DataIC50: 1.30nMAssay Description:Concentration required to inhibit 50% of radioligand binding ([3H]WIN-35428) to the dopamine (DA) transporter in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005576((3S,8R)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine (DA) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity towards dopamine transporter was determined using DA[3H]WIN-35428 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
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