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TargetCTP synthase 2(Rat)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50: 13nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 2(Human)
Dalhousie University

LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataKd:  17nMpH: 7.4 T: 2°CAssay Description:Recombinant OSBP, ORP4L, or ORP4S (8 pmol) was incubated in 75 μl of binding buffer (10 mM HEPES (pH 7.4), 150 mM KCl, 2% (w/v) polyvinyl alcohol)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetCTP synthase 2(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50: 18nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 2(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50: 19nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 2 [1-181,275-916](Human)
Dalhousie University

LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataKd:  23nMpH: 7.4 T: 2°CAssay Description:Recombinant OSBP, ORP4L, or ORP4S (8 pmol) was incubated in 75 μl of binding buffer (10 mM HEPES (pH 7.4), 150 mM KCl, 2% (w/v) polyvinyl alcohol)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetCTP synthase 2(Rat)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50: 23nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50: 26nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 2(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50: 27nMAssay Description:Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50: 32nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 2(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 2(Rat)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50: 35nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50: 42nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50: 53nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 2 [1-181,275-916](Human)
Dalhousie University

LigandPNGBDBM20192((1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-...)
Affinity DataKd:  60nMpH: 7.4 T: 2°CAssay Description:Recombinant OSBP, ORP4L, or ORP4S (8 pmol) was incubated in 75 μl of binding buffer (10 mM HEPES (pH 7.4), 150 mM KCl, 2% (w/v) polyvinyl alcohol)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetOxysterol-binding protein 2(Human)
Dalhousie University

LigandPNGBDBM20192((1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-...)
Affinity DataKd:  68nMpH: 7.4 T: 2°CAssay Description:Recombinant OSBP, ORP4L, or ORP4S (8 pmol) was incubated in 75 μl of binding buffer (10 mM HEPES (pH 7.4), 150 mM KCl, 2% (w/v) polyvinyl alcohol)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetCTP synthase 2(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50: 113nMAssay Description:Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609644(CHEMBL5288271)
Affinity DataIC50: 180nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609662(CHEMBL5275093)
Affinity DataIC50: 210nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 2(Rat)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50: 235nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 2(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50: 242nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609647(CHEMBL5291055)
Affinity DataIC50: 250nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609664(CHEMBL5270156)
Affinity DataIC50: 420nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609665(CHEMBL5288933)
Affinity DataIC50: 430nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50: 440nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609663(CHEMBL5288354)
Affinity DataIC50: 440nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609668(CHEMBL5287919)
Affinity DataIC50: 440nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609652(CHEMBL5284514)
Affinity DataIC50: 570nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50: 580nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM21625(2-phenyl-5-(1H-pyrazol-5-yl)thiazole | 2-phenyl-5-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324491(N-Benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carbox...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCTP synthase 2(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50: 710nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609661(CHEMBL5278356)
Affinity DataIC50: 950nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324482(N-(1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-30-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCTP synthase 2(Mouse)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324480(N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324485(N-(1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM21624(4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]a...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324490(5-(3-Aminophenyl)-N-benzhydrylthiophene-2-carboxam...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324484(N-(1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609643(CHEMBL5266038)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324486(N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxy...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50300128(4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]P...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609666(CHEMBL5280120)
Affinity DataIC50: 4.47E+3nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609660(CHEMBL5270880)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324483(N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybi...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50324487(N-(1-Amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxy...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609667(CHEMBL5279706)
Affinity DataIC50: 7.18E+3nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCTP synthase 1(Human)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609675(CHEMBL5288448)
Affinity DataIC50: 7.82E+3nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
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