Compile Data Set for Download or QSAR
Found 790 with Last Name = 'brough' and Initial = 's'
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444496(CHEMBL3092650)
Affinity DataKi:  0.148nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from rat histamine H3 receptor expressed in HEK293 cells after 45 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50002087(4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thi...)
Affinity DataKi:  0.158nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444491(CHEMBL3092823)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444496(CHEMBL3092650)
Affinity DataKi:  0.363nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444500(CHEMBL3092834)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444507(CHEMBL3092826)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444505(CHEMBL3092828)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50397494(CHEMBL2171047)
Affinity DataKi:  0.631nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444509(CHEMBL3092840)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50247054(6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  0.676nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from rat histamine H3 receptor expressed in HEK293 cells after 45 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444495(CHEMBL3092651)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444489(CHEMBL3092825)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50346209(5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  0.832nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444506(CHEMBL3092827)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444494(CHEMBL3092820)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50346209(5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from rat histamine H3 receptor expressed in HEK293 cells after 45 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444493(CHEMBL3092821)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444510(CHEMBL3092839)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50218750(CHEMBL299498)
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444497(CHEMBL3092649)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444499(CHEMBL3092835)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444490(CHEMBL3092824)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444492(CHEMBL3092822)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50397482(CHEMBL2171013)
Affinity DataKi:  2.51nMAssay Description:Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50247054(6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50397483(CHEMBL2171014)
Affinity DataKi:  3.16nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444498(CHEMBL3092648)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50417376(CHEMBL1278116)
Affinity DataKi:  3.98nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444511(CHEMBL3092838)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444501(CHEMBL3092832)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50218751(CHEMBL300835)
Affinity DataKi:  4nMAssay Description:Binding affinity against 5-hydroxytryptamine 2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444502(CHEMBL3092831)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataKi:  4.68nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444504(CHEMBL3092829)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50397501(CHEMBL2171039)
Affinity DataKi:  5.01nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50397516(CHEMBL2171021)
Affinity DataKi:  5.01nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.37nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.62nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  6.31nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM50003359(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Affinity DataKi:  6.31nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50397498(CHEMBL2171043)
Affinity DataKi:  6.31nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50394155(CHEMBL2158814)
Affinity DataKi:  6.31nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444503(CHEMBL3092830)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50397486(CHEMBL2171048)
Affinity DataKi:  7.94nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50397489(CHEMBL2171035)
Affinity DataKi:  7.94nMAssay Description:Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50397498(CHEMBL2171043)
Affinity DataKi:  7.94nMAssay Description:Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50397518(CHEMBL2171019)
Affinity DataKi:  7.94nMAssay Description:Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  8.71nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50444508(CHEMBL3091477)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50417355(CHEMBL1278114)
Affinity DataKi:  10nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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