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TargetRunt-related transcription factor 1(Human)
University of Virginia At Charlottesville

LigandPNGBDBM31190(thiazol-2-amine, 1)
Affinity DatapH: 7.5 T: 2°CAssay Description:For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetRunt-related transcription factor 1(Human)
University of Virginia At Charlottesville

LigandPNGBDBM31191(thiazol-2-amine, 2)
Affinity DatapH: 7.5 T: 2°CAssay Description:For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetRunt-related transcription factor 1(Human)
University of Virginia At Charlottesville

LigandPNGBDBM31192(thiazol-2-amine, 3)
Affinity DatapH: 7.5 T: 2°CAssay Description:For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetRunt-related transcription factor 1(Human)
University of Virginia At Charlottesville

LigandPNGBDBM31193(thiazol-2-amine, 4)
Affinity DatapH: 7.5 T: 2°CAssay Description:For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetRunt-related transcription factor 1(Human)
University of Virginia At Charlottesville

LigandPNGBDBM31194(thiazol-2-amine, 12)
Affinity DatapH: 7.5 T: 2°CAssay Description:For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetRunt-related transcription factor 1(Human)
University of Virginia At Charlottesville

LigandPNGBDBM31195(thiazol-2-amine, 15)
Affinity DatapH: 7.5 T: 2°CAssay Description:For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  2.40E+3nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM221048(US9303017, Varenicline | US9284322, varenicline)
Affinity DataEC50:  950nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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PDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataEC50:  24nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM50428085(CHEMBL2323566 | US9303017, (S)-15, YL-1-127)
Affinity DataEC50:  310nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM50428079(CHEMBL2323569 | US9303017, 25, YL-1-199)
Affinity DataEC50:  160nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)
Affinity DataEC50:  63nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
Georgetown University

US Patent
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  2.30E+4nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
Georgetown University

US Patent
LigandPNGBDBM221048(US9303017, Varenicline | US9284322, varenicline)
Affinity DataEC50:  2.20E+4nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
Georgetown University

US Patent
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataEC50:  2.40E+4nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
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TargetAndrogen receptor [646-919](Human)
Karlsruhe Institute of Technology

LigandPNGBDBM227645(MAQRGGARRPRGDRERLGSR | Bag-1L (1-20))
Affinity DataKd:  2.00E+3nMpH: 6.5Assay Description:For the fluorescence polarization experiments, 5 nM fluorescently labeled Bag-1L (Bag-1L(1-20), fluorescein isothiocyanate (FITC)-MAQRGGARRPRGDRERLGS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details Article
PubMed
TargetAndrogen receptor [646-919](Human)
Karlsruhe Institute of Technology

LigandPNGBDBM227646(RGAAAGARRPRMKKKTRRRS | Bag-1L (61-80))
Affinity DataKd:  3.30E+3nMpH: 6.5Assay Description:For the fluorescence polarization experiments, 5 nM fluorescently labeled Bag-1L (Bag-1L(1-20), fluorescein isothiocyanate (FITC)-MAQRGGARRPRGDRERLGS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details Article
PubMed
TargetAndrogen receptor [646-919](Human)
Karlsruhe Institute of Technology

LigandPNGBDBM227647(HDSKGQTKLLQLLTTKSDQM | SCR-2 peptide)
Affinity DataKd:  2.80E+3nMpH: 6.5Assay Description:For the fluorescence polarization experiments, 5 nM fluorescently labeled Bag-1L (Bag-1L(1-20), fluorescein isothiocyanate (FITC)-MAQRGGARRPRGDRERLGS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2017
Entry Details Article
PubMed
TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456559(US10736883, Example 2.0)
Affinity DataEC50:  1.30E+4nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456560(US10736883, Example 3.0)
Affinity DataEC50:  0.310nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456561(US10736883, Example 4.0)
Affinity DataEC50:  0.770nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456568(US10736883, Example 5.0)
Affinity DataEC50:  0.950nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456569(US10736883, Example 6.0)
Affinity DataEC50:  0.980nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456570(US10736883, Example 7.0)
Affinity DataEC50:  3nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456571(US10736883, Example 8.0)
Affinity DataEC50:  28nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456572(US10736883, Example 9.0)
Affinity DataEC50:  0.0910nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456573(US10736883, Example 10.0)
Affinity DataEC50:  0.110nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456574(US10736883, Example 11.0)
Affinity DataEC50:  0.140nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456575(US10736883, Example 12.0)
Affinity DataEC50:  0.150nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456576(US10736883, Example 13.0)
Affinity DataEC50:  0.190nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456577(US10736883, Example 14.0)
Affinity DataEC50:  0.200nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456578(US10736883, Example 15.0)
Affinity DataEC50:  0.210nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456579(US10736883, Example 16.0)
Affinity DataEC50:  0.220nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456580(US10736883, Example 17.0)
Affinity DataEC50:  0.260nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456581(US10736883, Example 18.0)
Affinity DataEC50:  0.280nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456582(US10736883, Example 19.0)
Affinity DataEC50:  0.290nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456583(US10736883, Example 20.0)
Affinity DataEC50:  0.300nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456584(US10736883, Example 21.0)
Affinity DataEC50:  0.310nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456585(US10736883, Example 22.0)
Affinity DataEC50:  0.310nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456586(US10736883, Example 23.0)
Affinity DataEC50:  0.360nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456587(US10736883, Example 24.0)
Affinity DataEC50:  0.360nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456588(US10736883, Example 25.0)
Affinity DataEC50:  0.370nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456589(US10736883, Example 26.0)
Affinity DataEC50:  0.420nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456590(US10736883, Example 27.0)
Affinity DataEC50:  0.460nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456591(US10736883, Example 28.0)
Affinity DataEC50:  0.480nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456592(US10736883, Example 29.0)
Affinity DataEC50:  0.820nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456593(US10736883, Example 30.0)
Affinity DataEC50:  1.20nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456594(US10736883, Example 31.0)
Affinity DataEC50:  1.90nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456595(US10736883, Example 32.0)
Affinity DataEC50:  2.30nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM456596(US10736883, Example 33.0)
Affinity DataEC50:  2.40nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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