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TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19368(1-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  56nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19369(1-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19370(3-tert-butyl-1-(4-{2,4-diamino-6-[(benzyloxy)methy...)
Affinity DataEC50:  7nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19371(3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  88nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19372(1-benzyl-3-(4-{2,4-diamino-6-[(benzyloxy)methyl]py...)
Affinity DataEC50:  34nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19373(3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  10nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19374(3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  7nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19352(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-...)
Affinity DatapH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475953(CHEMBL384564)
Affinity DataEC50:  145nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475954(CHEMBL216256)
Affinity DataEC50:  169nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475954(CHEMBL216256)
Affinity DataEC50:  467nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50062397(N''-cyano-N-(1,1-dimethylpropyl)-N'-pyridin-3-ylgu...)
Affinity DataEC50:  52nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50475955(CHEMBL386853)
Affinity DataEC50:  2.95E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475956(CHEMBL426874)
Affinity DataEC50:  436nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM86249(ZD-6169 | ZD 6169)
Affinity DataEC50:  1.35E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475957(CHEMBL214616)
Affinity DataEC50: <1.00E+4nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475958(CHEMBL424726)
Affinity DataEC50:  72nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475959(CHEMBL214566)
Affinity DataEC50:  91.2nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475960(CHEMBL215026)
Affinity DataEC50:  1.14E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475961(CHEMBL214841)
Affinity DataEC50:  29nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475962(CHEMBL215681)
Affinity DataEC50:  891nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475954(CHEMBL216256)
Affinity DataEC50:  2.29E+3nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475963(CHEMBL2062142 | WAY-133537)
Affinity DataEC50:  676nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475954(CHEMBL216256)
Affinity DataEC50:  55nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475964(CHEMBL384537)
Affinity DataEC50:  1.02E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475965(CHEMBL451561)
Affinity DataEC50: <1.00E+4nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475966(CHEMBL384576)
Affinity DataEC50:  28nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475967(CHEMBL217033)
Affinity DataEC50:  219nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475961(CHEMBL214841)
Affinity DataEC50:  512nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475968(CHEMBL214892)
Affinity DataEC50:  1.31E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475959(CHEMBL214566)
Affinity DataEC50:  3.38E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475969(CHEMBL386228)
Affinity DataEC50:  102nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475970(CHEMBL426334)
Affinity DataEC50:  51.3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475971(CHEMBL386363)
Affinity DataEC50:  9.80nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475972(CHEMBL216546)
Affinity DataEC50:  22.9nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM86249(ZD-6169 | ZD 6169)
Affinity DataEC50:  295nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475970(CHEMBL426334)
Affinity DataEC50:  51nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475973(CHEMBL265269)
Affinity DataEC50:  14nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475974(CHEMBL384173)
Affinity DataEC50:  1.58E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475975(CHEMBL386843)
Affinity DataEC50:  851nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475976(CHEMBL383900)
Affinity DataEC50:  436nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475974(CHEMBL384173)
Affinity DataEC50:  1.59E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475977(CHEMBL386582)
Affinity DataEC50:  26.9nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475972(CHEMBL216546)
Affinity DataEC50:  23nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475978(CHEMBL386136)
Affinity DataEC50:  309nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475979(CHEMBL386585)
Affinity DataEC50:  3.63E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475980(CHEMBL214928)
Affinity DataEC50:  5.01E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475981(CHEMBL413532)
Affinity DataEC50:  1.80nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475982(CHEMBL215375)
Affinity DataEC50:  169nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475962(CHEMBL215681)
Affinity DataEC50:  891nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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