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TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35536(symmetric dicoumarol analogue, 12)
Affinity DataIC50: 0.180nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35534(symmetric dicoumarol analogue, 10)
Affinity DataIC50: 0.410nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35537(symmetric dicoumarol analogue, 13)
Affinity DataIC50: 0.420nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35544(4-hydroxy-2H-chromen-2-one core, 20)
Affinity DataIC50: 2.20nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35541(4-hydroxy-2H-chromen-2-one core, 17)
Affinity DataIC50: 2.5nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35525(dicoumarol | 3,3''''-methylenebis(4-hydroxycoumari...)
Affinity DataIC50: 2.60nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35527(symmetric dicoumarol analogue, 3)
Affinity DataIC50: 2.80nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35531(symmetric dicoumarol analogue, 7)
Affinity DataIC50: 3.80nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35530(symmetric dicoumarol analogue, 6)
Affinity DataIC50: 4.5nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35533(symmetric dicoumarol analogue, 9)
Affinity DataIC50: 4.90nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM50055714(CHEMBL312727 | CHEMBL238291 | 3-(4,7-dihydroxy-2-o...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant NQO1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35525(dicoumarol | 3,3''''-methylenebis(4-hydroxycoumari...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant NQO1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35529(symmetric dicoumarol analogue, 5)
Affinity DataIC50: 6nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35547(4-hydroxy-2H-chromen-2-one core, 23)
Affinity DataIC50: 6nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50317140(NSC-660841 | 5-(2-(diethylamino)ethylamino)-7-hydr...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35543(4-hydroxy-2H-chromen-2-one core, 19)
Affinity DataIC50: 6.30nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35546(4-hydroxy-2H-chromen-2-one core, 22)
Affinity DataIC50: 6.30nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35540(4-hydroxy-2H-chromen-2-one core, 16)
Affinity DataIC50: 7.70nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35532(symmetric dicoumarol analogue, 8)
Affinity DataIC50: 9nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50008356(CHEMBL124254 | 5-(2-Diethylamino-ethylamino)-8-met...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35552(4-hydroxy-2H-chromen-2-one core, 29)
Affinity DataIC50: 9.90nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515994(CHEMBL4514167)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35528(symmetric dicoumarol analogue, 4)
Affinity DataIC50: 11nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515978(CHEMBL1967497)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35526(symmetric dicoumarol analogue, 2)
Affinity DataIC50: 14nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35550(4-hydroxy-2H-chromen-2-one core, 26)
Affinity DataIC50: 14nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50354527(CHEMBL1836819)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35548(4-hydroxy-2H-chromen-2-one core, 24)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515995(CHEMBL4435240)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50150962(CHEMBL3770366)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50150963(CHEMBL3770674)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50008344(CHEMBL125082 | NSC-637992 | 5-(2-Diethylamino-ethy...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50317138(5-(2-(diethylamino)ethylamino)-7,10-dimethoxy-6H-i...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515985(TCMDC-142036 | CHEMBL1237241)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetThymidine phosphorylase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(CHEMBL122679 | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,...)
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine phosphorylase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(CHEMBL122679 | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,...)
Affinity DataIC50: 19nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine phosphorylase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(CHEMBL122679 | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine phosphorylase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetThymidine phosphorylase(Escherichia coli (strain K12))
University of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against thymidine phosphorylase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine phosphorylase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 23nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35549(4-hydroxy-2H-chromen-2-one core, 25)
Affinity DataIC50: 24nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50150962(CHEMBL3770366)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the prsence of BSAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50151002(CHEMBL3770215)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50150963(CHEMBL3770674)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the prsence of BSAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35551(4-hydroxy-2H-chromen-2-one core, 28)
Affinity DataIC50: 31nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50317139(NSC-660840 | 5-(2-Diethylamino-ethylamino)-7-hydro...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM35545(4-hydroxy-2H-chromen-2-one core, 21)
Affinity DataIC50: 35nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50388602(FURAMIDINE)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human NQO2 assessed as change in rate of decolouration of DCPIP measured over 1 min by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine phosphorylase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
The University of Manchester and Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50388602(FURAMIDINE)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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