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TargetHeat shock protein 90, putative(Plasmodium falciparum (isolate 3D7))
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50406805(CHEMBL585793 | GNF-Pf-4574)
Affinity DataKd:  27nMAssay Description:Binding affinity to Plasmodium falciparum HSP90 nucleotide binding domain by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein 90, putative(Plasmodium falciparum (isolate 3D7))
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50406806(CHEMBL598685 | GNF-Pf-4035 | SJ000111021)
Affinity DataKd:  7nMAssay Description:Binding affinity to Plasmodium falciparum HSP90 nucleotide binding domain by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgrammed cell death protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50546617(CHEMBL4793446)
Affinity DataKd:  1.66E+6nMAssay Description:Binding affinity to PD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50546617(CHEMBL4793446)
Affinity DataKd:  5.67E+3nMAssay Description:Binding affinity to PDL1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625379(CHEMBL5408017)
Affinity DataKd:  270nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625380(CHEMBL5413905)
Affinity DataKd:  340nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625381(CHEMBL5427799)
Affinity DataKd:  420nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625382(CHEMBL5397185)
Affinity DataKd:  330nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625383(CHEMBL5440896)
Affinity DataKd:  670nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625384(CHEMBL5436468)
Affinity DataKd:  230nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625385(CHEMBL5436645)
Affinity DataKd:  270nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625386(CHEMBL5418854)
Affinity DataKd:  230nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625387(CHEMBL5436714)
Affinity DataKd:  870nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625388(CHEMBL5432791)
Affinity DataKd:  570nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625389(CHEMBL5400791)
Affinity DataKd:  490nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625390(CHEMBL5428687)
Affinity DataKd:  150nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625391(CHEMBL5396741)
Affinity DataKd:  330nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625392(CHEMBL5418550)
Affinity DataKd:  270nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625393(CHEMBL5419800)
Affinity DataKd:  220nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625394(CHEMBL5406416)
Affinity DataKd:  300nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625395(CHEMBL5421648)
Affinity DataKd:  510nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625396(CHEMBL5426728)
Affinity DataKd:  67nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625397(CHEMBL5406257)
Affinity DataKd:  77nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625398(CHEMBL5441057)
Affinity DataKd:  65nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50511422(CHEMBL4446338)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50625399(CHEMBL5423303)
Affinity DataKd:  34nMAssay Description:Binding affinity to full length wild type human PI5P4Kgamma assessed as dissociation constant by KINOMEscan KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
LigandPNGBDBM27633(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27634(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311010(N-(4-{2-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311001(2-methoxy-4-(2-(4-morpholinophenylamino)pyrimidin-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataIC50: 3.70nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in cultured hippocampal neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27628(5-bromo-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311011(N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)ph...)
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27627(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27637(N-{3-[(1S)-1-[(5-bromopyridin-3-yl)amino]ethyl]phe...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311002(N-(4-(2-(3-(pyrrolidin-1-ylmethyl)phenylamino)pyri...)
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311012(N-(4-(2-(4-(4-hydroxypiperidin-1-yl)phenylamino)py...)
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311004(N-(4-(2-(3-(morpholinomethyl)phenylamino)pyrimidin...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311022(N-(cyanomethyl)-4-(5-methyl-2-(4-morpholinophenyla...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27631(3-chloro-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27632(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311006(N-(4-(2-(4-(morpholinomethyl)phenylamino)pyrimidin...)
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311019(N-(cyanomethyl)-2-methoxy-4-(2-(4-morpholinophenyl...)
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged JAK3 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27630(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311016(2-cyano-N-(4-(2-(4-morpholinophenylamino)pyrimidin...)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27639(N-{3-[(1S)-1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazi...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311003(N-(4-(2-(4-(piperidin-1-ylmethyl)phenylamino)pyrim...)
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged JAK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cytopia Research

Curated by ChEMBL
LigandPNGBDBM50311005(N-(4-(2-(3-((4-hydroxypiperidin-1-yl)methyl)phenyl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-tagged JAK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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