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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50422394(CHEMBL3558149)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16047(EVNXXAEF | N-{(2R,4S,5S)-5-[(L-alpha-glutamyl-L-va...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus-infected insect cells using Rh-EVNLDAEFK-quencher as substrate mea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Horse)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
Wuhan University of Technology

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.90nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of 5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a colored product. Shim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Horse)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 13nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50252033(CHEMBL4078023)
Affinity DataIC50: 20nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50252035(CHEMBL4064361)
Affinity DataIC50: 20nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Pacific electric ray)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Torpedo californica AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50457026(CHEMBL4207023)
Affinity DataIC50: 23nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 23nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of 5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a colored product. Shim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50161803(CHEMBL3785375)
Affinity DataIC50: 37nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 38nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA topoisomerase 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50363804(CHEMBL1946917)
Affinity DataIC50: 39nMAssay Description:Inhibition of DNA topoisomerase 1 (unknown origin) at 50 uM measured by agar gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50252089(CHEMBL4083642)
Affinity DataIC50: 40nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Mouse)
Nahda University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human His6-tagged MEK1 as substrate preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021461(CHEMBL3289927)
Affinity DataIC50: 42nMAssay Description:Inhibition of AChE (unknown origin) after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM203833(2-(2-Bromo-3,4,5-trimethoxy-benzylidene)-4-methyl-...)
Affinity DataIC50: 45nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of 5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a colored product. Shim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM10949(CHEMBL75121 | 3-(4-{[benzyl(methyl)amino]methyl}ph...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Wuhan University of Technology

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 47nMpH: 7.4 T: 2°CAssay Description:A fluorimetric method reported by Matsumoto et al.[T. Matsumoto, O. Suzuki, T. Furuta, M. Asai, Y. Kurokawa, Y. Nimura, Y. Katsumata, I. Takahashi. C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50457028(CHEMBL4218303)
Affinity DataIC50: 49nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50614390(CHEMBL5271106)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant 6His-tagged EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) autophosphorylation expressed in baculovirus in...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant 6His-tagged EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) autophosphorylation expressed in baculovirus in...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021471(CHEMBL3289937)
Affinity DataIC50: 57nMAssay Description:Inhibition of AChE (unknown origin) after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 57nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 59nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of 5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a colored product. Shim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50252090(CHEMBL4063890)
Affinity DataIC50: 60nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 60nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50457015(CHEMBL4203173)
Affinity DataIC50: 60nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Mouse)
Nahda University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 60nMAssay Description:Inhibition of His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells after 10...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 62nMAssay Description:Inhibition of AChE (unknown origin) after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50363797(CHEMBL1947110)
Affinity DataIC50: 67nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50457024(CHEMBL4207926)
Affinity DataIC50: 69nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 70nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) expressed in baculovirus infected Sf9 insect ce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50614382(CHEMBL5279636)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant 6His-tagged EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) autophosphorylation expressed in baculovirus in...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Horse)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50464028(CHEMBL4241164)
Affinity DataIC50: 73nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50457014(CHEMBL4203040)
Affinity DataIC50: 80nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 80nMAssay Description:Inhibition of His6-tagged EGFR (unknown origin) cytoplasmic domain expressed in baculovirus infected Sf9 insect cells after 10 mins followed by addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Horse)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50422387(CHEMBL4159171)
Affinity DataIC50: 88nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50457023(CHEMBL4207397)
Affinity DataIC50: 100nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Mouse)
Nahda University

Curated by ChEMBL
LigandPNGBDBM50457924(CHEMBL4208224)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Horse)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50422386(CHEMBL4169820)
Affinity DataIC50: 110nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Horse)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50464019(CHEMBL4245106)
Affinity DataIC50: 110nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM203832((2E)-2-[(2-chloro-3,4-dimethoxyphenyl)methylidene]...)
Affinity DataIC50: 120nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of 5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a colored product. Shim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Wuhan University of Technology

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 120nMpH: 7.4 T: 2°CAssay Description:A fluorimetric method reported by Matsumoto et al.[T. Matsumoto, O. Suzuki, T. Furuta, M. Asai, Y. Kurokawa, Y. Nimura, Y. Katsumata, I. Takahashi. C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Horse)
Wuhan University of Technology

Curated by ChEMBL
LigandPNGBDBM50464031(CHEMBL4248896)
Affinity DataIC50: 130nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50457025(CHEMBL4210751)
Affinity DataIC50: 140nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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