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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM105075(CHEMBL2152708 | US8569281, 59)
Affinity DataKi:  2.40nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50426403(CHEMBL2326726)
Affinity DataKi:  9nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50240502(CHEMBL4104732)
Affinity DataKi:  54nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091288(CHEMBL3582227)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091302(CHEMBL3582223)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091309(CHEMBL3582216)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091287(CHEMBL3582228)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091300(CHEMBL3582225)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091293(CHEMBL3582201)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091289(CHEMBL3582226)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50035709(CHEMBL3359895)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091301(CHEMBL3582224)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091320(CHEMBL3582207)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091319(CHEMBL3582208)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091294(CHEMBL3582200)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50249413(5-amino-4-(bicyclo[2.2.1]heptan-2-ylamino)-6-morph...)
Affinity DataIC50:  2nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091292(CHEMBL3582202)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091285(CHEMBL3582230)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091311(CHEMBL3582215)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091315(CHEMBL3582212)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091284(CHEMBL3582231)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM105100(US8569281, 110)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091291(CHEMBL3582203)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091307(CHEMBL3582218)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091322(CHEMBL3582205)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091318(CHEMBL3582209)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091283(CHEMBL3582232)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091314(CHEMBL3582213)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50090104(CHEMBL3581543 | US9216988, 97)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50249446(5-amino-4-(isobutylamino)-6-(piperazin-1-yl)pyrimi...)
Affinity DataIC50:  6nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50090092(CHEMBL3581539 | US9216988, 85)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50249448(4-(4-acetylpiperazin-1-yl)-5-amino-6-(isobutylamin...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091286(CHEMBL3582229)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091290(CHEMBL3582204)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091321(CHEMBL3582206)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50396160(CHEMBL2171735)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50090086(CHEMBL3581533 | US9216988, 92)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM482159(BDBM50401284 | GSK2578215A)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091322(CHEMBL3582205)
Affinity DataIC50:  11nMAssay Description:Inhibition of human acetylcholine esterase by horseradish peroxidase-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091275(CHEMBL3582191)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091317(CHEMBL3582210)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420701(CHEMBL2087461)
Affinity DataIC50:  12nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025224(CHEMBL3330649)
Affinity DataIC50:  12nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50420692(CHEMBL2087076)
Affinity DataIC50:  13nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50249380(5-amino-4-(cyclopentylamino)-6-morpholinopyrimidin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50249449(5-Amino-4-(1,1-dioxo-tetrahydro-1lambda*6*-thiophe...)
Affinity DataIC50:  14nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091313(CHEMBL3582214)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091316(CHEMBL3582211)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091276(CHEMBL3582190)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
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