Compile Data Set for Download or QSAR
Report error Found 173 with Last Name = 'busch' and Initial = 'd'
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20773(2-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Affinity DataEC50:  300nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20751(CHEMBL199532 | 9-[3-(tert-butylamino)propyl]-8-[(2...)
Affinity DataEC50:  140nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20741(9-butyl-8-[(2-chloro-5-methoxyphenyl)methyl]-9H-pu...)
Affinity DataEC50:  2.00E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20783(CHEMBL212133 | diethyl {2-[6-amino-8-({7-bromopyri...)
Affinity DataEC50:  28nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20813(6-chloro-9-{[3,5-dimethyl-4-(methylsulfanyl)pyridi...)
Affinity DataEC50:  27nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM15359(17AAG | Tanespimycin | GLD-36 | (4E,6Z,8S,9S,10E,1...)
Affinity DataEC50:  7nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20795(2-amino-9-[(2-chloro-3,4,5-trimethoxyphenyl)methyl...)
Affinity DataEC50:  700nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20762(9-butyl-8-[(6,7-dichloro-1,3-benzothiazol-2-yl)sul...)
Affinity DataEC50:  2.50E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20790(9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]-6-chlor...)
Affinity DataEC50:  70nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20801(2-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-3,5-dim...)
Affinity DataEC50:  1.00E+5nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20786(3-[6-amino-8-({7-chloropyrido[3,4-d][1,3]thiazol-2...)
Affinity DataEC50:  170nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20760(9-butyl-8-[(7-fluoro-1,3-benzothiazol-2-yl)sulfany...)
Affinity DataEC50:  200nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20761(9-butyl-8-[(7-methyl-1,3-benzothiazol-2-yl)sulfany...)
Affinity DataEC50:  300nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20789(6-chloro-9-[(2-chloro-3,4,5-trimethoxyphenyl)methy...)
Affinity DataEC50:  50nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20753(9-{2-[(2,2-dimethylpropyl)amino]ethyl}-8-[(2-iodo-...)
Affinity DataEC50:  90nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM15381(8-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluo...)
Affinity DataEC50:  1.70E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20784(9-butyl-8-({7-chloropyrido[3,4-d][1,3]thiazol-2-yl...)
Affinity DataEC50:  280nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20779(8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9-[2-...)
Affinity DataEC50:  110nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20792(6-bromo-9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20759(8-[(7-bromo-1,3-benzothiazol-2-yl)sulfanyl]-9-buty...)
Affinity DataEC50:  330nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataEC50:  30nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20758(CHEMBL213262 | 9-butyl-8-[(7-chloro-1,3-benzothiaz...)
Affinity DataEC50:  180nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20754(8-(1,3-benzothiazol-2-ylsulfanyl)-9-butyl-9H-purin...)
Affinity DataEC50:  5.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20781(9-[3-(tert-butylamino)propyl]-8-[(7-chloro-1,3-ben...)
Affinity DataEC50:  150nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20766(8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9-pro...)
Affinity DataEC50:  250nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20799(CHEMBL468781 | 6-chloro-9-[(5-methoxy-4,6-dimethyl...)
Affinity DataEC50:  20nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20814(6-chloro-9-[(4-methanesulfinyl-3,5-dimethylpyridin...)
Affinity DataEC50: >1.00E+4nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20802(6-chloro-9-[(4-ethoxy-3,5-dimethylpyridin-2-yl)met...)
Affinity DataEC50:  1.50E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20785(CHEMBL212850 | diethyl {2-[6-amino-8-({7-chloropyr...)
Affinity DataEC50:  30nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20770(4-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Affinity DataEC50:  130nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM15378(PU7 | 9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-a...)
Affinity DataEC50:  1.20E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20742(8-[(2-bromo-5-methoxyphenyl)methyl]-9-butyl-9H-pur...)
Affinity DataEC50:  8.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20752(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-{2-[(2-meth...)
Affinity DataEC50:  100nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20798(9-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-6-meth...)
Affinity DataEC50:  1.80E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20764(9-butyl-8-[(7-ethoxy-1,3-benzothiazol-2-yl)sulfany...)
Affinity DataEC50:  1.00E+5nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20746(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-(4-methylpe...)
Affinity DataEC50:  370nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20765(8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9-eth...)
Affinity DataEC50:  200nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20778(CHEMBL215657 | 8-[(7-chloro-1,3-benzothiazol-2-yl)...)
Affinity DataEC50:  35nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20797(9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]-9H-puri...)
Affinity DataEC50:  5.00E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20743(9-butyl-8-[(2-iodo-5-methoxyphenyl)methyl]-9H-puri...)
Affinity DataEC50:  5.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20791(6-chloro-9-[(2-iodo-3,4,5-trimethoxyphenyl)methyl]...)
Affinity DataEC50:  340nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20808(6-chloro-9-[(4-iodo-3,5-dimethylpyridin-2-yl)methy...)
Affinity DataEC50:  9nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20749(9-[3-(butan-2-ylamino)propyl]-8-[(2-iodo-5-methoxy...)
Affinity DataEC50:  210nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20769(3-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Affinity DataEC50:  90nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20755(9-butyl-8-[(5-chloro-1,3-benzothiazol-2-yl)sulfany...)
Affinity DataEC50:  2.00E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20775(4-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Affinity DataEC50:  150nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20768(2-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Affinity DataEC50:  150nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20812(6-chloro-9-[(3,4,5-trimethylpyridin-2-yl)methyl]-9...)
Affinity DataEC50:  42nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20787(6-chloro-9-[(2,5-dimethoxyphenyl)methyl]-9H-purin-...)
Affinity DataEC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM20782(8-({7-bromopyrido[3,4-d][1,3]thiazol-2-yl}sulfanyl...)
Affinity DataEC50:  400nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed
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