Report error Found 955 with Last Name = 'cantin' and Initial = 'ld'
Affinity DataKi: 9.25E+4nMAssay Description:Inhibition of BSEP in Sprague-Dawley rat canalicular membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholate uptakeMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 0.0300nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 0.300nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 0.360nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 0.360nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 0.440nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 0.600nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 1.30nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 2nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 2nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 2nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 2nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 2.40nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 2.5nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 5.70nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 5.70nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 10nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 11.9nMpH: 5.5 T: 30°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Pennsylvania
University of Pennsylvania
Affinity DataIC50: 20.5nMpH: 5.5 T: 30°CAssay Description:The inhibition of HIV-1 protease activities were measured with peptide hydrolysis assays. The appearance of products and the corresponding loss of su...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bayer Pharmaceuticals
Curated by ChEMBL
Bayer Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human P2X3 receptor expressed in RLE cells assessed as inhibition of (alpha,beta)me-ATP-induced intracellular calcium level by...More data for this Ligand-Target Pair