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TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22040(Ro5-4864 | 4' Cl-diazepam | 4 -chlorodiazepam ...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to TSPO receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50378901(CHEMBL1672418)
Affinity DataKd:  10nMAssay Description:Binding affinity to human TSPOMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054139((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human TSPOMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50409615(CHEMBL5282701)
Affinity DataKd:  3.80nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex mitochondrial membrane incubated for 60 mins by liquid scintillation spectrometer ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50376928(CHEMBL259114)
Affinity DataKd:  10.5nMAssay Description:Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50376913(CHEMBL259353)
Affinity DataKd:  14.8nMAssay Description:Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
University of Siena

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataKd:  200nMAssay Description:Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140783(2-Hydroxymethyl-4-phenyl-quinoline-3-carboxylic ac...)
Affinity DataIC50: 0.000100nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140770(2-Aminomethyl-4-phenyl-quinoline-3-carboxylic acid...)
Affinity DataIC50: 0.00170nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140773(2-Bromomethyl-4-phenyl-quinoline-3-carboxylic acid...)
Affinity DataIC50: 0.0100nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140785(2-Methylaminomethyl-4-phenyl-quinoline-3-carboxyli...)
Affinity DataIC50: 0.0110nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140786(4-Phenyl-quinoline-3-carboxylic acid (3,5-bis-trif...)
Affinity DataIC50: 0.0300nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140772(2-Methyl-4-phenyl-quinoline-3-carboxylic acid 3,5-...)
Affinity DataIC50: 0.0750nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50418331(SPERGUALIN)
Affinity DataIC50: 0.0794nMAssay Description:Binding affinity to human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVasoactive intestinal polypeptide receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50435130(CHEMBL1893324)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity to human VPAC1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355784(CHEMBL1911623)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355785(CHEMBL1911624)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355781(CHEMBL1911620)
Affinity DataIC50: 0.140nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataIC50: 0.140nMAssay Description:Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataIC50: 0.190nMAssay Description:Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140774(2-Dimethylaminomethyl-4-phenyl-quinoline-3-carboxy...)
Affinity DataIC50: 0.220nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355786(CHEMBL1911625)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50335566(CHEMBL1651026 | Substance P [Sar9,Met(O2)11])
Affinity DataIC50: 0.320nMAssay Description:Binding affinity to human NK1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataIC50: 0.330nMAssay Description:Binding affinity to human NTS1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355783(CHEMBL1911622)
Affinity DataIC50: 0.340nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50060686(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009718(CHEMBL7550 | 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetraz...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50009718(CHEMBL7550 | 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetraz...)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50060685(9-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]q...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50131724(3-Chloromethyl-4-phenyl-quinoline-2-carboxylic aci...)
Affinity DataIC50: 0.450nMAssay Description:Inhibitory activity against specific binding of [3H]-CB 34 to peripheral benzodiazepine receptor in rat cortical membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.590nMAssay Description:Inhibitory concentration against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054126((E)-N-(4-chlorophenyl)-2-(2-(4-chlorophenyl)-1-oxo...)
Affinity DataIC50: 0.620nMAssay Description:Displacement of [3H]PK115 from peripheral benzodiazepine receptor in Sprague-Dawley rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054125(2-[2-(4-Chloro-phenyl)-1-oxo-1,2-dihydro-pyrrolo[3...)
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H]PK11195 from rat kidney peripheral benzodiazepine receptor (type 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGalanin receptor type 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50378616(GALANIN)
Affinity DataIC50: 0.770nMAssay Description:Binding affinity to human GAL1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009712(CHEMBL315104 | 5,7-Dimethyl-2-propyl-3-[2'-(2H-tet...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50009712(CHEMBL315104 | 5,7-Dimethyl-2-propyl-3-[2'-(2H-tet...)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50060688(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355782(CHEMBL1911621)
Affinity DataIC50: 0.830nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054125(2-[2-(4-Chloro-phenyl)-1-oxo-1,2-dihydro-pyrrolo[3...)
Affinity DataIC50: 0.900nMAssay Description:Displacement of [3H]PK115 from peripheral benzodiazepine receptor in Sprague-Dawley rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009719(L-158338 | CHEMBL296725 | 7-Methyl-2-propyl-3-[2'-...)
Affinity DataIC50: 1nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054126((E)-N-(4-chlorophenyl)-2-(2-(4-chlorophenyl)-1-oxo...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]PK11195 from rat kidney peripheral benzodiazepine receptor (type 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50333104(H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2 | NC(1-17)NH2 ...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human NOP receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM22567(CHEMBL511 | PYRILAMINE | 3H]pyrilamine | N-[2-(dim...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human histamine H1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140771(L-703606 | (cis)-N-(2-iodobenzyl)-2-benzhydrylquin...)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054125(2-[2-(4-Chloro-phenyl)-1-oxo-1,2-dihydro-pyrrolo[3...)
Affinity DataIC50: 1.70nMAssay Description:Displacement of [3H]Ro-5-4864 from rat kidney peripheral benzodiazepine receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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