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TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253852((2-amino-4-((4-methylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253308((2-amino-4-((4-(pyrimidin-2-yl)piperazin-1-yl)meth...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253307((2-amino-4-((4-(pyridin-2-yl)piperazin-1-yl)methyl...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253928((2-amino-4-((4-(4-(trifluoromethyl)phenyl)piperazi...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253927(4-(4-((5-amino-4-(4-chlorobenzoyl)thiophen-3-yl)me...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253926((2-amino-4-((4-(benzo[d][1,3]dioxol-5-yl)piperazin...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253925((2-amino-4-((4-p-tolylpiperazin-1-yl)methyl)thioph...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253892((2-amino-4-((4-(4-chlorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253891((2-amino-4-((4-(4-fluorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253890((2-amino-4-((4-benzylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253889((2-amino-4-((4-phenylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253888((2-amino-4-((4-cyclohexylpiperazin-1-yl)methyl)thi...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50080550((2-amino-4,5-dimethylthien-3-yl)-[3-(trifluorometh...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253852((2-amino-4-((4-methylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.20nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253308((2-amino-4-((4-(pyrimidin-2-yl)piperazin-1-yl)meth...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253307((2-amino-4-((4-(pyridin-2-yl)piperazin-1-yl)methyl...)
Affinity DataKd:  1.20nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253928((2-amino-4-((4-(4-(trifluoromethyl)phenyl)piperazi...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253927(4-(4-((5-amino-4-(4-chlorobenzoyl)thiophen-3-yl)me...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253926((2-amino-4-((4-(benzo[d][1,3]dioxol-5-yl)piperazin...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253925((2-amino-4-((4-p-tolylpiperazin-1-yl)methyl)thioph...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253892((2-amino-4-((4-(4-chlorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253891((2-amino-4-((4-(4-fluorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253890((2-amino-4-((4-benzylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253889((2-amino-4-((4-phenylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50253888((2-amino-4-((4-cyclohexylpiperazin-1-yl)methyl)thi...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50080550((2-amino-4,5-dimethylthien-3-yl)-[3-(trifluorometh...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202567(1-deoxy-1-{2-chloro-6-[N'-(5-methyl-isoxazole-3-ca...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202569(1-deoxy-1-{2-chloro-6-[N'-(5-phenyl-isoxazole-3-ca...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  160nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202568(N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3...)
Affinity DataEC50:  450nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202564(1-deoxy-1-{2-chloro-6-[N'-(5-methyl-thiophene-2-ca...)
Affinity DataEC50:  175nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202577(1-deoxy-1-{2-chloro-6-[N'-(furan-2-carbonyl)-hydra...)
Affinity DataEC50:  210nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202575(1-deoxy-1-{2-chloro-6-[N'-(2-thiophen-2-yl-acetyl)...)
Affinity DataEC50:  603nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202561(1-deoxy-1-[6-(N'-benzoylhydrazino)-9H-purin-9-yl]-...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202573(1-deoxy-1-{6-[N'-(pyridine-3-carbonyl)-hydrazino]-...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202565(N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3...)
Affinity DataEC50:  200nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202570(N'-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydr...)
Affinity DataEC50:  82nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202574(1-deoxy-1-{6-[N'-(5-bromo-furan-2-carbonyl)-hydraz...)
Affinity DataEC50:  369nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202562(1-deoxy-1-{6-[N'-(1-methyl-4-nitro-1H-imidazole-2-...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202578(N'-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydr...)
Affinity DataEC50:  273nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202576(1-deoxy-1-[6-(N'-benzoyl-hydrazino)-2-chloro-9H-pu...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202563(1-deoxy-1-[6-(N'-(4-chlorobenzoyl)hydrazino)-9H-pu...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202572(N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3...)
Affinity DataEC50:  359nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202571(1-deoxy-1-{6-[N'-(5-methyl-furan-2-carbonyl)-hydra...)
Affinity DataEC50:  227nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202566(N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3...)
Affinity DataEC50:  340nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50216395(isoquinolinesulfon-5-yl-{2-[4-(2-fluorophenyl)pipe...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50216402(N-(2-(4-(4-nitrophenyl)piperazin-1-yl)-2-oxoethyl)...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50216390(N-(2-(4-benzylpiperazin-1-yl)-2-oxoethyl)isoquinol...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50216397(isoquinolinesulfon-5-yl-{2-[4-(4-acetylphenyl)pipe...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50216409(N-(2-oxo-2-(4-phenethylpiperazin-1-yl)ethyl)isoqui...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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