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TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113782((10R,13S,17S)-17-hydroxy-13-methyl-10-(4-methylben...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113783((2R,4aS,10aR)-4a-benzyl-2-(chloroethynyl)-1,2,3,4,...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113780((2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315763((4bS,7R,8aR)-4b-benzyl-7-hydroxy-7-(prop-1-ynyl)-N...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50124614(5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315767((S)-5-allyl-9-(ethynyloxy)-10-methoxy-2,2,4-trimet...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113777((4aS,10aR)-4a-benzyl-7-hydroxy-3,4,4a,9,10,10a-hex...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315765((S)-5-allyl-10-ethynyl-2,2,4-trimethyl-2,5-dihydro...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315766((S)-9-methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM13775((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315764((S)-5-allyl-9-cyanato-10-methoxy-2,2,4-trimethyl-2...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049508(5-Bromo-4-methoxy-2-((1S,4R)-2,2,4-trimethyl-6-met...)
Affinity DataKi:  1.04E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344448(2-(1-(4-chlorobenzyl)-1H-benzo[d]imidazol-2-ylthio...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344444(3-amino-4-(4-(benzyloxy)-3-methoxyphenyl)-N-(5-chl...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049509((R)-5-bromo-2-((2,2-dimethyl-6-methylenecyclohexyl...)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344447(CHEMBL1780016 | methyl-5-(diethylcarbamoyl)-4-meth...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049506(5-Bromo-2-((1S,3R)-3-bromo-2,2-dimethyl-6-methylen...)
Affinity DataKi:  2.47E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049497(5-Bromo-2-((1R,3R)-3-bromo-2,2-dimethyl-6-methylen...)
Affinity DataKi:  3.21E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344449(CHEMBL1780018 | ethyl 4-(5-(4-tert-butylbenzyliden...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315768(5-bromo-4-methoxy-2-(((1S)-2,2,5-trimethyl-6-methy...)
Affinity DataKi:  4.11E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344450(1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((8-methyl-2-...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344446(CHEMBL1699130 | dimethyl-4,4'-(ethane-1,2-diylbis(...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344445(CHEMBL1780014 | N-(3-(1-(2-(2-(3-butoxyphenyl)quin...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344451((S)-N5-(1-(1H-indol-3-yl)-2-(isopentylamino)-2-oxo...)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  11.4nMAssay Description:Displacement of fluoromone from human glucocorticoid receptor LBD assessed as reduction of maximum polarization by fluorescence polarization assay re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344444(3-amino-4-(4-(benzyloxy)-3-methoxyphenyl)-N-(5-chl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344448(2-(1-(4-chlorobenzyl)-1H-benzo[d]imidazol-2-ylthio...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344447(CHEMBL1780016 | methyl-5-(diethylcarbamoyl)-4-meth...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344449(CHEMBL1780018 | ethyl 4-(5-(4-tert-butylbenzyliden...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344450(1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((8-methyl-2-...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344446(CHEMBL1699130 | dimethyl-4,4'-(ethane-1,2-diylbis(...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344445(CHEMBL1780014 | N-(3-(1-(2-(2-(3-butoxyphenyl)quin...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344451((S)-N5-(1-(1H-indol-3-yl)-2-(isopentylamino)-2-oxo...)
Affinity DataIC50:  2.13E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50389162(CHEMBL2064743)
Affinity DataEC50:  2.40E+3nMAssay Description:Binding affinity to PPARgamma LBD by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataEC50:  190nMAssay Description:Binding affinity to PPARgamma LBD by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataEC50:  26nMAssay Description:Binding affinity to PPARgamma LBD by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50389160(CHEMBL2064741)
Affinity DataEC50:  215nMAssay Description:Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50389161(CHEMBL2064742)
Affinity DataEC50:  5.45E+3nMAssay Description:Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50389162(CHEMBL2064743)
Affinity DataEC50:  2.40E+3nMAssay Description:Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataEC50:  120nMAssay Description:Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataEC50:  3.70nMAssay Description:Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50389160(CHEMBL2064741)
Affinity DataEC50:  467nMAssay Description:Agonist activity at PPARgamma LBD in human 293H DA cells after 16 hrs by TR-FRET activation reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50389162(CHEMBL2064743)
Affinity DataEC50:  594nMAssay Description:Agonist activity at PPARgamma LBD in human 293H DA cells after 16 hrs by TR-FRET activation reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at PPARgamma LBD in human 293H DA cells after 16 hrs by TR-FRET activation reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPeroxisome proliferator-activated receptor alpha(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50389161(CHEMBL2064742)
Affinity DataEC50:  1.14E+4nMAssay Description:Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor alpha(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataEC50:  5.53E+4nMAssay Description:Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor alpha(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50099491(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Affinity DataEC50:  1.80nMAssay Description:Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

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