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TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282598((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282605((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282602((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282606((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282607((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataIC50:  12nMAssay Description:Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...More data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282603((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005677(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Affinity DataIC50:  13nMAssay Description:Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50229526(CHEMBL279356)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282597((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50283786(CHEMBL328917 | {(R)-3-(6-Bromo-1,3-dioxo-1H,3H-ben...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282601((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061707((1-Aza-bicyclo[3.2.1]oct-5-yl)-[(Z)-methoxyimino]-...)
Affinity DataIC50:  28nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB)radioligand in human cloned Muscarinic acetylcholine receptor M3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50229691(CHEMBL23118)
Affinity DataIC50:  30nMAssay Description:Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50283785(CHEMBL98233 | {(R)-3-(1,3-Dioxo-1H,3H-benzo[de]iso...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061707((1-Aza-bicyclo[3.2.1]oct-5-yl)-[(Z)-methoxyimino]-...)
Affinity DataIC50:  31nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282604((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282599((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282610((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282600((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50229697(CHEMBL23721)
Affinity DataIC50:  48nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061707((1-Aza-bicyclo[3.2.1]oct-5-yl)-[(Z)-methoxyimino]-...)
Affinity DataIC50:  49nMAssay Description:In vitro affinity of the compound is evaluated, usingquinuclidynyl benzylate (QNB) radioligand in human cloned Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282596(4-[(3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-di...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061705((R)-1-Aza-bicyclo[2.2.2]oct-3-yl-[(Z)-methoxyimino...)
Affinity DataIC50:  60nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50229618(CHEMBL23335)
Affinity DataIC50:  75nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061705((R)-1-Aza-bicyclo[2.2.2]oct-3-yl-[(Z)-methoxyimino...)
Affinity DataIC50:  90nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282609((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  95nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061707((1-Aza-bicyclo[3.2.1]oct-5-yl)-[(Z)-methoxyimino]-...)
Affinity DataIC50:  99nMAssay Description:In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM46858(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Affinity DataIC50:  115nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50229688(CHEMBL276975)
Affinity DataIC50:  140nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50283783(CHEMBL330729 | {(S)-3-(1,3-Dioxo-1H,3H-benzo[de]is...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061705((R)-1-Aza-bicyclo[2.2.2]oct-3-yl-[(Z)-methoxyimino...)
Affinity DataIC50:  170nMAssay Description:In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282608((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50230645(CHEMBL434772)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061705((R)-1-Aza-bicyclo[2.2.2]oct-3-yl-[(Z)-methoxyimino...)
Affinity DataIC50:  180nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50283779(CHEMBL96018 | {(R)-3-(1,3-Dioxo-1,3-dihydro-isoind...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataIC50:  213nMAssay Description:In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061702((1R,3R,4R)-1-Aza-bicyclo[2.2.1]heptane-3-carbaldeh...)
Affinity DataIC50:  220nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50043745(CHEMBL47907 | {(R)-1-[(S)-3-Methyl-1-((S)-1-methyl...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50229667(CHEMBL23563)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061706((1-Aza-bicyclo[2.2.1]hept-4-yl)-[(Z)-methoxyimino]...)
Affinity DataIC50:  240nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50043755(CHEMBL416095 | {(S)-1-[(S)-3-Methyl-1-((S)-1-methy...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061706((1-Aza-bicyclo[2.2.1]hept-4-yl)-[(Z)-methoxyimino]...)
Affinity DataIC50:  300nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataIC50:  322nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50283779(CHEMBL96018 | {(R)-3-(1,3-Dioxo-1,3-dihydro-isoind...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061719((1R,3R,4R)-1-Aza-bicyclo[2.2.1]hept-3-yl-[(Z)-meth...)
Affinity DataIC50:  380nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50043750(CHEMBL45577 | {(R)-1-[(S)-3-Methyl-1-((S)-1-methyl...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50230639(CHEMBL23172)
Affinity DataIC50:  430nMAssay Description:Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061706((1-Aza-bicyclo[2.2.1]hept-4-yl)-[(Z)-methoxyimino]...)
Affinity DataIC50:  495nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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