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TargetRetinoic acid receptor alpha [200-419]/gamma [183-417](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36811(BMS614)
Affinity DataKi:  1nM ΔG°:  -47.8kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor alpha [200-419]/gamma [183-417](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36810(BMS753 | US9963439, BMS753)
Affinity DataKi:  1nM ΔG°:  -47.8kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor gamma [183-417](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM31889(BMS 961 | BMS270394 | BMS961)
Affinity DataKi:  1.5nM ΔG°:  -46.8kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetRetinoic acid receptor alpha [200-419](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36810(BMS753 | US9963439, BMS753)
Affinity DataKi:  2nM ΔG°:  -46.2kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor alpha [200-419](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36811(BMS614)
Affinity DataKi:  2.5nM ΔG°:  -45.6kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB


LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...)
Affinity DataIC50:  60nMAssay Description:Displacement of [3H]-baclofen from Gamma-aminobutyric acid type B receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGamma-aminobutyric acid receptor subunit alpha-1(Mouse)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50001561(5-(6-Imino-3-thiophen-3-yl-6H-pyridazin-1-ylmethyl...)
Affinity DataIC50:  88nMAssay Description:Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1(Mouse)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50001562(5-(6-Imino-3-phenyl-6H-pyridazin-1-ylmethyl)-isoxa...)
Affinity DataIC50:  240nMAssay Description:Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1(Mouse)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50001556(4-(6-Imino-5-methyl-3-phenyl-6H-pyridazin-1-yl)-bu...)
Affinity DataIC50:  800nMAssay Description:Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50021125(5-Aminomethyl-3-hydroxy-cyclohex-2-enone | CHEMBL3...)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [3H]-baclofen from Gamma-aminobutyric acid type B receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50003624((RS)-nipecotic acid | CHEMBL277498 | Nipecotic | P...)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [3H]-baclofen from Gamma-aminobutyric acid type B receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed