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TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065118(CHEMBL311931 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50078646(CHEMBL49322 | N-[4-(4,10-Dihydro-1-thia-9-aza-benz...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of [3H]-AVP binding to human V2 receptor from murine fibroblast cell line (LV2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065123(CHEMBL420031 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065121(CHEMBL310416 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-AVP binding to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50078656(CHEMBL46295 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1nMAssay Description:Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50078652(CHEMBL301788 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of [3H]-AVP binding to human V2 receptor from murine fibroblast cell line (LV2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087550(Biphenyl-2-carboxylic acid [3-chloro-4-(5,6,7,8-te...)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity to rat V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087670(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-methy...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087541(Biphenyl-2-carboxylic acid [4-(5H,11H-benzo[e]pyrr...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to rat V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065124(CHEMBL68085 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50078660(CHEMBL299532 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of JAK2 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087551(Biphenyl-2-carboxylic acid [3-chloro-4-(4,5-dihydr...)
Affinity DataIC50:  1.70nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50078651(CHEMBL300963 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065111(CHEMBL80029 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065112(CHEMBL81269 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065125(CHEMBL311230 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065129(CHEMBL312036 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087664(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-dimet...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50024903(6-Chloro-3-(4-imidazol-1-yl-butyl)-1H-quinazoline-...)
Affinity DataIC50:  2nMAssay Description:Tested for inhibition of thromboxane synthetase from spontaneously hypertensive ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50024948(6-Chloro-3-(7-imidazol-1-yl-heptyl)-1H-quinazoline...)
Affinity DataIC50:  2nMAssay Description:Tested for inhibition of thromboxane synthetase from spontaneously hypertensive ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332622(CHEMBL1630782 | N-Methyl-N-((1S,2R,5S)-2-methyl-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173291((5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against [3H]-AVP binding to human vasopressin V1a receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065128(CHEMBL81133 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087675(Biphenyl-2-carboxylic acid [4-(3-[1,4']bipiperidin...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity to rat V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087552(Biphenyl-2-carboxylic acid [4-(5H,11H-benzo[e]pyrr...)
Affinity DataIC50:  2.60nMAssay Description:Binding affinity to rat V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087674(Biphenyl-2-carboxylic acid [3-chloro-4-(3-{[(2-dim...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087541(Biphenyl-2-carboxylic acid [4-(5H,11H-benzo[e]pyrr...)
Affinity DataIC50:  2.70nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173297((5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against [3H]-AVP binding to human vasopressin V1a receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50078654(CHEMBL297990 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of (P[3H]-AVP binding towards isolated rat kidney medullary Vasopre ssin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50024934(7-Chloro-3-(3-imidazol-1-yl-2-methyl-propyl)-1H-qu...)
Affinity DataIC50:  3nMAssay Description:Tested for inhibition of thromboxane synthetase from spontaneously hypertensive ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rat)
Medical Research Division of American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50024906(3-(3-Imidazol-1-yl-2-methyl-propyl)-6-methyl-1H-qu...)
Affinity DataIC50:  3nMAssay Description:Tested for inhibition of thromboxane synthetase from spontaneously hypertensive ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity to rat V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087543(Biphenyl-2-carboxylic acid [4-(2-chloro-5,6,7,8-te...)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity to rat V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.20nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of JAK3 by solution phase kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087552(Biphenyl-2-carboxylic acid [4-(5H,11H-benzo[e]pyrr...)
Affinity DataIC50:  3.40nMAssay Description:In vitro binding affinity for rat V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087542(CHEMBL350089 | N-[3-Chloro-4-(5,6,7,8-tetrahydro-t...)
Affinity DataIC50:  3.40nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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