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TargetNonstructural protein 3(Zika virus)
University of Patras

Curated by ChEMBL
LigandPNGBDBM50528559(CHEMBL4434998)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of N-terminal His-tagged Zika virus NS2B (46 to 99 residues) - NS3 (1 to 187 residues) protease domain expressed in Rosetta2-(DE3) assesse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240209(CHEMBL4068526)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240227(CHEMBL4084391)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity was determined against HSV-1 Ribonucleoside diphosphate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549539(US11306071, Compound 115 | US11306071, Compound 12...)
Affinity DataIC50: <0.600nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549471(US11306071, Compound 98)
Affinity DataIC50:  0.800nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240213(CHEMBL4085366)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549529(US11306071, Compound 104)
Affinity DataIC50:  0.900nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240224(CHEMBL4095856)
Affinity DataIC50:  1nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549548(US11306071, Compound 123)
Affinity DataIC50:  1.10nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549540(US11306071, Compound 116 | US11306071, Compound 12...)
Affinity DataIC50:  1.10nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549528(US11306071, Compound 102 | US11306071, Compound 10...)
Affinity DataIC50:  1.20nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549550(US11306071, Compound 125 | US11306071, Compound 12...)
Affinity DataIC50:  1.20nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549531(US11306071, Compound 108)
Affinity DataIC50:  1.30nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549536(US11306071, Compound 112)
Affinity DataIC50:  1.60nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM501684(US11028058, Compound 1.309)
Affinity DataIC50:  1.60nMAssay Description:For the A2A adenosine receptor radioligand binding assay, the following modifications were made to the general protocol. GF/C filters (Perkin Elmer, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549527(US11306071, Compound 100)
Affinity DataIC50:  1.60nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240216(CHEMBL4074076)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549552(US11306071, Compound 126)
Affinity DataIC50:  1.80nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549528(US11306071, Compound 102 | US11306071, Compound 10...)
Affinity DataIC50:  1.90nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549550(US11306071, Compound 125 | US11306071, Compound 12...)
Affinity DataIC50:  2nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50199118(CHEMBL3894825)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC6 (unknown origin) assessed as inhibition of fluorogenic peptide deacetylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240226(CHEMBL4065459)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against HSV-1 Ribonucleoside diphosphate reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM501676(US11028058, Compound 1.271)
Affinity DataIC50:  2.10nMAssay Description:For the A2A adenosine receptor radioligand binding assay, the following modifications were made to the general protocol. GF/C filters (Perkin Elmer, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM501677(US11028058, Compound 1.292)
Affinity DataIC50:  2.40nMAssay Description:For the A2A adenosine receptor radioligand binding assay, the following modifications were made to the general protocol. GF/C filters (Perkin Elmer, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549394(US11306071, Compound 75)
Affinity DataIC50:  2.5nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM539111(US11254670, Compound 1)
Affinity DataIC50:  2.60nMAssay Description:A second A2A adenosine receptor radioligand binding assay protocol was used. The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)
Affinity DataIC50:  2.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)
Affinity DataIC50:  2.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)
Affinity DataIC50:  2.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280366(2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-py...)
Affinity DataIC50:  2.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549534(US11306071, Compound 110)
Affinity DataIC50:  2.90nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50405402(CHEMBL5267945)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50405407(CHEMBL5285361)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549526(US11306071, Compound 2-10)
Affinity DataIC50:  3.10nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549375(US11306071, Compound 73)
Affinity DataIC50:  3.10nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM501679(US11028058, Compound 1.290)
Affinity DataIC50:  3.30nMAssay Description:For the A2A adenosine receptor radioligand binding assay, the following modifications were made to the general protocol. GF/C filters (Perkin Elmer, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549399(US11306071, Compound 76)
Affinity DataIC50:  3.40nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549538(US11306071, Compound 114)
Affinity DataIC50:  3.5nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM539137(US11254670, Compound 7)
Affinity DataIC50:  3.5nMAssay Description:A second A2A adenosine receptor radioligand binding assay protocol was used. The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549525(US11306071, Compound 2-6)
Affinity DataIC50:  3.70nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)
Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280369(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{7H-...)
Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)
Affinity DataIC50:  3.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280369(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{7H-...)
Affinity DataIC50:  3.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280369(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{7H-...)
Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)
Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)
Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280369(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{7H-...)
Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549549(US11306071, Compound 124)
Affinity DataIC50:  3.70nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549533(US11306071, Compound 109)
Affinity DataIC50:  3.80nMAssay Description:The protocol used adenosine A2a (human) membrane (PerkinElmer RBHA2AM400UA) at a concentration of 5 μg/well/100 μl and the radioligand [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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