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LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 1 alpha1/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 2 alpha1/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 3 alpha1/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-AMP-activated protein kinase subunit gamma-2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  118nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 5 alpha1/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  2.86E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 6 alpha1/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 9 alpha2/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-AMP-activated protein kinase subunit gamma-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 10 alpha2/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 11 alpha2/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246123(CHEMBL4066431)
Affinity DataEC50:  8.10E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246124(CHEMBL4097407)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246125(CHEMBL4078587)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246126(CHEMBL4077813)
Affinity DataEC50:  8.50E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246133(CHEMBL4064094)
Affinity DataEC50:  6.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246141(CHEMBL4093406)
Affinity DataEC50:  8.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246142(CHEMBL4071905)
Affinity DataEC50:  7.40E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246143(CHEMBL4071467)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246144(CHEMBL4066650)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246153(CHEMBL4071158)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246154(CHEMBL4091973)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246155(CHEMBL4078549)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246156(CHEMBL4104303)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246157(CHEMBL4071175)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246158(CHEMBL3393128)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50195475(CHEMBL3393127)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 4 alpha1/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 8 alpha2/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 12 alpha2/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246159(CHEMBL4090039)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246160(CHEMBL4061943)
Affinity DataEC50:  3.60E+4nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246161(CHEMBL4088692)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of human PXR transfected in human hepatoma cells assessed as induction of CYP3A4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246171(CHEMBL4066628)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536791(CHEMBL4579711)
Affinity DataEC50:  5.40E+3nMAssay Description:Inverse agonist activity at GAL4-fused human RORa expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536792(CHEMBL4527418)
Affinity DataEC50:  1.30E+3nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536793(CHEMBL4537920)
Affinity DataEC50:  120nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536791(CHEMBL4579711)
Affinity DataEC50:  47nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536794(CHEMBL4573492)
Affinity DataEC50:  64nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536795(CHEMBL4522912)
Affinity DataEC50:  22nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536794(CHEMBL4573492)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at GAL4-fused human RORa expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536795(CHEMBL4522912)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at GAL4-fused human RORa expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536796(CHEMBL4560046)
Affinity DataEC50:  6.80E+3nMAssay Description:Inverse agonist activity at GAL4-fused human RORb expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536795(CHEMBL4522912)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at GAL4-fused human RORb expressed in HEK293 cells assessed as activation of basal transcriptional activity by dual-glo luci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536795(CHEMBL4522912)
Affinity DataEC50:  3nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536797(CHEMBL4573658)
Affinity DataEC50:  73nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536794(CHEMBL4573492)
Affinity DataEC50:  8nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536796(CHEMBL4560046)
Affinity DataEC50:  6nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536798(CHEMBL4519011)
Affinity DataEC50:  2nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536799(CHEMBL4524658)
Affinity DataEC50:  13nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50536800(CHEMBL4574964)
Affinity DataEC50:  410nMAssay Description:Inverse agonist activity at human RORc-LBD assessed as inhibition of SRC1 co-activator peptide recruitment by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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