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TargetMetabotropic glutamate receptor 2(Rat)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467052(CHEMBL4279401)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467053(CHEMBL4290744)
Affinity DataEC50:  159nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467054(CHEMBL4288731)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467054(CHEMBL4288731)
Affinity DataEC50:  330nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467055(CHEMBL4283963)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467056(CHEMBL4287326)
Affinity DataEC50:  14nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467057(CHEMBL4295230)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467058(CHEMBL4278070)
Affinity DataEC50:  314nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467052(CHEMBL4279401)
Affinity DataEC50:  13nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467057(CHEMBL4295230)
Affinity DataEC50:  274nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467058(CHEMBL4278070)
Affinity DataEC50:  1.36E+3nMAssay Description:Positive allosteric modulation of recombinant human Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50467053(CHEMBL4290744)
Affinity DataEC50:  250nMAssay Description:Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50582730(CHEMBL5087055)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to human LRRK2 WT expressed in mammalian system assessed as dissociation constant measured at 1 uM by DiscoveRx KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
LigandPNGBDBM50582731(CHEMBL5092087)
Affinity DataKd:  6.60nMAssay Description:Binding affinity to human LRRK2 WT expressed in mammalian system assessed as dissociation constant measured at 1 uM by DiscoveRx KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
LigandPNGBDBM50582730(CHEMBL5087055)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to human LRRK2 (H970/E2527) G2019S mutant expressed in mammalian system assessed as dissociation constant measured at 1 uM by Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
LigandPNGBDBM50582731(CHEMBL5092087)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human LRRK2 (H970/E2527) G2019S mutant expressed in mammalian system assessed as dissociation constant measured at 1 uM by Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50582730(CHEMBL5087055)
Affinity DataKd:  470nMAssay Description:Binding affinity to human FLT3 ITD, D835V (V592/Y969) mutant expressed in mammalian system assessed as dissociation constant measured at 1 uM by Disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50582731(CHEMBL5092087)
Affinity DataKd:  67nMAssay Description:Binding affinity to human FLT3 ITD, D835V (V592/Y969) mutant expressed in mammalian system assessed as dissociation constant measured at 1 uM by Disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50582730(CHEMBL5087055)
Affinity DataKd:  850nMAssay Description:Binding affinity to human PIK4CB (M1/M828) WT expressed in mammalian system assessed as dissociation constant measured at 1 uM by DiscoveRx KINOMEsca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50582731(CHEMBL5092087)
Affinity DataKd:  730nMAssay Description:Binding affinity to human PIK4CB (M1/M828) WT expressed in mammalian system assessed as dissociation constant measured at 1 uM by DiscoveRx KINOMEsca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413552(CHEMBL472289)
Affinity DataEC50:  6.31nMAssay Description:Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413562(CHEMBL469375)
Affinity DataEC50:  63.1nMAssay Description:Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413563(CHEMBL469376)
Affinity DataEC50:  25.1nMAssay Description:Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413566(CHEMBL470849)
Affinity DataEC50:  15.8nMAssay Description:Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412441(SB-744185 | CHEMBL490417)
Affinity DataEC50:  7.94nMAssay Description:Inhibition of human ERG current by whole cell electrophysiology studyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412441(SB-744185 | CHEMBL490417)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417427(CHEMBL1290716)
Affinity DataEC50:  0.0316nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417410(CHEMBL1290596)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417421(CHEMBL1290597)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417412(CHEMBL1289047)
Affinity DataEC50:  501nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417422(CHEMBL1289048)
Affinity DataEC50:  63.1nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417410(CHEMBL1290596)
Affinity DataEC50:  5.01nMAssay Description:Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417427(CHEMBL1290716)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417423(CHEMBL1289164)
Affinity DataEC50:  316nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50203652(CHEMBL3909872)
Affinity DataEC50:  35nMAssay Description:Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208064(CHEMBL3933619)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR40 assessed as induction of IP1 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50208071(CHEMBL3964985)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208084(US9708270, 8 | CHEMBL3977361)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208093(US9708270, 25 | CHEMBL3953289)
Affinity DataEC50:  480nMAssay Description:Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208108(US9708270, 33 | CHEMBL3954140)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50208095(CHEMBL3919973)
Affinity DataEC50:  54nMAssay Description:Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50208108(US9708270, 33 | CHEMBL3954140)
Affinity DataEC50:  4.20E+3nMAssay Description:Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208146(US9708270, 38 | CHEMBL3901994)
Affinity DataEC50:  420nMAssay Description:Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208147(CHEMBL3949142)
Affinity DataEC50:  2.20E+3nMAssay Description:Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50208148(US9708270, 7 | CHEMBL3891920)
Affinity DataEC50:  49nMAssay Description:Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50208149(US9708270, 11 | CHEMBL3937916)
Affinity DataEC50:  670nMAssay Description:Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208150(US9708270, 16 | CHEMBL3947837)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208151(US9708270, 97 | CHEMBL3986483)
Affinity DataEC50:  5.70E+3nMAssay Description:Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208159(CHEMBL3928591)
Affinity DataEC50:  4.40E+3nMAssay Description:Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208160(CHEMBL3940359)
Affinity DataEC50:  580nMAssay Description:Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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