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LigandPNGBDBM50506814(CHEMBL4513619)
Affinity DataKd:  1.08E+4nMAssay Description:Binding affinity to PRMT5 (unknown origin)/MEP50 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlbumin(Human)
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50569288(CHEMBL4850435)
Affinity DataKd:  363nMAssay Description:Binding affinity to human serum albumin assessed as dissociation constant by fluorescence emission spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAlbumin(Human)
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50569289(PYROPHEOPHORBIDE A | CHEBI:48398)
Affinity DataKd:  89nMAssay Description:Binding affinity to human serum albumin assessed as dissociation constant by fluorescence emission spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlbumin(Human)
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50366944(Azovan Blue | Azovan sodium | EVANS BLUE)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to human serum albumin assessed as dissociation constant by fluorescence emission spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585016(CHEMBL5085606)
Affinity DataEC50:  1.70E+4nMAssay Description:Induction of degradation of human ERalpha in MCF7 cells irradiated with 460 light for 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEstrogen receptor(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585016(CHEMBL5085606)
Affinity DataEC50:  500nMAssay Description:Induction of degradation of human ERalpha in MCF7 cells irradiated with 460 light for 45 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  99nMAssay Description:Agonist activity at FXR (unknown origin) by fluorescence resonance energy tranfer assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  85nMAssay Description:Agonist activity at full length FXR in human Huh-7 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  37nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24566(JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro...)
Affinity DataEC50:  630nMAssay Description:Agonist activity at mouse PPARalphaMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.50E+7nMAssay Description:Agonist activity at mouse PPARalphaMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM28701(Cedur | 2-(4-{2-[(4-chlorophenyl)formamido]ethyl}p...)
Affinity DataEC50:  5.00E+7nMAssay Description:Agonist activity at mouse PPARalphaMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24566(JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at human PPARalphaMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50244350(CHEMBL4091374)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human PPARalphaMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50085042(Finofibrate | Tricor (TN) | CHEMBL672 | propan-2-y...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50110590(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid...)
Affinity DataEC50:  1.52E+7nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50214899((R)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at Gal4-fused PPARalpha LBD (unknown origin) transfected in human HepG2 cells assessed as transcriptional activation incubated for 2...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50428854(CHEMBL1236924)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50502541(Elafibranor | GFT-505 | Gft505)
Affinity DataEC50:  45nMAssay Description:Agonist activity at PPARalpha (unknown origin) assessed as transcriptional activationMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50502541(Elafibranor | GFT-505 | Gft505)
Affinity DataEC50:  175nMAssay Description:Agonist activity at PPARgamma (unknown origin) assessed as transcriptional activationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50615692(Saroglitazar | SAROGLITAZAR)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at PPARalpha in human HepG2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50615693(Lobeglitazone | LOBEGLITAZONE)
Affinity DataEC50:  3nMAssay Description:Agonist activity at PPARgamma in human HepG2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor delta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50244350(CHEMBL4091374)
Affinity DataEC50:  870nMAssay Description:Agonist activity at human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50244350(CHEMBL4091374)
Affinity DataEC50:  210nMAssay Description:Agonist activity at human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50615693(Lobeglitazone | LOBEGLITAZONE)
Affinity DataEC50:  2.00E+4nMAssay Description:Binding affinity to PPARalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50030474(US9562012, rosiglitazone | CHEBI:50122 | Avandamet...)
Affinity DataEC50:  300nMAssay Description:Binding affinity to PPARgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor delta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50085041({4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor delta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50213714((R)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)p...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620488(CHEMBL5414697)
Affinity DataKd:  1.19E+4nMAssay Description:Binding affinity to Keap1 (unknown origin) assessed as dissociation constant incubated for 200 sec by sensor chip immobilization based surface plasmo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataKd:  4.87E+4nMAssay Description:Binding affinity to Keap1 (unknown origin) assessed as dissociation constant incubated for 200 sec by sensor chip immobilization based surface plasmo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataKd:  169nMAssay Description:Inhibition of Keap1-Nrf2 protein-protein interaction (unknown origin) measured after 60 mins by FITC-betaAla-DEETGEF-OH probe based fluorescent polar...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataKd:  1.51E+3nMAssay Description:Binding affinity to NuR77-LBD receptor expressed in human BGC823 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataEC50:  0.115nMAssay Description:Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-LBD assessed as transactivation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataEC50:  0.278nMAssay Description:Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-Nur77 assessed as transactivation af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM31892(CHEMBL705 | 9-cis retinoic acid | alitretinoin | P...)
Affinity DataKd:  240nMAssay Description:Binding affinity to RXRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataKd:  740nMAssay Description:Binding affinity to Nur77 receptor expressed in human BGC823 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50111599(CHEMBL3605083)
Affinity DataEC50:  16nMAssay Description:Agonist activity at APC-labeled RORgammat-LBD (unknown origin) assessed as induction of europium-labeled SRC1 recruitment after 1 hr by dual FRET ana...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50111683(CHEMBL3605080)
Affinity DataEC50:  3.98E+3nMAssay Description:Agonist activity at APC-labeled RORgammat-LBD (unknown origin) assessed as induction of europium-labeled SRC1 recruitment after 1 hr by dual FRET ana...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50111684(CHEMBL3605079)
Affinity DataEC50:  3.16E+3nMAssay Description:Agonist activity at APC-labeled RORgammat-LBD (unknown origin) assessed as induction of europium-labeled SRC1 recruitment after 1 hr by dual FRET ana...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50567288(CHEMBL4865838)
Affinity DataIC50: 0.0510nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50567287(CHEMBL4862360)
Affinity DataIC50: 0.0580nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM250014(US9447106, 136 | US9556188, Compound 136 | US10005...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM249934(US9447106, 63 | US9556188, Compound 63 | US1000578...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM250014(US9447106, 136 | US9556188, Compound 136 | US10005...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM249934(US9447106, 63 | US9556188, Compound 63 | US1000578...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
University of Jinan

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5 expressed in Sf9 insect cells using histone H2A as peptide after 120 mins in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM249925(US9447106, 52 | US9556188, Compound 52 | US1000578...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM249925(US9447106, 52 | US9556188, Compound 52 | US1000578...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM249997(US9447106, 123 | US9556188, Compound 123 | US10005...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM249997(US9447106, 123 | US9556188, Compound 123 | US10005...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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