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TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242602(CHEMBL4073693)
Affinity DataEC50:  1.50E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242574(CHEMBL4062299)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242586(CHEMBL4092581)
Affinity DataEC50:  500nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242587(CHEMBL4097866)
Affinity DataEC50:  290nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242588(CHEMBL4090149)
Affinity DataEC50:  1.60E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242589(CHEMBL4062125)
Affinity DataEC50:  5.50E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242590(CHEMBL4089219)
Affinity DataEC50:  9.90E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242591(CHEMBL4070751)
Affinity DataEC50:  500nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242592(CHEMBL4066153)
Affinity DataEC50:  1.39E+4nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242552(CHEMBL4087521)
Affinity DataEC50:  1.12E+4nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242603(CHEMBL4099244)
Affinity DataEC50:  260nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242604(CHEMBL4063645)
Affinity DataEC50:  1.40E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242605(CHEMBL4089637)
Affinity DataEC50:  3.60E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242606(CHEMBL4071219)
Affinity DataEC50:  340nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242607(CHEMBL4084011)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242574(CHEMBL4062299)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242551(CHEMBL4081345)
Affinity DataEC50:  720nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242573(CHEMBL4068807)
Affinity DataEC50:  280nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM48569(N-(3-chlorophenyl)-5-propan-2-yl-1,2-oxazole-3-car...)
Affinity DataEC50:  860nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242553(CHEMBL4074761)
Affinity DataEC50:  3.56E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242554(CHEMBL4092778)
Affinity DataEC50:  1.93E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242555(CHEMBL4100508)
Affinity DataEC50:  8.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242559(CHEMBL4091509)
Affinity DataEC50:  170nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242560(CHEMBL4081226)
Affinity DataEC50:  2.60E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242561(CHEMBL4060907)
Affinity DataEC50:  780nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM56067(MLS000087329 | 5-propan-2-yl-N-(3-pyridinyl)-3-iso...)
Affinity DataEC50:  9.90E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242562(CHEMBL4085268)
Affinity DataEC50:  360nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242563(CHEMBL4097356)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242564(CHEMBL4079330)
Affinity DataEC50:  5.40E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242569(CHEMBL4068510)
Affinity DataEC50:  7.30E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242570(CHEMBL4081762)
Affinity DataEC50:  2.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242571(CHEMBL4059844)
Affinity DataEC50:  6.20E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242572(CHEMBL4098258)
Affinity DataEC50:  260nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232526(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237216(CHEMBL4080254)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237201(CHEMBL4082618)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237200(CHEMBL4072132)
Affinity DataIC50: 0.0690nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM36530(D157493)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237199(CHEMBL4077061)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237203(CHEMBL250072)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237205(CHEMBL398675)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237209(CHEMBL4062544)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237211(CHEMBL4061457)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237210(CHEMBL399673)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM36534(D156095)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237217(CHEMBL342595)
Affinity DataIC50: 1nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237202(CHEMBL4103454)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
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