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TargetProlyl endopeptidase(Flavobacterium meningosepticum)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50038879(JTP-4819 | CHEMBL79993 | (S)-2-(2-Formyl-pyrrolidi...)
Affinity DataIC50: 1.27nMAssay Description:Inhibition of Flavobacterium meningosepticum propyl endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM601762(US11643395, Compound 8)
Affinity DataIC50: 26.2nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetThymidine phosphorylase(Escherichia coli (strain K12))
University of Karachi

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Inhibition of Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tribhuvan University

Curated by ChEMBL
LigandPNGBDBM50004000(CHEMBL94 | physostigmine | Antilirium | Eserine | ...)
Affinity DataIC50: 41nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tribhuvan University

Curated by ChEMBL
LigandPNGBDBM50004000(CHEMBL94 | physostigmine | Antilirium | Eserine | ...)
Affinity DataIC50: 41nMAssay Description:Inhibition of electric eel AChE by modified Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 50nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM601756(US11643395, Compound 1)
Affinity DataIC50: 100nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Bovine)
Universiti Teknologi Mara (Uitm)

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataIC50: 180nMpH: 7.2Assay Description:This was assay performed using buffer containing Tris and HEPES at the pH of 7.2-7.9 and a total concentration of 20 mM. 96-well plates were filled w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2016
Entry Details Article
PubMed
TargetEnoyl-ACP reductase(malaria parasite P. falciparum)
University of Yaounde

Curated by ChEMBL
LigandPNGBDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate peincubated for 5 mins measured after 10 mins of substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
Tribhuvan University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 250nMAssay Description:Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 10 mins by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM601758(US11643395, Compound 3)
Affinity DataIC50: 400nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM50272555(sarcovagine C | CHEMBL504924)
Affinity DataIC50: 400nMAssay Description:Inhibition of butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM601757(US11643395, Compound 2)
Affinity DataIC50: 500nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetAcetylcholinesterase(Electric eel)
Tribhuvan University

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against AChE from electric eelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM50272517(chonemorphine | CHEMBL498645)
Affinity DataIC50: 500nMAssay Description:Inhibition of butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Bielefeld University

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 500nMAssay Description:Inhibition of acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tribhuvan University

Curated by ChEMBL
LigandPNGBDBM50259930(6-[10'(Z)-heptade-cenyljsalicylic acid | 6-(10'Z-h...)
Affinity DataIC50: 573nMAssay Description:Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 10 mins by Ellman's spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM50272519(epipachysamine-E-5-en-4-one | CHEMBL496259)
Affinity DataIC50: 600nMAssay Description:Inhibition of butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019208(CHEMBL137922)
Affinity DataIC50: 600nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 670nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM601760(US11643395, Compound 6)
Affinity DataIC50: 700nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019283(CHEMBL3289121)
Affinity DataIC50: 700nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCholinesterase(Horse)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50512782(CHEMBL4462721)
Affinity DataIC50: 800nMAssay Description:Inhibition of equine serum BChE using butyrylcholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM50272489((20S)-20-(N,N-dimethylamino)-3beta-(N-senecoylamin...)
Affinity DataIC50: 800nMAssay Description:Inhibition of butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCholinesterase(Horse)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50004000(CHEMBL94 | physostigmine | Antilirium | Eserine | ...)
Affinity DataIC50: 857nMAssay Description:Inhibition of horse BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM50004000(CHEMBL94 | physostigmine | Antilirium | Eserine | ...)
Affinity DataIC50: 857nMAssay Description:Inhibition of BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tribhuvan University

Curated by ChEMBL
LigandPNGBDBM50176468(haloxysterol B | CHEMBL202223)
Affinity DataIC50: 890nMAssay Description:Inhibitory activity against AChE from electric eelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50028013(CHEMBL3360798)
Affinity DataIC50: 900nMAssay Description:Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide substrate incubated for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50237975(CHEMBL4098314)
Affinity DataIC50: 960nMAssay Description:Inhibition of bovine xanthine oxidase using xanthine as substrate preincubated for 10 mins followed by substrate addition measured for 15 mins by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2019
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Tribhuvan University

Curated by ChEMBL
LigandPNGBDBM50176465(haloxysterol C | CHEMBL382961)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against AChE from electric eelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Horse)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50512776(CHEMBL4471134)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of equine serum BChE using butyrylcholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019166(CHEMBL336718)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019203(CHEMBL3289115 | 2-(3'-Ethoxy-4'-hydroxyphe...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCholinesterase(Horse)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50512783(CHEMBL4536564)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of equine serum BChE using butyrylcholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Universiti Teknologi Mara (Uitm)

LigandPNGBDBM222428(N'',N'''-Bis[(E)-(4-nitrophenyl)methylidene]ca...)
Affinity DataIC50: 1.33E+3nMpH: 7.4 T: 2°CAssay Description:In this assay, 4-nitrophenyl acetate (4-NPA), a colorless compound, was hydrolyzed to 4-nitrophenol and CO2. The reaction was followed by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Universiti Teknologi Mara (Uitm)

LigandPNGBDBM222430(N'',N'''-Bis[(E)-(2-chloro-5-nitrophenyl)methy...)
Affinity DataIC50: 1.37E+3nMpH: 7.4 T: 2°CAssay Description:In this assay, 4-nitrophenyl acetate (4-NPA), a colorless compound, was hydrolyzed to 4-nitrophenol and CO2. The reaction was followed by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Universiti Teknologi Mara (Uitm)

LigandPNGBDBM222435(N'',N'''-Bis[(E)-(2,6-dichlorophenyl)methylide...)
Affinity DataIC50: 1.46E+3nMpH: 7.4 T: 2°CAssay Description:In this assay, 4-nitrophenyl acetate (4-NPA), a colorless compound, was hydrolyzed to 4-nitrophenol and CO2. The reaction was followed by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2017
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019212(CHEMBL3289116)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM91713(Androst-4-en-3,17-dione, 2 | Androstenedione | And...)
Affinity DataIC50: 1.55E+3nMAssay Description:AChE and BChE inhibiting activities were measured in vitro by a modified spectrophotometric method previously developed by Ellman et. al.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM50272518(N-methypachysamine A | CHEMBL496255)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-glucuronidase(Bovine)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50008884(CHEMBL3237329)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetTyrosinase(Human)
University of Karachi

LigandPNGBDBM50218211(Tyrosinase Inhibitor, 4 | CHEMBL399558 | 1'-(4-Met...)
Affinity DataIC50: 1.72E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019285(CHEMBL3289122)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019286(CHEMBL3289123)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Universiti Teknologi Mara (Uitm)

LigandPNGBDBM222429(N'',N'''-Bis[(E)-(2-nitrophenyl)methylidene]ca...)
Affinity DataIC50: 1.85E+3nMpH: 7.4 T: 2°CAssay Description:In this assay, 4-nitrophenyl acetate (4-NPA), a colorless compound, was hydrolyzed to 4-nitrophenol and CO2. The reaction was followed by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Universiti Teknologi Mara (Uitm)

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataIC50: 1.86E+3nMpH: 7.4 T: 2°CAssay Description:In this assay, 4-nitrophenyl acetate (4-NPA), a colorless compound, was hydrolyzed to 4-nitrophenol and CO2. The reaction was followed by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2017
Entry Details Article
PubMed
TargetBeta-glucuronidase(Bovine)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50008901(CHEMBL2430239)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
LigandPNGBDBM50028010(CHEBI:10127 | AD-810 | CI-912 | PD-110843 | Zonegr...)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of carbonic anhydrase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50176470(24-ethyl-cholest-7-ene-3,5,6-triol | CHEMBL201951)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against BuChE from horse serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50140241(CHEBI:40279 | Allopurinol | Aloral | Aluline 100 |...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine xanthine oxidase using xanthine as substrate preincubated for 10 mins followed by substrate addition measured for 15 mins by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2019
Entry Details Article
PubMed
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