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TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606633(CHEMBL5219936)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50035612(CHEMBL96926 | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606639(CHEMBL5219016)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606640(CHEMBL5220467)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606641(CHEMBL5219752)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinic acetylcholine receptor alpha9/alpha10(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606633(CHEMBL5219936)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of rat alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response incubated for 5 mins in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606645(CHEMBL5220455)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606638(CHEMBL5220113)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50581244(CHEMBL5086734)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606644(CHEMBL5219791)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326748((3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-4-(butyrylo...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50581248(CHEMBL5090753)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor alpha9/alpha10(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606635(CHEMBL5220820)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of rat alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response incubated for 5 mins in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50165369(12-(4-Amino-4-carboxy-butyrylamino)-dodecanoic aci...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against sarco- endoplasmic reticulum calcium-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606650(CHEMBL5219058)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606637(CHEMBL5220002)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinic acetylcholine receptor alpha9/alpha10(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606636(CHEMBL5220778)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response incubated for 5 mins in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50544003(CHEMBL4647678)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response measured after 5 ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50581243(CHEMBL5089881)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor alpha9/alpha10(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606634(CHEMBL5220229)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response incubated for 5 mins in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326743((3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-4-(butyrylo...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50165368(CHEMBL191633 | Dodecanedioic acid mono-((2S,3aR,4S...)
Affinity DataIC50:  2.08nMAssay Description:Inhibitory activity against sarco- endoplasmic reticulum calcium-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606643(CHEMBL5218653)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326737((3S,3aR,4S,6S,6aR,7S,8S,9bS)-3,3a-dihydroxy-3,6,9-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50581249(CHEMBL5073182)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326751((3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-4-(butyrylo...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50544009(CHEMBL4644407)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response measured after 5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606642(CHEMBL5220060)
Affinity DataIC50:  4nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042058((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Affinity DataIC50:  5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472190(CHEMBL167638)
Affinity DataIC50:  5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50544008(CHEMBL4634686)
Affinity DataIC50:  5.90nMAssay Description:Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response measured after 5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50581246(CHEMBL5080428)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326749((3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-4-(butyrylo...)
Affinity DataIC50:  9nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326742((3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-3,3a,4-trih...)
Affinity DataIC50:  10nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326746((3S,3aR,4S,6S,6aR,7S,8S,9bS)-3a-hydroxy-3,6,9-trim...)
Affinity DataIC50:  11.1nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50544006(CHEMBL4634288)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response measured after 5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326739((3S,3aR,4S,6S,6aR,7S,8S,9bS)-4-(butyryloxy)-3,3a-d...)
Affinity DataIC50:  15.6nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326738((3S,3aR,4S,6S,6aR,7S,8S,9bS)-4-(butyryloxy)-3,3a-d...)
Affinity DataIC50:  16nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326750((3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetoxy-8-(2-(biphe...)
Affinity DataIC50:  18nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326745(CHEMBL1253588 | Octanoic acid(2aS,5aS,7S,7aR,8S,9S...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50165366(CHEMBL191927 | Pentanedioic acid mono-((2S,3aR,4S,...)
Affinity DataIC50:  19.8nMAssay Description:Inhibitory activity against sarco- endoplasmic reticulum calcium-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326736((3S,3aR,4S,6S,6aR,7S,8S,9bS)-3,3a,6-trihydroxy-3,6...)
Affinity DataIC50:  20nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530304(CHEMBL4445989)
Affinity DataIC50:  20nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530304(CHEMBL4445989)
Affinity DataIC50:  20nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326735((3S,3aR,4S,6S,6aR,7S,8S,9bS)-4-(butyryloxy)-3,3a,6...)
Affinity DataIC50:  20nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606648(CHEMBL5220622)
Affinity DataIC50:  24nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50326741((3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(2-(biphenyl-4-yl)a...)
Affinity DataIC50:  27nMAssay Description:Inhibition of rabbit sarcoplasmic reticulum calcium ATPase by ATP regeneration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530295(CHEMBL4453927)
Affinity DataIC50:  32nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530295(CHEMBL4453927)
Affinity DataIC50:  32nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50606646(CHEMBL5221023)
Affinity DataIC50: >33nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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