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TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228930((E)-2-(6-chloro-benzo[b]thiophen-2-yl)-ethenesulfo...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50572134(CHEMBL4868363)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228950((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50572127(CHEMBL4850335)
Affinity DataKi:  0.398nMAssay Description:Inhibition of human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228954((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263211(2-Cyclobutylamino-N-[4'-(cyclopropylmethyl-carbamo...)
Affinity DataKi:  0.600nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228940(6-chloro-N-(1-(4-(2-cyanopyridin-3-yl)-2-fluorophe...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50572130(CHEMBL4864027)
Affinity DataKi:  0.794nMAssay Description:Inhibition of human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50572131(CHEMBL4873236)
Affinity DataKi:  1nMAssay Description:Inhibition of human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228932(6-chloro-N-(1-(2-fluoro-4-(1-methyl-1H-imidazol-2-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228947(6-chloro-benzofuran-2-sulfonic acid [1-(3-fluoro-2...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
TargetTranscription initiation factor TFIID subunit 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50572133(CHEMBL4854161)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263261(5'-(3-Furan-3-yl-benzoylamino)-2'-methyl-biphenyl-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228935((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263129(CHEMBL477182 | N-[4'-(Cyclopropylmethyl-carbamoyl)...)
Affinity DataKi:  1.90nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263295(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-[(3-ter...)
Affinity DataKi:  1.90nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17654(5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.4 T: 22°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50147620(CHEMBL3769507)
Affinity DataKi:  2nMAssay Description:Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228941(5-chloro-thieno[3,2-b]pyridine-2-sulfonic acid [1-...)
Affinity DataKi:  2nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50359016(CHEMBL1924017)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263260(5'-[3-(2,5-Dimethyl-pyrrol-1-yl)-benzoylamino]-2'-...)
Affinity DataKi:  2.10nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228936(6-chloro-N-(1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263212(2-Cyclohexylamino-N-[4'-(cyclopropylmethyl-carbamo...)
Affinity DataKi:  3nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50359013(CHEMBL1924014)
Affinity DataKi:  3nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17641(5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 22°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17643((E)-2-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(m...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 22°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50359018(CHEMBL1924019)
Affinity DataKi:  4nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263168(CHEMBL476351 | N-[4'-(Cyclopropylmethyl-carbamoyl)...)
Affinity DataKi:  4.40nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228949(6-chloro-N-(1-(2-fluoro-4-(1H-imidazol-1-yl)phenyl...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263210(CHEMBL478234 | N-[4'-(Cyclopropylmethyl-carbamoyl)...)
Affinity DataKi:  4.60nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17653(2-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.4 T: 22°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263170(2-Cyclopropylamino-N-[4'-(cyclopropylmethyl-carbam...)
Affinity DataKi:  5.20nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50262865(CHEMBL477583 | Furan-3-carboxylic acid [4'-(cyclop...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263168(CHEMBL476351 | N-[4'-(Cyclopropylmethyl-carbamoyl)...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50359032(CHEMBL1924024)
Affinity DataKi:  6nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12538(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.4 T: 22°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228946((E)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(5-(2-(tr...)
Affinity DataKi:  6nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228953(5-chloro-benzofuran-2-sulfonic acid [1-(3-fluoro-2...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263209(2-(Cyclopropylmethyl-amino)-N-[4'-(cyclopropylmeth...)
Affinity DataKi:  6.30nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228951(6-chloro-N-(1-(2-fluoro-4-(pyridin-3-yl)phenyl)-2-...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKi:  6.40nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50359022(CHEMBL1924023)
Affinity DataKi:  8nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50359017(CHEMBL1924018)
Affinity DataKi:  8nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228945(6-chloro-N-(1-(2-fluoro-4-(pyridin-4-yl)phenyl)-2-...)
Affinity DataKi:  8.90nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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