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TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22876(Sch 29851 | Claritin | CHEMBL998 | ethyl 4-{13-chl...)
Affinity DataKd:  190nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545588(CHEMBL4647890)
Affinity DataKd:  48nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545589(CHEMBL4647038)
Affinity DataKd:  28nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073179(CHEMBL1172 | Clarinex | Claritin-D | Claritin | SC...)
Affinity DataKd:  24nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545590(CHEMBL4645629)
Affinity DataKd:  454nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545591(CHEMBL4639563)
Affinity DataKd:  257nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545592(CHEMBL4637657)
Affinity DataKd:  51nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545593(CHEMBL4638183)
Affinity DataKd:  227nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545594(CHEMBL4649344)
Affinity DataKd:  423nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545595(CHEMBL4633258)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031236(CHEMBL3357023)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545596(CHEMBL4633111)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545597(CHEMBL4643460)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545598(CHEMBL4649552)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545599(CHEMBL4642056)
Affinity DataKd:  454nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545600(CHEMBL4641273)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545601(CHEMBL4646840)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545602(CHEMBL4634510)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545603(CHEMBL4633975)
Affinity DataKd:  271nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031281(CHEMBL3357022)
Affinity DataKd:  199nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545604(CHEMBL4634809)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545605(CHEMBL4648718)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545606(CHEMBL4649329)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545607(CHEMBL4632879)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545608(CHEMBL4632720)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545609(CHEMBL4642460)
Affinity DataKd:  206nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataEC50:  3.20E+3nMAssay Description:Reduction of viral RNA and protein in Huh7 cells containing HCV sub-genomic repliconMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305734(N-(2-acetylphenyl)-N,4-dimethylbenzenesulfonamide ...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305733(N-(2-benzoyl-4-bromophenyl)-N,4-dimethylbenzenesul...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305732(N-(2-benzoyl-4-chlorophenyl)-N,4-dimethylbenzenesu...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305731(N,4-dimethyl-N-(2-(thiophene-3-carbonyl)phenyl)ben...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305740(N-(2-(indoline-1-carbonyl)phenyl)-N,4-dimethylbenz...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305738(1,4-ditosyl-1,2,3,4-tetrahydroquinoxaline | CHEMBL...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305737(N,N'-(1,2-phenylene)bis(N-allyl-4-methylbenzenesul...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305739(5,12-ditosyl-5,6,11,12-tetrahydrodibenzo[b,f][1,4]...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305736(N,N'-(1,2-phenylene)bis(N-methylbenzenesulfonamide...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(N,N'-(1,2-phenylene)bis(N-methyl-1-phenylmethanesu...)
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102479(4-[Carboxy-(4'-methylsulfanyl-biphenyl-4-sulfonyla...)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM30359(BOC-piperidinyl glycine derivative, 34)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102477(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102468(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102477(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102478(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-(2-me...)
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102468(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102477(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50: 0.800nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102474(4-{carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-methy...)
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102469(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102478(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-(2-me...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102482(4-[carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50102476(4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-m...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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