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LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataEC50:  231nMAssay Description:VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details

LigandPNGBDBM496896(science.abl4784, 2 | WO2021250648, Example 4 | US1...)
Affinity DataEC50:  1.36E+3nMAssay Description:VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details

LigandPNGBDBM496897(science.abl4784, 3)
Affinity DataEC50:  5.59E+3nMAssay Description:VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details

LigandPNGBDBM496900(science.abl4784, 4)
Affinity DataEC50:  909nMAssay Description:VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details

LigandPNGBDBM496901(science.abl4784, 5)
Affinity DataEC50:  85nMAssay Description:VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details

LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataEC50:  75nMAssay Description:VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details

TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240882(CHEMBL4063837)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human mu-type opioid receptor expressed in CHO-K1 cells assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.960nMAssay Description:Agonist activity at rat 5HT4L receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at rat 5HT4L receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at rat 5HT4L receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.360nMAssay Description:Agonist activity at human 5HT4B receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4B receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human 5HT4B receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at rat 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at rat 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at human 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at rat 5HT4S receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.620nMAssay Description:Agonist activity at rat 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.200nMAssay Description:Partial agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.470nMAssay Description:Agonist activity at human 5HT4A receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human 5HT4A receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.380nMAssay Description:Agonist activity at human 5HT4A receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398589(CHEMBL2179588)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398591(CHEMBL2179581)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398592(CHEMBL2179590)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398593(CHEMBL2179587)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398594(CHEMBL2179585)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398595(CHEMBL2179586)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398596(CHEMBL2179589)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at rat 5HT4S receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398597(CHEMBL2179584)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.590nMAssay Description:Agonist activity at rat 5HT4S receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398599(CHEMBL2179580)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM490009(US10966980, Example 263)
Affinity DataIC50: 0.00200nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM490011(US10966980, Example 265)
Affinity DataIC50: 0.00200nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489909(US10966980, Example 163)
Affinity DataIC50: 0.00300nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489965(US10966980, Example 219)
Affinity DataIC50: 0.00300nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489982(US10966980, Example 236)
Affinity DataIC50: 0.00300nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489983(US10966980, Example 237)
Affinity DataIC50: 0.00300nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489985(US10966980, Example 239)
Affinity DataIC50: 0.00300nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489960(US10966980, Example 214)
Affinity DataIC50: 0.00400nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489998(US10966980, Example 252)
Affinity DataIC50: 0.00400nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489916(US10966980, Example 170)
Affinity DataIC50: 0.00500nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489922(US10966980, Example 176)
Affinity DataIC50: 0.00500nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489940(US10966980, Example 194)
Affinity DataIC50: 0.00500nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM489974(US10966980, Example 228)
Affinity DataIC50: 0.00500nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

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