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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515335(CHEMBL4532589)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515320(CHEMBL4441630)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataEC50:  520nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515335(CHEMBL4532589)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614138(CHEMBL5283494)
Affinity DataIC50: 170nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 350nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50: 370nMAssay Description:Inhibition of BChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614131(CHEMBL5282788)
Affinity DataIC50: 538nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614129(CHEMBL5265814)
Affinity DataIC50: 756nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614146(CHEMBL5288465)
Affinity DataIC50: 860nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614141(CHEMBL5279473)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614132(CHEMBL5285633)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614139(CHEMBL5291438)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614140(CHEMBL5272119)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614146(CHEMBL5288465)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614135(CHEMBL5275394)
Affinity DataIC50: 3.55E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614130(CHEMBL5283557)
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614132(CHEMBL5285633)
Affinity DataIC50: 4.13E+3nMAssay Description:Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614134(CHEMBL5275931)
Affinity DataIC50: 4.44E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614144(CHEMBL5282158)
Affinity DataIC50: 4.56E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614138(CHEMBL5283494)
Affinity DataIC50: 5.11E+3nMAssay Description:Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614145(CHEMBL5270598)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614147(CHEMBL5272474)
Affinity DataIC50: 6.36E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614136(CHEMBL5287809)
Affinity DataIC50: 6.89E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614137(CHEMBL5281673)
Affinity DataIC50: 7.18E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614133(CHEMBL5284727)
Affinity DataIC50: 7.61E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614142(CHEMBL5285645)
Affinity DataIC50: 9.18E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614130(CHEMBL5283557)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614143(CHEMBL5283896)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as reduction in supercoiling of relaxed pBR322 DNA substrate after 30 mins by ethidium b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614145(CHEMBL5270598)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of BChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50506876(CHEMBL4580793)
Affinity DataIC50: 2.76E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as reduction in supercoiling of relaxed pBR322 DNA substrate after 30 mins by ethidium b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50506877(CHEMBL4545571)
Affinity DataIC50: 2.82E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as reduction in supercoiling of relaxed pBR322 DNA substrate after 30 mins by ethidium b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50506875(CHEMBL4443084)
Affinity DataIC50: 9.13E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as reduction in supercoiling of relaxed pBR322 DNA substrate after 30 mins by ethidium b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataKi:  0.000340nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515321(CHEMBL4543232)
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515320(CHEMBL4441630)
Affinity DataKi:  0.0420nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515326(CHEMBL4565381)
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515327(CHEMBL4556523)
Affinity DataKi:  0.0510nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515322(CHEMBL4444866)
Affinity DataKi:  0.106nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK243 cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515334(CHEMBL4581470)
Affinity DataKi:  0.196nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM21392([3H]-5-carboxamidotryptamine | CHEMBL18840 | 5-car...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK cell membrane incubated for 120 mins by microplate beta scintillation coun...More data for this Ligand-Target Pair
In DepthDetails
PubMed
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