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TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554691(CHEMBL4764318)
Affinity DataKi:  2.10nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nM ΔG°:  -50.5kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of [3H]-methyl-AdoMet binding to human phenylethnolamine N-methyltransferase expressed in E. coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyltransferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554692(CHEMBL4751862)
Affinity DataKi:  3.20nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554690(CHEMBL4782649)
Affinity DataKi:  3.30nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554695(CHEMBL4760727)
Affinity DataKi:  3.5nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554693(CHEMBL4800292)
Affinity DataKi:  3.80nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554689(CHEMBL4754656)
Affinity DataKi:  3.90nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50081952(((R)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-...)
Affinity DataKi:  4.90nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyltransferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM14061(8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine |...)
Affinity DataKi:  10nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyltransferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50100949((7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth...)
Affinity DataKi:  12nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50077544((S)-3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoli...)
Affinity DataKi:  16nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50174121(7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline | ...)
Affinity DataKi:  17nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50174121(7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline | ...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554685(CHEMBL4749263)
Affinity DataKi:  18nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor [16-465](Rat)
University of Queensland

LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/molepH: 7.7 T: 25°CAssay Description:The binding affinity of compound was evaluated using [3H] Clonidine as ligand in competition binding experiments. Nonspecific binding was determined ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13027(3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4...)
Affinity DataKi:  23nM ΔG°:  -45.4kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13027(3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4...)
Affinity DataKi:  23nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50240934(3-(hydroxymethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,...)
Affinity DataKi:  28nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554694(CHEMBL4740168)
Affinity DataKi:  38nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554681(CHEMBL4795252)
Affinity DataKi:  46nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50077537((+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)me...)
Affinity DataKi:  47nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13023(3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7...)
Affinity DataKi:  52nM ΔG°:  -43.2kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13023(3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7...)
Affinity DataKi:  52nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13023(3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50072977(7-Bromo-1,2,3,4-tetrahydro-isoquinoline | 7-bromo-...)
Affinity DataKi:  56nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50072977(7-Bromo-1,2,3,4-tetrahydro-isoquinoline | 7-bromo-...)
Affinity DataKi:  56nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554684(CHEMBL4796664)
Affinity DataKi:  57nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50163104((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)
Affinity DataKi:  61nMAssay Description:In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13025(7-sulfonamide-THIQ 15 | CHEMBL176112 | N-(4-chloro...)
Affinity DataKi:  63nM ΔG°:  -42.8kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM13025(7-sulfonamide-THIQ 15 | CHEMBL176112 | N-(4-chloro...)
Affinity DataKi:  63nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50227503(3-Methyl-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-c...)
Affinity DataKi:  67nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50186678((+/-)-3-difluoromethyl-7-trifluoromethyl-1,2,3,4-t...)
Affinity DataKi:  67nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50080520(3-Fluoromethyl-7-iodo-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataKi:  70nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyltransferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554682(CHEMBL4789060)
Affinity DataKi:  70nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554688(CHEMBL4791266)
Affinity DataKi:  71nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50077543(3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline |...)
Affinity DataKi:  72nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50163109((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)
Affinity DataKi:  72nMAssay Description:In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50077543(3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline |...)
Affinity DataKi:  72nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50554680(CHEMBL4791373)
Affinity DataKi:  86nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50100952(1-(2,3-Dichloro-phenyl)-ethylamine | 2,3-dichloro-...)
Affinity DataKi:  90nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyltransferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM14060(7-Iodo-1,2,3,4-tetrahydroisoquinoline | CHEMBL2682...)
Affinity DataKi:  93nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50186676((+/-)-3-difluoromethyl-7-bromo-1,2,3,4-tetrahydroi...)
Affinity DataKi:  94nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50163108((3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,...)
Affinity DataKi:  99nMAssay Description:In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50081954((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)
Affinity DataKi:  110nMAssay Description:In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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