Compile Data Set for Download or QSAR
Found 93 with Last Name = 'curzu' and Initial = 'mm'
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50216315((1R,4R)-2-(6-chloro-3-pyridinyl)-2,5-diazabicyclo[...)
Show SMILES Clc1ccc(cn1)N1CC2CC1CN2
Show InChI InChI=1S/C10H12ClN3/c11-10-2-1-8(4-13-10)14-6-7-3-9(14)5-12-7/h1-2,4,7,9,12H,3,5-6H2
Affinity DataKi:  0.0180nMAssay Description:Displacement of [3H]cytosine form alpha4beta2 nAChR in rat striatumMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275878(3-(6-chloropyridin-3-yl)-3,6-diazabicyclo[3.1.1]he...)
Show SMILES Clc1ccc(cn1)N1CC2CC(C1)N2
Show InChI InChI=1S/C10H12ClN3/c11-10-2-1-9(4-12-10)14-5-7-3-8(6-14)13-7/h1-2,4,7-8,13H,3,5-6H2
Affinity DataKi:  0.0230nMAssay Description:Displacement of [3H]epibatidine form alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275880(3-(6-bromopyridin-3-yl)-3,6-diazabicyclo[3.1.1]hep...)
Show SMILES Brc1ccc(cn1)N1CC2CC(C1)N2
Show InChI InChI=1S/C10H12BrN3/c11-10-2-1-9(4-12-10)14-5-7-3-8(6-14)13-7/h1-2,4,7-8,13H,3,5-6H2
Affinity DataKi:  0.0390nMAssay Description:Displacement of [3H]epibatidine form alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200169(6-methyl-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl...)
Show SMILES Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCC2)c1
Show InChI InChI=1S/C23H22Cl2N4O/c1-14-5-7-17-15(11-14)12-18-21(23(30)27-28-9-3-2-4-10-28)26-29(22(17)18)20-8-6-16(24)13-19(20)25/h5-8,11,13H,2-4,9-10,12H2,1H3,(H,27,30)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275879(3-(pyridin-3-yl)-3,6-diazabicyclo[3.1.1]heptane | ...)
Show SMILES C1C2CN(CC1N2)c1cccnc1
Show InChI InChI=1S/C10H13N3/c1-2-10(5-11-3-1)13-6-8-4-9(7-13)12-8/h1-3,5,8-9,12H,4,6-7H2
Affinity DataKi:  0.0560nMAssay Description:Displacement of [3H]epibatidine form alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275932(3-(6-chloropyridazin-3-yl)-3,6-diazabicyclo[3.1.1]...)
Show SMILES Clc1ccc(nn1)N1CC2CC(C1)N2
Show InChI InChI=1S/C9H11ClN4/c10-8-1-2-9(13-12-8)14-4-6-3-7(5-14)11-6/h1-2,6-7,11H,3-5H2
Affinity DataKi:  0.168nMAssay Description:Displacement of [3H]epibatidine form alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50180022(5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1...)
Show SMILES Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2C3(C)CCC(C3)C2(C)C)cc1
Show InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50176977(1,4-dihydroindeno[1,2-c]-pyrazole | 6-chloro-1-(2'...)
Show SMILES Clc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCC2)c1
Show InChI InChI=1S/C22H19Cl3N4O/c23-14-4-6-16-13(10-14)11-17-20(22(30)27-28-8-2-1-3-9-28)26-29(21(16)17)19-7-5-15(24)12-18(19)25/h4-7,10,12H,1-3,8-9,11H2,(H,27,30)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275933(3-(6-chloropyridin-3-yl)-6-methyl-3,6-diazabicyclo...)
Show SMILES CN1C2CC1CN(C2)c1ccc(Cl)nc1
Show InChI InChI=1S/C11H14ClN3/c1-14-9-4-10(14)7-15(6-9)8-2-3-11(12)13-5-8/h2-3,5,9-10H,4,6-7H2,1H3
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]epibatidine form alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Show SMILES CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1
Show InChI InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058435(CHEMBL3331463)
Show SMILES Cc1cc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCCC2)s1
Show InChI InChI=1S/C22H22Cl2N4OS/c1-13-10-15-19(30-13)12-16-20(22(29)26-27-8-4-2-3-5-9-27)25-28(21(15)16)18-7-6-14(23)11-17(18)24/h6-7,10-11H,2-5,8-9,12H2,1H3,(H,26,29)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275931(3-(4-nitrophenyl)-3,6-diazabicyclo[3.1.1]heptane |...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CC2CC(C1)N2
Show InChI InChI=1S/C11H13N3O2/c15-14(16)11-3-1-10(2-4-11)13-6-8-5-9(7-13)12-8/h1-4,8-9,12H,5-7H2
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]epibatidine form alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275879(3-(pyridin-3-yl)-3,6-diazabicyclo[3.1.1]heptane | ...)
Show SMILES C1C2CN(CC1N2)c1cccnc1
Show InChI InChI=1S/C10H13N3/c1-2-10(5-11-3-1)13-6-8-4-9(7-13)12-8/h1-3,5,8-9,12H,4,6-7H2
Affinity DataKi:  1.36nMAssay Description:Displacement of [3H]alpha-bungarotoxin form alpha7 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Show SMILES CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1
Show InChI InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058436(CHEMBL3331464)
Show SMILES Cc1cc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCC2)s1
Show InChI InChI=1S/C21H20Cl2N4OS/c1-12-9-14-18(29-12)11-15-19(21(28)25-26-7-3-2-4-8-26)24-27(20(14)15)17-6-5-13(22)10-16(17)23/h5-6,9-10H,2-4,7-8,11H2,1H3,(H,25,28)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058437(CHEMBL3329245)
Show SMILES Cc1csc2Cc3c(nn(Cc4ccc(C)cc4)c3-c12)C(=O)NC1[C@@]2(C)CCC(C2)C1(C)C
Show InChI InChI=1S/C28H33N3OS/c1-16-6-8-18(9-7-16)14-31-24-20(12-21-22(24)17(2)15-33-21)23(30-31)25(32)29-26-27(3,4)19-10-11-28(26,5)13-19/h6-9,15,19,26H,10-14H2,1-5H3,(H,29,32)/t19?,26?,28-/m0/s1
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058438(CHEMBL3329244)
Show SMILES CC(C)[C@H]1CC[C@H](C)CC1NC(=O)c1nn(Cc2ccc(C)cc2)c-2c1Cc1scc(C)c-21
Show InChI InChI=1S/C28H35N3OS/c1-16(2)21-11-8-18(4)12-23(21)29-28(32)26-22-13-24-25(19(5)15-33-24)27(22)31(30-26)14-20-9-6-17(3)7-10-20/h6-7,9-10,15-16,18,21,23H,8,11-14H2,1-5H3,(H,29,32)/t18-,21+,23?/m0/s1
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275878(3-(6-chloropyridin-3-yl)-3,6-diazabicyclo[3.1.1]he...)
Show SMILES Clc1ccc(cn1)N1CC2CC(C1)N2
Show InChI InChI=1S/C10H12ClN3/c11-10-2-1-9(4-12-10)14-5-7-3-8(6-14)13-7/h1-2,4,7-8,13H,3,5-6H2
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]alpha-bungarotoxin form alpha7 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058500(CHEMBL3331452)
Show SMILES CC(C)[C@H]1CC[C@H](C)CC1NC(=O)c1nn(Cc2ccc(C)cc2)c-2c1Cc1sc(C)cc-21
Show InChI InChI=1S/C28H35N3OS/c1-16(2)21-11-8-18(4)12-24(21)29-28(32)26-23-14-25-22(13-19(5)33-25)27(23)31(30-26)15-20-9-6-17(3)7-10-20/h6-7,9-10,13,16,18,21,24H,8,11-12,14-15H2,1-5H3,(H,29,32)/t18-,21+,24?/m0/s1
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058508(CHEMBL3331460)
Show SMILES CC(C)[C@H]1CC[C@H](C)CC1NC(=O)c1nn(c-2c1Cc1sc(C)cc-21)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H29Cl2N3OS/c1-13(2)17-7-5-14(3)9-21(17)29-26(32)24-19-12-23-18(10-15(4)33-23)25(19)31(30-24)22-8-6-16(27)11-20(22)28/h6,8,10-11,13-14,17,21H,5,7,9,12H2,1-4H3,(H,29,32)/t14-,17+,21?/m0/s1
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058501(CHEMBL3331453)
Show SMILES Cc1csc2Cc3c(nn(c3-c12)-c1ccc(Cl)cc1Cl)C(=O)NC1[C@@]2(C)CCC(C2)C1(C)C
Show InChI InChI=1S/C26H27Cl2N3OS/c1-13-12-33-19-10-16-21(23(32)29-24-25(2,3)14-7-8-26(24,4)11-14)30-31(22(16)20(13)19)18-6-5-15(27)9-17(18)28/h5-6,9,12,14,24H,7-8,10-11H2,1-4H3,(H,29,32)/t14?,24?,26-/m0/s1
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058508(CHEMBL3331460)
Show SMILES CC(C)[C@H]1CC[C@H](C)CC1NC(=O)c1nn(c-2c1Cc1sc(C)cc-21)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H29Cl2N3OS/c1-13(2)17-7-5-14(3)9-21(17)29-26(32)24-19-12-23-18(10-15(4)33-23)25(19)31(30-24)22-8-6-16(27)11-20(22)28/h6,8,10-11,13-14,17,21H,5,7,9,12H2,1-4H3,(H,29,32)/t14-,17+,21?/m0/s1
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse brain (minus cerebellum) CB1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058502(CHEMBL3331454)
Show SMILES CC(C)[C@H]1CC[C@H](C)CC1NC(=O)c1nn(c-2c1Cc1scc(C)c-21)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H29Cl2N3OS/c1-13(2)17-7-5-14(3)9-20(17)29-26(32)24-18-11-22-23(15(4)12-33-22)25(18)31(30-24)21-8-6-16(27)10-19(21)28/h6,8,10,12-14,17,20H,5,7,9,11H2,1-4H3,(H,29,32)/t14-,17+,20?/m0/s1
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058433(CHEMBL3331461)
Show SMILES Cc1cc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NC2CCCCC2)s1
Show InChI InChI=1S/C22H21Cl2N3OS/c1-12-9-15-19(29-12)11-16-20(22(28)25-14-5-3-2-4-6-14)26-27(21(15)16)18-8-7-13(23)10-17(18)24/h7-10,14H,2-6,11H2,1H3,(H,25,28)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200166(1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamin...)
Show SMILES Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C24H23Cl2N3O/c1-14-7-9-18-15(11-14)12-19-22(24(30)27-17-5-3-2-4-6-17)28-29(23(18)19)21-10-8-16(25)13-20(21)26/h7-11,13,17H,2-6,12H2,1H3,(H,27,30)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275933(3-(6-chloropyridin-3-yl)-6-methyl-3,6-diazabicyclo...)
Show SMILES CN1C2CC1CN(C2)c1ccc(Cl)nc1
Show InChI InChI=1S/C11H14ClN3/c1-14-9-4-10(14)7-15(6-9)8-2-3-11(12)13-5-8/h2-3,5,9-10H,4,6-7H2,1H3
Affinity DataKi:  20nMAssay Description:Displacement of [3H]alpha-bungarotoxin form alpha7 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200177(7-chloro-1-(2',4'-dichlorophenyl)-6-methyl-N-cyclo...)
Show SMILES Cc1cc2Cc3c(nn(c3-c2cc1Cl)-c1ccc(Cl)cc1Cl)C(=O)NC1CCCCC1
Show InChI InChI=1S/C24H22Cl3N3O/c1-13-9-14-10-18-22(24(31)28-16-5-3-2-4-6-16)29-30(23(18)17(14)12-19(13)26)21-8-7-15(25)11-20(21)27/h7-9,11-12,16H,2-6,10H2,1H3,(H,28,31)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275932(3-(6-chloropyridazin-3-yl)-3,6-diazabicyclo[3.1.1]...)
Show SMILES Clc1ccc(nn1)N1CC2CC(C1)N2
Show InChI InChI=1S/C9H11ClN4/c10-8-1-2-9(13-12-8)14-4-6-3-7(5-14)11-6/h1-2,6-7,11H,3-5H2
Affinity DataKi:  25nMAssay Description:Displacement of [3H]alpha-bungarotoxin form alpha7 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200163(1-(2',4'-dichlorophenyl)-6-methyl-N-phenyl-1,4-dih...)
Show SMILES Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C24H17Cl2N3O/c1-14-7-9-18-15(11-14)12-19-22(24(30)27-17-5-3-2-4-6-17)28-29(23(18)19)21-10-8-16(25)13-20(21)26/h2-11,13H,12H2,1H3,(H,27,30)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058434(CHEMBL3331462)
Show SMILES Cc1cc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCC2)s1
Show InChI InChI=1S/C20H18Cl2N4OS/c1-11-8-13-17(28-11)10-14-18(20(27)24-25-6-2-3-7-25)23-26(19(13)14)16-5-4-12(21)9-15(16)22/h4-5,8-9H,2-3,6-7,10H2,1H3,(H,24,27)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Università di Sassari

Curated by ChEMBL
LigandPNGBDBM50275880(3-(6-bromopyridin-3-yl)-3,6-diazabicyclo[3.1.1]hep...)
Show SMILES Brc1ccc(cn1)N1CC2CC(C1)N2
Show InChI InChI=1S/C10H12BrN3/c11-10-2-1-9(4-12-10)14-5-7-3-8(6-14)13-7/h1-2,4,7-8,13H,3,5-6H2
Affinity DataKi:  50.5nMAssay Description:Displacement of [3H]alpha-bungarotoxin form alpha7 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200175(1-(2',4'-dichlorophenyl)-6-methyl-N-p-fluorophenyl...)
Show SMILES Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C24H16Cl2FN3O/c1-13-2-8-18-14(10-13)11-19-22(24(31)28-17-6-4-16(27)5-7-17)29-30(23(18)19)21-9-3-15(25)12-20(21)26/h2-10,12H,11H2,1H3,(H,28,31)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200172(1-(2',4'-dichlorophenyl)-6-methyl-N-phenyl-1,4-dih...)
Show SMILES Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NNc2ccccc2)c1
Show InChI InChI=1S/C24H18Cl2N4O/c1-14-7-9-18-15(11-14)12-19-22(24(31)28-27-17-5-3-2-4-6-17)29-30(23(18)19)21-10-8-16(25)13-20(21)26/h2-11,13,27H,12H2,1H3,(H,28,31)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058498(CHEMBL3331450)
Show SMILES Cc1csc2Cc3c(nn(Cc4ccc(C)cc4)c3-c12)C(=O)NN1CCCCCC1
Show InChI InChI=1S/C24H28N4OS/c1-16-7-9-18(10-8-16)14-28-23-19(13-20-21(23)17(2)15-30-20)22(25-28)24(29)26-27-11-5-3-4-6-12-27/h7-10,15H,3-6,11-14H2,1-2H3,(H,26,29)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50180022(5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1...)
Show SMILES Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2C3(C)CCC(C3)C2(C)C)cc1
Show InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200167(1-(2',4'-dichlorophenyl)-6-methyl-N-p-methylphenyl...)
Show SMILES Cc1ccc(NC(=O)c2nn(c-3c2Cc2cc(C)ccc-32)-c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C25H19Cl2N3O/c1-14-3-7-18(8-4-14)28-25(31)23-20-12-16-11-15(2)5-9-19(16)24(20)30(29-23)22-10-6-17(26)13-21(22)27/h3-11,13H,12H2,1-2H3,(H,28,31)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200165(6-chloro-1-(2',4'-dichlorophenyl)-7-methyl-N-piper...)
Show SMILES Cc1cc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCC2)cc1Cl
Show InChI InChI=1S/C23H21Cl3N4O/c1-13-9-16-14(11-18(13)25)10-17-21(23(31)28-29-7-3-2-4-8-29)27-30(22(16)17)20-6-5-15(24)12-19(20)26/h5-6,9,11-12H,2-4,7-8,10H2,1H3,(H,28,31)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200171(1-(2',4'-dichlorophenyl)-6-methyl-N-p-methoxypheny...)
Show SMILES COc1ccc(NC(=O)c2nn(c-3c2Cc2cc(C)ccc-32)-c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C25H19Cl2N3O2/c1-14-3-9-19-15(11-14)12-20-23(25(31)28-17-5-7-18(32-2)8-6-17)29-30(24(19)20)22-10-4-16(26)13-21(22)27/h3-11,13H,12H2,1-2H3,(H,28,31)
Affinity DataKi:  114nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058499(CHEMBL3331451)
Show SMILES Cc1csc2Cc3c(nn(Cc4ccc(C)cc4)c3-c12)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H26N4OS/c1-15-6-8-17(9-7-15)13-27-22-18(12-19-20(22)16(2)14-29-19)21(24-27)23(28)25-26-10-4-3-5-11-26/h6-9,14H,3-5,10-13H2,1-2H3,(H,25,28)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058438(CHEMBL3329244)
Show SMILES CC(C)[C@H]1CC[C@H](C)CC1NC(=O)c1nn(Cc2ccc(C)cc2)c-2c1Cc1scc(C)c-21
Show InChI InChI=1S/C28H35N3OS/c1-16(2)21-11-8-18(4)12-23(21)29-28(32)26-22-13-24-25(19(5)15-33-24)27(22)31(30-26)14-20-9-6-17(3)7-10-20/h6-7,9-10,15-16,18,21,23H,8,11-14H2,1-5H3,(H,29,32)/t18-,21+,23?/m0/s1
Affinity DataKi:  160nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse brain (minus cerebellum) CB1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200162(1-(2',4'-dichlorophenyl)-6-methyl-N-p-chlorophenyl...)
Show SMILES Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H16Cl3N3O/c1-13-2-8-18-14(10-13)11-19-22(24(31)28-17-6-3-15(25)4-7-17)29-30(23(18)19)21-9-5-16(26)12-20(21)27/h2-10,12H,11H2,1H3,(H,28,31)
Affinity DataKi:  177nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058500(CHEMBL3331452)
Show SMILES CC(C)[C@H]1CC[C@H](C)CC1NC(=O)c1nn(Cc2ccc(C)cc2)c-2c1Cc1sc(C)cc-21
Show InChI InChI=1S/C28H35N3OS/c1-16(2)21-11-8-18(4)12-24(21)29-28(32)26-23-14-25-22(13-19(5)33-25)27(23)31(30-26)15-20-9-6-17(3)7-10-20/h6-7,9-10,13,16,18,21,24H,8,11-12,14-15H2,1-5H3,(H,29,32)/t18-,21+,24?/m0/s1
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse brain (minus cerebellum) CB1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058496(CHEMBL3331448)
Show SMILES Cc1csc2Cc3c(nn(Cc4ccc(C)cc4)c3-c12)C(=O)NC1CCCCC1
Show InChI InChI=1S/C24H27N3OS/c1-15-8-10-17(11-9-15)13-27-23-19(12-20-21(23)16(2)14-29-20)22(26-27)24(28)25-18-6-4-3-5-7-18/h8-11,14,18H,3-7,12-13H2,1-2H3,(H,25,28)
Affinity DataKi:  191nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200168(7-chloro-1-(2',4'-dichlorophenyl)-6-methyl-N-piper...)
Show SMILES Cc1cc2Cc3c(nn(c3-c2cc1Cl)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H21Cl3N4O/c1-13-9-14-10-17-21(23(31)28-29-7-3-2-4-8-29)27-30(22(17)16(14)12-18(13)25)20-6-5-15(24)11-19(20)26/h5-6,9,11-12H,2-4,7-8,10H2,1H3,(H,28,31)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(MOUSE)
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058506(CHEMBL3331458)
Show SMILES Cc1csc2Cc3c(nn(c3-c12)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCCC1
Show InChI InChI=1S/C22H22Cl2N4OS/c1-13-12-30-18-11-15-20(22(29)26-27-8-4-2-3-5-9-27)25-28(21(15)19(13)18)17-7-6-14(23)10-16(17)24/h6-7,10,12H,2-5,8-9,11H2,1H3,(H,26,29)
Affinity DataKi:  321nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse spleen CB2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50200169(6-methyl-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl...)
Show SMILES Cc1ccc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCC2)c1
Show InChI InChI=1S/C23H22Cl2N4O/c1-14-5-7-17-15(11-14)12-18-21(23(30)27-28-9-3-2-4-10-28)26-29(22(17)18)20-8-6-16(24)13-19(20)25/h5-8,11,13H,2-4,9-10,12H2,1H3,(H,27,30)
Affinity DataKi:  363nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058499(CHEMBL3331451)
Show SMILES Cc1csc2Cc3c(nn(Cc4ccc(C)cc4)c3-c12)C(=O)NN1CCCCC1
Show InChI InChI=1S/C23H26N4OS/c1-15-6-8-17(9-7-15)13-27-22-18(12-19-20(22)16(2)14-29-19)21(24-27)23(28)25-26-10-4-3-5-11-26/h6-9,14H,3-5,10-13H2,1-2H3,(H,25,28)
Affinity DataKi:  377nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse brain (minus cerebellum) CB1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058437(CHEMBL3329245)
Show SMILES Cc1csc2Cc3c(nn(Cc4ccc(C)cc4)c3-c12)C(=O)NC1[C@@]2(C)CCC(C2)C1(C)C
Show InChI InChI=1S/C28H33N3OS/c1-16-6-8-18(9-7-16)14-31-24-20(12-21-22(24)17(2)15-33-21)23(30-31)25(32)29-26-27(3,4)19-10-11-28(26,5)13-19/h6-9,15,19,26H,10-14H2,1-5H3,(H,29,32)/t19?,26?,28-/m0/s1
Affinity DataKi:  420nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse brain (minus cerebellum) CB1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058436(CHEMBL3331464)
Show SMILES Cc1cc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCC2)s1
Show InChI InChI=1S/C21H20Cl2N4OS/c1-12-9-14-18(29-12)11-15-19(21(28)25-26-7-3-2-4-8-26)24-27(20(14)15)17-6-5-13(22)10-16(17)23/h5-6,9-10H,2-4,7-8,11H2,1H3,(H,25,28)
Affinity DataKi:  440nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse brain (minus cerebellum) CB1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Universit£ di Sassari

Curated by ChEMBL
LigandPNGBDBM50058435(CHEMBL3331463)
Show SMILES Cc1cc-2c(Cc3c(nn(c-23)-c2ccc(Cl)cc2Cl)C(=O)NN2CCCCCC2)s1
Show InChI InChI=1S/C22H22Cl2N4OS/c1-13-10-15-19(30-13)12-16-20(22(29)26-27-8-4-2-3-5-9-27)25-28(21(15)16)18-7-6-14(23)11-17(18)24/h6-7,10-11H,2-5,8-9,12H2,1H3,(H,26,29)
Affinity DataKi:  442nMAssay Description:Displacement of [3H]-CP55940 from CD1 mouse brain (minus cerebellum) CB1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
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