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TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406539(CHEMBL4175573)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406539(CHEMBL4175573)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406688(CHEMBL4166620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406688(CHEMBL4166620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515335(CHEMBL4532589)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515320(CHEMBL4441630)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataEC50:  520nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515335(CHEMBL4532589)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50199769((S)-3-((4S,7S)-7-(isoquinoline-1-carboxamido)-6,10...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of caspase 1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCannabinoid receptor 1(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 9.70nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO cell membranes assessed as reduction in GTPgammaS binding after 30 mins by microbeta count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Istituto Di Farmacologia Traslazionale

Curated by ChEMBL
LigandPNGBDBM50198341(CHEMBL3948172)
Affinity DataIC50: 13nMAssay Description:Inhibition of telomerase activity in human MCF7 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Istituto Di Farmacologia Traslazionale

Curated by ChEMBL
LigandPNGBDBM50198341(CHEMBL3948172)
Affinity DataIC50: 13nMAssay Description:Inhibition of telomerase activity in human H125 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Istituto Di Farmacologia Traslazionale

Curated by ChEMBL
LigandPNGBDBM50198341(CHEMBL3948172)
Affinity DataIC50: 13nMAssay Description:Inhibition of telomerase activity in human HT-29 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Istituto Di Farmacologia Traslazionale

Curated by ChEMBL
LigandPNGBDBM50198341(CHEMBL3948172)
Affinity DataIC50: 13nMAssay Description:Inhibition of telomerase activity in human M14 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition mea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50152112(CHEMBL3780792)
Affinity DataIC50: 27nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptors expressed in human Chem4 cell membrane incubated for 30 mins by [35S]GTPgammaS binding ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50152111(CHEMBL3781178)
Affinity DataIC50: 51nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptors expressed in human Chem4 cell membrane incubated for 30 mins by [35S]GTPgammaS binding ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50152116(CHEMBL3781131)
Affinity DataIC50: 80nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptors expressed in human Chem4 cell membrane incubated for 30 mins by [35S]GTPgammaS binding ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50116907(CHEMBL3613097)
Affinity DataIC50: 171nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptor transfected in Chem4 cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50454100(CHEMBL4206866)
Affinity DataIC50: 182nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO cell membranes assessed as reduction in GTPgammaS binding after 30 mins by microbeta count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50454107(CHEMBL4218702)
Affinity DataIC50: 249nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO cell membranes assessed as reduction in GTPgammaS binding after 30 mins by microbeta count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50152102(CHEMBL3781781)
Affinity DataIC50: 294nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptors expressed in human Chem4 cell membrane incubated for 30 mins by [35S]GTPgammaS binding ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50454105(CHEMBL4205229)
Affinity DataIC50: 550nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO cell membranes assessed as reduction in GTPgammaS binding after 30 mins by microbeta count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50116909(CHEMBL3613101)
Affinity DataIC50: 1.82E+3nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptor transfected in Chem4 cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602638(CHEMBL5172568)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602636(CHEMBL5185782)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602629(CHEMBL5188863)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602639(CHEMBL5206575)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602635(CHEMBL5177960)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602640(CHEMBL5173761)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602627(CHEMBL5192491)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602637(CHEMBL5175204)
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602632(CHEMBL5208650)
Affinity DataIC50: 3.26E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602633(CHEMBL5173918)
Affinity DataIC50: 5.14E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602630(CHEMBL5178554)
Affinity DataIC50: 5.35E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602631(CHEMBL5191559)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602634(CHEMBL5197730)
Affinity DataIC50: 7.78E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602626(CHEMBL5181912)
Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50602628(CHEMBL5170698)
Affinity DataIC50: 9.41E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50216315((1R,4R)-2-(6-chloro-3-pyridinyl)-2,5-diazabicyclo[...)
Affinity DataKi:  0.0180nMAssay Description:Agonist activity at alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406803(CHEMBL4168511)
Affinity DataKi:  0.0200nMAssay Description:Agonist activity at alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50406472(CHEMBL4163848)
Affinity DataKi:  0.0225nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515321(CHEMBL4543232)
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515320(CHEMBL4441630)
Affinity DataKi:  0.0420nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50515326(CHEMBL4565381)
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  0.0450nMAssay Description:Agonist activity at alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0450nMAssay Description:Binding affinity to alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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