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TargetMetabotropic glutamate receptor 1(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu1 stably expressed in golden hamster AV12 cell membrane co-expressing Gq assessed as assessed as increase i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu5 stably expressed in golden hamster AV12 cell membrane co-expressing Gq assessed as assessed as increase i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as increase in forskolin-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu4 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu4 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as incr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >1.25E+4nMAssay Description:Agonist activity at recombinant human mGlu6 receptor expressed in hamster AV12 cells co-expressing EAAT1 assessed as induction of forskolin-stimulate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu5 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu6 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as incr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as increase in forskolin-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu7 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as induction of forskolin-sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataEC50:  1.77E+3nMAssay Description:Antagonist activity at human recombinant mGlu8 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as asse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434133(CHEMBL2381643)
Affinity DataIC50: 6.30nMAssay Description:Agonist activity at mGlu3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558768(CHEMBL4759992)
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataIC50: 7nMAssay Description:Agonist activity at mGlu2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 7.80nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as asse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434132(CHEMBL2381642)
Affinity DataIC50: 8.60nMAssay Description:Agonist activity at mGlu2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558772(CHEMBL4748699)
Affinity DataIC50: 9.80nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434132(CHEMBL2381642)
Affinity DataIC50: 11nMAssay Description:Agonist activity at mGlu3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558769(CHEMBL4746125)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204261(CHEMBL3969063)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558778(CHEMBL4778355)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204259(CHEMBL3913414)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204268(CHEMBL3977508)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558768(CHEMBL4759992)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558774(CHEMBL4780402)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204267(CHEMBL3939492)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204256(CHEMBL3948272)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558775(CHEMBL4776989)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204267(CHEMBL3939492)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50434133(CHEMBL2381643)
Affinity DataIC50: 23nMAssay Description:Agonist activity at mGlu2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204261(CHEMBL3969063)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204259(CHEMBL3913414)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Avenida De La Industria

LigandPNGBDBM6683({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 26nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2005
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558769(CHEMBL4746125)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558774(CHEMBL4780402)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataIC50: 28nMAssay Description:Agonist activity at mGlu3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558773(CHEMBL4757159)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Avenida De La Industria

LigandPNGBDBM6684({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 29nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2005
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204256(CHEMBL3948272)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Avenida De La Industria

LigandPNGBDBM6687(6-[(2-chloro-6-fluorophenyl)carbonyl]-3-[(2,6-difl...)
Affinity DataIC50: 33nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2005
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204258(CHEMBL3933829)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
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