Compile Data Set for Download or QSAR
Report error Found 168 with Last Name = 'dore' and Initial = 'a'
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113479(CHEMBL3603926 | US10246432, Example 22 | US1058411...)
Affinity DataIC50: 0.398nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataIC50: 0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113473(CHEMBL3603920 | US10246432, Example 1 | US10584111...)
Affinity DataIC50: 1.60nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113475(CHEMBL3603922 | US10246432, Example 18 | US1058411...)
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataIC50: 2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113478(CHEMBL3603925 | US10246432, Example 20 | US1058411...)
Affinity DataIC50: 3.20nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataIC50: 5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)
Affinity DataIC50: 5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50443085(Mavoglurant | AFQ056)
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113466(CHEMBL3603913 | US10246432, Example 13 | US1058411...)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113470(CHEMBL3603917)
Affinity DataIC50: 20nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113481(CHEMBL3603928)
Affinity DataIC50: 32nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50049925(CHEMBL3317682)
Affinity DataIC50: 40nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
LigandPNGBDBM50049931(CHEMBL3317688)
Affinity DataIC50: 40nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113469(CHEMBL3603916)
Affinity DataIC50: 40nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50049930(CHEMBL3317687)
Affinity DataIC50: 42nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
LigandPNGBDBM50334662(2-Methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
LigandPNGBDBM50049932(CHEMBL3317689)
Affinity DataIC50: 55nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113471(CHEMBL3603918)
Affinity DataIC50: 79nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50049926(CHEMBL3317683)
Affinity DataIC50: 170nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
LigandPNGBDBM50049929(CHEMBL3317686)
Affinity DataIC50: 190nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113480(CHEMBL3603927 | US10246432, Example 5 | US10584111...)
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50049927(CHEMBL3317684)
Affinity DataIC50: 220nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113341(CHEMBL3603907)
Affinity DataIC50: 398nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50049933(CHEMBL3317690)
Affinity DataIC50: 480nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
LigandPNGBDBM50049934(CHEMBL3317691)
Affinity DataIC50: 900nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
LigandPNGBDBM50049935(CHEMBL3317692)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50049928(CHEMBL3317685)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Mouse)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50200169(6-methyl-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl...)
Affinity DataKi:  0.0370nMAssay Description:Displacement of [3H]CP-55,940 from CB2 receptor in CD-1 mouse spleen homogenate after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50152234(N*5*-{2-[4-(2,4-Difluoro-phenyl)-piperazin-1-yl]-e...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50152234(N*5*-{2-[4-(2,4-Difluoro-phenyl)-piperazin-1-yl]-e...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50318701([(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,...)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM21190(CHEMBL113142 | 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM21190(CHEMBL113142 | 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50180022(5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]CP-55,940 from human frontal cortex CB2 receptor expressed in CHO cell membrane after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM154947(US9000029, 26)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
Displayed 1 to 50 (of 168 total ) | Next | Last >>
Jump to: