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TargetCollagenase 3(Human)
Novartis

LigandPNGBDBM30369(piperidinyl glycine derivative, 24f)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/mole IC50:  0.5nMpH: 7.5 T: 22°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
TargetCollagenase 3(Human)
Novartis

LigandPNGBDBM11863(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Affinity DataKi:  0.280nM ΔG°:  -54.0kJ/mole IC50:  0.300nMpH: 7.5 T: 22°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
TargetCollagenase 3(Human)
Novartis

LigandPNGBDBM30344(Cipemastat | Trocade)
Affinity DataKi:  0.530nM ΔG°:  -52.4kJ/mole IC50:  3.5nMpH: 7.5 T: 22°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Human)
Novartis

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  1.27nM ΔG°:  -50.3kJ/mole IC50:  1.90nMpH: 7.5 T: 22°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Human)
Novartis Pharmaceuticals

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  8nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Human)
Novartis Pharmaceuticals

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  20nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13122((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  23nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13133((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  28nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13121((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  29nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13127((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  31nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
Novartis Pharmaceuticals

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  33nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13126((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  34nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13119((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  36nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13100(2-[(2-cyclohexylethyl)(4-methoxybenzene)sulfonamid...)
Affinity DataKi:  38nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13135((2R,3S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-...)
Affinity DataKi:  39nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13141((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  42nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  43nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13134((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-3-cyc...)
Affinity DataKi:  44nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13137((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  46nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13131((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-3-(te...)
Affinity DataKi:  48nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13136(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Affinity DataKi:  50nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13088(2-[(4-butoxybenzene)(2-methylpropyl)sulfonamido]-N...)
Affinity DataKi:  58nM ΔG°:  -43.0kJ/molepH: 7.5 T: 37°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13091(2-{[4-(cyclohexylmethoxy)benzene](2-methylpropyl)s...)
Affinity DataKi:  61nM ΔG°:  -42.8kJ/molepH: 7.5 T: 37°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13099(2-[(cyclohexylmethyl)(4-methoxybenzene)sulfonamido...)
Affinity DataKi:  61nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13090(2-{[4-(hexyloxy)benzene](2-methylpropyl)sulfonamid...)
Affinity DataKi:  63nM ΔG°:  -42.8kJ/molepH: 7.5 T: 37°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13132(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Affinity DataKi:  65nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13095(CGS 27023A Analog 23 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  66nM ΔG°:  -42.6kJ/molepH: 7.5 T: 37°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13130((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-6-(di...)
Affinity DataKi:  69nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
Affinity DataKi:  70nM ΔG°:  -42.5kJ/molepH: 7.5 T: 37°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13111(CGS 27023A Analog 39 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  70nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13129(CGS 27023A Analog 61 | benzyl N-[(5R)-5-[benzyl(4-...)
Affinity DataKi:  70nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13120(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Affinity DataKi:  71nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13089(CGS 27023A Analog 17 | N-hydroxy-2-{[4-(3-methylbu...)
Affinity DataKi:  78nM ΔG°:  -42.2kJ/molepH: 7.5 T: 37°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13140((2R)-6-(dimethylamino)-N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  81nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13128((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  85nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  86nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13115(CGS 27023A Analog 43 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  90nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13125(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Affinity DataKi:  92nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13098(CGS 27023A Analog 26 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  94nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13104(2-{[(4-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  94nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13097(CGS 27023A Analog 25 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  100nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13105(CGS 27023A Analog 33 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  104nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13123((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  104nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13106(CGS 27023A Analog 34 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  107nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13114(CGS 27023A Analog 42 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  113nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13096(CGS 27023A Analog 24 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  125nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  133nM ΔG°:  -40.8kJ/molepH: 7.5 T: 37°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13116(CGS 27023A Analog 44 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  134nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13118((2S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Affinity DataKi:  141nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13112(CGS 27023A Analog 40 | N-hydroxy-2-[(4-methoxybenz...)
Affinity DataKi:  151nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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