Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 7277 with Last Name = 'du' and Initial = 'x'
TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642537(US20230414794, Compound S2)
Affinity DataKi:  0.0800nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50481609(CHEMBL610504)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229378((R)-N-(1-(3-(4-cyanophenyl)H-imidazo[1,2-a]pyridin...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-IP-10 from CXCR3 receptor expressed in human PBMC in RPMI-1640 buffer supplemented with 0.5% BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataKi:  3.53nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50481608(CHEMBL598081)
Affinity DataKi:  3.80nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50481605(CHEMBL598288)
Affinity DataKi:  4.10nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642538(US20230414794, Compound S3)
Affinity DataKi:  5.69nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642536(US20230414794, Compound S1)
Affinity DataKi:  5.96nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50481604(CHEMBL610505)
Affinity DataKi:  7.60nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50481606(CHEMBL598082)
Affinity DataKi:  16nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301397(CHEMBL571390 | [1-(4-Methyl-benzyl)-piperidin-4-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50481607(CHEMBL598083)
Affinity DataKi:  20nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301394(CHEMBL568892 | methyl 4-(4-(4-(hydroxydiphenylmeth...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22874(2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301391(1-[4-(4-methylphenyl)butyl]-alpha,alpha-diphenyl-4...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301393(1-[4-(4-methylcyclohexyl)butyl]alpha,alpha-dipheny...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301398(CHEMBL571391 | Diphenyl-[1-(2-p-tolyl-ethyl)-piper...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301396(CHEMBL572034 | Phenyl-[1-(4-p-tolyl-butyl)-piperid...)
Affinity DataKi:  121nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301399(CHEMBL570695 | Diphenyl-[1-(3-p-tolyl-propyl)-pipe...)
Affinity DataKi:  155nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301392(4-[4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]bu...)
Affinity DataKi:  203nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | 7-hydroxy-3-phe...)
Affinity DataKi:  470nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096001(7-Hydroxy-3-pyrazolo[1,5-a]pyridin-2-yl-chromen-2-...)
Affinity DataKi:  500nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017724(CHEMBL127508 | Diphenyl-piperidin-4-yl-methanol | ...)
Affinity DataKi:  659nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50040929(4,5-dianilinophthalimide | 5,6-bis(phenylamino)-1H...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642541(US20230414794, Comparative Compound DS3 | US202304...)
Affinity DataKi: >1.00E+3nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50122787(2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyr...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50040923(2-Methyl-5,6-bis-phenylamino-isoindole-1,3-dione |...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50079267(Congo Red | Direct red 28 | Kongorot | Sodium diph...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642541(US20230414794, Comparative Compound DS3 | US202304...)
Affinity DataKi: >1.00E+3nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642540(US20230414794, Comparative Compound DS2)
Affinity DataKi: >1.00E+3nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642539(US20230414794, Comparative Compound DS1)
Affinity DataKi: >1.00E+3nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50100134(2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50265450(2-oxo-2-phenylethyl 7-hydroxy-2-oxo-2H-chromene-3-...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096006(7-Hydroxy-3-(2-methyl-thiazol-4-yl)-chromen-2-one ...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301395(1-(4-p-Tolyl-butyl)-piperidine | CHEMBL571073)
Affinity DataKi:  3.20E+3nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096008(3-Acetyl-7-hydroxy-chromen-2-one | 3-acetyl-7-hydr...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095995(7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL E...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of MEK1 phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611953(CHEMBL5289716)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of human 11beta-HSD1 in liver microsome incubated for 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.0650nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515356((13E,14E,22R,24S)-12-amino-24,35- difluoro-4-oxa-7...)
Affinity DataIC50:  0.120nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
University of California

Curated by ChEMBL
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50:  0.200nMAssay Description:Observed inhibition activity against protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515377((13E,14E,22R,24S)-12-amino- 24,35-difluoro-4-oxa-7...)
Affinity DataIC50:  0.210nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515368((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...)
Affinity DataIC50:  0.210nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515357((13E,14E,22R,24S,5S)-12-amino-24,35-difluoro- 5-me...)
Affinity DataIC50:  0.220nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515367(US11098060, Example 26)
Affinity DataIC50:  0.230nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515365(US11098060, Example 23)
Affinity DataIC50:  0.230nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Displayed 1 to 50 (of 7277 total ) | Next | Last >>
Jump to: