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TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

LigandPNGBDBM419120(the N3 Compound | cmdc.202100576, 8d(N3) | acs.jme...)
Affinity DataEC50:  1.68E+4nMAssay Description:To further substantiate the enzymatic inhibition results in vitro, we evaluated whether these compounds could prevent viral replication in cell-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

LigandPNGBDBM178090(5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)nap...)
Affinity DataEC50:  4.67E+3nMAssay Description:To further substantiate the enzymatic inhibition results in vitro, we evaluated whether these compounds could prevent viral replication in cell-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257659(CHEMBL4104511)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human N-terminal HA-tagged CB2 receptor expressed in mouse AtT20 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257657(CHEMBL4097158)
Affinity DataEC50:  142nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257659(CHEMBL4104511)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257660(CHEMBL4073323)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257672(CHEMBL4067184)
Affinity DataEC50:  6.70E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257673(CHEMBL4087526)
Affinity DataEC50:  630nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257674(CHEMBL4066155)
Affinity DataEC50:  1.30E+4nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257675(CHEMBL4079650)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257660(CHEMBL4073323)
Affinity DataEC50:  59nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257676(CHEMBL4100174)
Affinity DataEC50:  630nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257607(CHEMBL4104806)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257677(CHEMBL4102381)
Affinity DataEC50:  500nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257678(CHEMBL4078111)
Affinity DataEC50:  38nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257679(CHEMBL4062303)
Affinity DataEC50:  180nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257673(CHEMBL4087526)
Affinity DataEC50:  31nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257675(CHEMBL4079650)
Affinity DataEC50:  62nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257680(CHEMBL4103902)
Affinity DataEC50:  82nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257681(CHEMBL4102975)
Affinity DataEC50:  85nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257682(CHEMBL4095228)
Affinity DataEC50:  720nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257701(CHEMBL4077571)
Affinity DataEC50:  150nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257702(CHEMBL4098592)
Affinity DataEC50:  270nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257703(CHEMBL4086064)
Affinity DataEC50:  7.13E+3nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257708(CHEMBL4064542)
Affinity DataEC50:  140nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257709(CHEMBL4102443)
Affinity DataEC50:  410nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257710(CHEMBL4101539)
Affinity DataEC50:  220nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257711(CHEMBL4083541)
Affinity DataEC50:  200nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257712(CHEMBL4073127)
Affinity DataEC50:  160nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257657(CHEMBL4097158)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as induction of Ca2+ flux after 10 mins by Fluor-4 AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257713(CHEMBL4079140)
Affinity DataEC50:  100nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257714(CHEMBL4071769)
Affinity DataEC50:  610nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257715(CHEMBL4060372)
Affinity DataEC50:  180nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257716(CHEMBL4069058)
Affinity DataEC50:  430nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257717(CHEMBL4079817)
Affinity DataEC50:  420nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257718(CHEMBL4097844)
Affinity DataEC50:  4.70E+3nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257659(CHEMBL4104511)
Affinity DataEC50:  59nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257659(CHEMBL4104511)
Affinity DataEC50:  34nMAssay Description:Agonist activity at rat CB1 receptor expressed in mouse AtT20 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257739(CHEMBL4088147)
Affinity DataEC50:  35nMAssay Description:Agonist activity at rat CB1 receptor expressed in mouse AtT20 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257739(CHEMBL4088147)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human N-terminal HA-tagged CB2 receptor expressed in mouse AtT20 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257740(CHEMBL4066866)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human N-terminal HA-tagged CB2 receptor expressed in mouse AtT20 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257740(CHEMBL4066866)
Affinity DataEC50:  35nMAssay Description:Agonist activity at rat CB1 receptor expressed in mouse AtT20 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257741(CHEMBL4090311)
Affinity DataEC50:  410nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257674(CHEMBL4066155)
Affinity DataEC50:  160nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257742(CHEMBL2098107 | GW611920X | TCMDC-142478)
Affinity DataEC50:  980nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257743(CHEMBL4080556)
Affinity DataEC50:  75nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257744(CHEMBL4078172)
Affinity DataEC50:  490nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257745(CHEMBL4093817)
Affinity DataEC50:  3.80E+3nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257746(CHEMBL4098779)
Affinity DataEC50:  410nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50257756(CHEMBL4082277)
Affinity DataEC50:  92nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of CP55940-induced Ca2+ flux preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
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