Compile Data Set for Download or QSAR
Found 99 with Last Name = 'durant' and Initial = 'f'
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50119657(8-Butyl-7-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50089990(2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  25nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50119658(7-Butyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  80nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50121688(3-Methyl-8-(4,4,4-trifluoro-butoxy)-indeno[1,2-c]p...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50121685(5-(4,4,4-Trifluoro-butoxy)-indan-1-one | CHEMBL414...)
Affinity DataIC50:  0.318nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  1.10nMAssay Description:In vitro functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETB receptors)More data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
Facultés Universitaires N.D. de la Paix

Curated by ChEMBL
LigandPNGBDBM50098926(1-(2-Cyclohexylamino-5-nitro-benzenesulfonyl)-3-pe...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory concentration of compound against thromboxane A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50029815(3-[5-(4-Benzyloxy-phenyl)-tetrazol-2-yl]-propionit...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50029825(3-[5-(4-Benzyloxy-phenyl)-2-oxo-[1,3,4]oxadiazol-3...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  2.70nMAssay Description:Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovir...More data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Facultés Universitaires N.D. de la Paix

Curated by ChEMBL
LigandPNGBDBM50075624(6-{3-[1-(tert-butylamino)-2-cyano-(E)-1-iminomethy...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory concentration of compound against thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50029838(3-[5-(4-Benzyloxy-phenyl)-2-thioxo-[1,3,4]oxadiazo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-5 subunit in spinal cordMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50047034(3-[5-(4-Benzyloxy-phenyl)-2-oxo-[1,3,4]thiadiazol-...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50121686(5-(4,4,4-Trifluoro-butoxy)-indan-1,2,3-trione | CH...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Facultés Universitaires N.D. de la Paix

Curated by ChEMBL
LigandPNGBDBM50075624(6-{3-[1-(tert-butylamino)-2-cyano-(E)-1-iminomethy...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory concentration of compound against thromboxane A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-1 subunit in cerebellumMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50047022(3-[5-(4-Benzyloxy-phenyl)-2-thioxo-[1,3,4]thiadiaz...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50121687(3-[2-(4-Benzyloxy-phenyl)-6-oxo-5,6-dihydro-[1,3,4...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50121689(3-[2-Acetyl-4-(3-trifluoromethyl-benzyloxy)-phenox...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156581(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  36nMAssay Description:Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  36nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  45nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataIC50:  46nMAssay Description:Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  83nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM50031048(3-(4-(trifluoromethyl)phenyl)-5H-indeno[1,2-c]pyri...)
Affinity DataIC50:  90nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156577(1-(4-aminosulfonylphenyl)-3-[3-fluoro-5-(4-methoxy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataIC50:  130nMAssay Description:Compound was evaluated for in vitro functional inhibitory potency for prevention of sarafotoxin S6c induced constriction of rat tracheal rings (ETB r...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Facultés Universitaires Notre-Dame de la Paix

Curated by ChEMBL
LigandPNGBDBM19163(3-methyl-5H-indeno[1,2-c]pyridazin-5-one | Aza-het...)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against Monoamine oxidase B was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156584(1-(4-methanesulfonylphenyl)-3-[(3,4,5-trimethoxy)p...)
Affinity DataIC50:  220nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156581(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  300nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  300nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156594(3-[(3-fluoro-5-methoxy)phenoxymethyl]-1-(4-methane...)
Affinity DataIC50:  310nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50120981(1,1,1-trifluoro-N-(3-phenoxypyridin-4-yl)methanesu...)
Affinity DataIC50:  400nMAssay Description:The inhibitory activity against cyclooxygenase Prostaglandin G/H synthase 2 (COX-2) measured as PGE-2 production after blood coagulation using human ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156580(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  410nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Rattus norvegicus (Rat))
Centre de Neurochimie du CNRS

Curated by ChEMBL
LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...)
Affinity DataIC50:  420nMAssay Description:Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptorMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156590(1-(4-methanesulfonylphenyl)-3-[(3,4-methylenedioxy...)
Affinity DataIC50:  450nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156585(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  480nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156587(3-[(5-cyano-3-fluoro)phenoxymethyl]-1-(4-methanesu...)
Affinity DataIC50:  570nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156582(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  570nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156582(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  610nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156583(1-(4-methanesulfonylphenyl)-3-[(3,4-dimethoxy)phen...)
Affinity DataIC50:  700nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156579(1-(3,4-dichlorophenyl)-3-[3-fluoro-5-(4-methoxytet...)
Affinity DataIC50:  700nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156586(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  720nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156577(1-(4-aminosulfonylphenyl)-3-[3-fluoro-5-(4-methoxy...)
Affinity DataIC50:  740nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156591(1-(4-methanesulfonylphenyl)-3-[(3-nitro)phenoxymet...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156580(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  760nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50156581(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  770nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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