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TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113782((10R,13S,17S)-17-hydroxy-13-methyl-10-(4-methylben...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113783((2R,4aS,10aR)-4a-benzyl-2-(chloroethynyl)-1,2,3,4,...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113780((2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315763((4bS,7R,8aR)-4b-benzyl-7-hydroxy-7-(prop-1-ynyl)-N...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50124614(5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315767((S)-5-allyl-9-(ethynyloxy)-10-methoxy-2,2,4-trimet...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50113777((4aS,10aR)-4a-benzyl-7-hydroxy-3,4,4a,9,10,10a-hex...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315765((S)-5-allyl-10-ethynyl-2,2,4-trimethyl-2,5-dihydro...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315766((S)-9-methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM13775((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315764((S)-5-allyl-9-cyanato-10-methoxy-2,2,4-trimethyl-2...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049508(5-Bromo-4-methoxy-2-((1S,4R)-2,2,4-trimethyl-6-met...)
Affinity DataKi:  1.04E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344448(2-(1-(4-chlorobenzyl)-1H-benzo[d]imidazol-2-ylthio...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344444(3-amino-4-(4-(benzyloxy)-3-methoxyphenyl)-N-(5-chl...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049509((R)-5-bromo-2-((2,2-dimethyl-6-methylenecyclohexyl...)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344447(CHEMBL1780016 | methyl-5-(diethylcarbamoyl)-4-meth...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049506(5-Bromo-2-((1S,3R)-3-bromo-2,2-dimethyl-6-methylen...)
Affinity DataKi:  2.47E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50049497(5-Bromo-2-((1R,3R)-3-bromo-2,2-dimethyl-6-methylen...)
Affinity DataKi:  3.21E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344449(CHEMBL1780018 | ethyl 4-(5-(4-tert-butylbenzyliden...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50315768(5-bromo-4-methoxy-2-(((1S)-2,2,5-trimethyl-6-methy...)
Affinity DataKi:  4.11E+3nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344450(1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((8-methyl-2-...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344446(CHEMBL1699130 | dimethyl-4,4'-(ethane-1,2-diylbis(...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344445(CHEMBL1780014 | N-(3-(1-(2-(2-(3-butoxyphenyl)quin...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasmepsin II(Plasmodium falciparum)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50344451((S)-N5-(1-(1H-indol-3-yl)-2-(isopentylamino)-2-oxo...)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu- Ser-Phe-Pro-EDANS fluorogenic substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459859(CHEMBL4228617)
Affinity DataIC50:  0.550nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459856(CHEMBL4227113)
Affinity DataIC50:  0.940nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459863(CHEMBL4225078)
Affinity DataIC50:  1.20nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ER-alpha (unknown origin) by Lanthascreen-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459852(CHEMBL4228923)
Affinity DataIC50:  2.40nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ER-beta (unknown origin) by Lanthascreen-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459850(CHEMBL4224880)
Affinity DataIC50:  3.10nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459850(CHEMBL4224880)
Affinity DataIC50:  4.10nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50238736(CHEMBL1091535 | GW7604)
Affinity DataIC50:  4.40nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  5.60nMAssay Description:Displacement of Fluormone ES2 Green from full-length estrogen receptor beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  5.70nMAssay Description:Displacement of Fluormone ES2 Green from full-length estrogen receptor alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50238736(CHEMBL1091535 | GW7604)
Affinity DataIC50:  6.80nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459858(CHEMBL4225156)
Affinity DataIC50:  9.80nMAssay Description:Antagonist activity at estrogen receptor alpha/beta in human Ishikawa cells after 72 hrs by alkaline phosphatase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50276802(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at estrogen receptor alpha/beta in human Ishikawa cells after 72 hrs by alkaline phosphatase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  11.4nMAssay Description:Displacement of fluoromone from human glucocorticoid receptor LBD assessed as reduction of maximum polarization by fluorescence polarization assay re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459856(CHEMBL4227113)
Affinity DataIC50:  12nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459854(CHEMBL4225102)
Affinity DataIC50:  14nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459860(CHEMBL4228649)
Affinity DataIC50:  14nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459862(CHEMBL4228388)
Affinity DataIC50:  21nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459849(CHEMBL4229221)
Affinity DataIC50:  23nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50459854(CHEMBL4225102)
Affinity DataIC50:  25nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50276802(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  26nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50276802(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  26nMAssay Description:Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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