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TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498024(CHEMBL3326332)
Affinity DataIC50: 73nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498018(CHEMBL3326331)
Affinity DataIC50: 97nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 850nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235471(CHEMBL4062596)
Affinity DataIC50: 860nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235473(CHEMBL4072263)
Affinity DataIC50: 870nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235476(CHEMBL4085285)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498026(CHEMBL3326319)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235478(CHEMBL4100337)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235470(CHEMBL4090564)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235461(CHEMBL4074061)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235472(CHEMBL4063665)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235475(CHEMBL4100741)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498028(CHEMBL3326325)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235464(CHEMBL4095113)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022668(CHEMBL3299149)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235462(CHEMBL4087424)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235480(CHEMBL4079542)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235469(CHEMBL4082744)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235468(CHEMBL4073585)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498030(CHEMBL3326326)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022667(CHEMBL3299051)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235467(CHEMBL4094213)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235474(CHEMBL4090167)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50108771(2-(2-Amino-3-methoxy-phenyl)-chromen-4-one | PD-98...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235465(CHEMBL4068738)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235477(CHEMBL4093024)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235460(CHEMBL4068147)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235479(CHEMBL4089846)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235463(CHEMBL4067698)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235466(CHEMBL4097575)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498029(CHEMBL3326323)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50235459(CHEMBL4079020)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498027(CHEMBL3326329)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498025(CHEMBL3326324)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498023(CHEMBL3326330)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498022(CHEMBL3326328)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498021(CHEMBL3326327)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498020(CHEMBL3326320)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498019(CHEMBL3326322)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed