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TargetEukaryotic translation initiation factor 4E(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50613700(CHEMBL1234303 | CHEBI:50226)
Affinity DataKd:  370nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50613701(CHEMBL1232939 | CHEBI:17825)
Affinity DataKd:  3.90E+3nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50613702(CHEMBL5282449)
Affinity DataKd:  5.65E+4nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic translation initiation factor 4E(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50613703(CHEMBL5286550)
Affinity DataKd:  1.33E+5nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50613704(CHEMBL5283082)
Affinity DataKd:  5.78E+4nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432703(CHEMBL2348217)
Affinity DataKd:  27nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432704(CHEMBL2348218)
Affinity DataKd:  1nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432705(CHEMBL2348219)
Affinity DataKd:  2.80nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25768(ICI 118,551 | 1-[(7-methyl-2,3-dihydro-1H-inden-4-...)
Affinity DataKd:  0.676nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432706(CHEMBL2348220)
Affinity DataKd:  18nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25768(ICI 118,551 | 1-[(7-methyl-2,3-dihydro-1H-inden-4-...)
Affinity DataKd:  240nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432701(CHEMBL2348201)
Affinity DataKd:  794nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027871(CHEMBL2348216)
Affinity DataKd:  891nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027873(CHEMBL2348214)
Affinity DataKd:  1.59E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027872(CHEMBL2348215)
Affinity DataKd:  1.18E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  81nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432704(CHEMBL2348218)
Affinity DataKd:  1.23E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432705(CHEMBL2348219)
Affinity DataKd:  3.55E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  1.74E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432701(CHEMBL2348201)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432702(CHEMBL2348211)
Affinity DataKd:  3.5nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25746(cid_2685 | 2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-meth...)
Affinity DataKd:  60nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of CGP12177-induced [3H]cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25746(cid_2685 | 2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-meth...)
Affinity DataKd:  1.05E+3nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432703(CHEMBL2348217)
Affinity DataKd: >1.00E+4nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432704(CHEMBL2348218)
Affinity DataKd:  891nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432705(CHEMBL2348219)
Affinity DataKd:  1.45E+3nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432700(AB-A-663 | AC-263780 | CIMATEROL)
Affinity DataEC50:  7.40nMAssay Description:Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432706(CHEMBL2348220)
Affinity DataKd:  7.08E+3nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432707(LK-204-545 | LK-204545)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25746(cid_2685 | 2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-meth...)
Affinity DataKd:  1.60nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432702(CHEMBL2348211)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432701(CHEMBL2348201)
Affinity DataKd:  1.5nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432706(CHEMBL2348220)
Affinity DataKd:  32nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432705(CHEMBL2348219)
Affinity DataKd:  7.40nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432704(CHEMBL2348218)
Affinity DataKd:  3.20nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432703(CHEMBL2348217)
Affinity DataKd:  91nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027871(CHEMBL2348216)
Affinity DataKd:  17nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027872(CHEMBL2348215)
Affinity DataKd:  95nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50027873(CHEMBL2348214)
Affinity DataKd:  17nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25748(ICI 89,406 | 3-(2-{[3-(2-cyanophenoxy)-2-hydroxypr...)
Affinity DataKd:  0.331nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  18nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataEC50:  11nMAssay Description:Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25748(ICI 89,406 | 3-(2-{[3-(2-cyanophenoxy)-2-hydroxypr...)
Affinity DataEC50:  0.813nMAssay Description:Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432702(CHEMBL2348211)
Affinity DataKd:  1.20E+3nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25746(cid_2685 | 2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-meth...)
Affinity DataKd:  1.51E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432706(CHEMBL2348220)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432704(CHEMBL2348218)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432705(CHEMBL2348219)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432703(CHEMBL2348217)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50432707(LK-204-545 | LK-204545)
Affinity DataKd:  2.88E+3nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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