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TargetAcetylcholinesterase(Electric eel)
The Ohio State University-Marion

Curated by ChEMBL
LigandPNGBDBM50465496(CHEMBL4287206)
Affinity DataEC50:  1.21E+6nMAssay Description:Resurrection of methylphosphonate-aged electric eel AChE assessed as enzyme reactivation using acetylthiocholine as substrate at pH 9 after 1 day by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
The Ohio State University-Marion

Curated by ChEMBL
LigandPNGBDBM50465496(CHEMBL4287206)
Affinity DataEC50:  1.02E+6nMAssay Description:Resurrection of isopropyl phosphate-aged electric eel AChE assessed as enzyme reactivation using acetylthiocholine as substrate at pH 9 after 1 day b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  141nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334438((R)-7-oxo-N-(quinuclidin-3-yl)-4,7-dihydrothieno[3...)
Affinity DataEC50:  9.20nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334439(CHEMBL1643883 | US8501729, 12 | (R)-2-methyl-7-(qu...)
Affinity DataEC50:  6.90nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  178nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334438((R)-7-oxo-N-(quinuclidin-3-yl)-4,7-dihydrothieno[3...)
Affinity DataEC50:  5.40nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334440(US8501729, 16 | CHEMBL1643881 | (R)-7-(quinuclidin...)
Affinity DataEC50:  14.5nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334439(CHEMBL1643883 | US8501729, 12 | (R)-2-methyl-7-(qu...)
Affinity DataEC50:  12.6nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(CHEMBL1094231 | 1-(3-chloro-4-fluorophenyl)-2,2,2-...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316567(1-(2-chloropyridin-4-yl)-2,2,2-trifluoro-1-(1-(4-f...)
Affinity DataEC50:  627nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(CHEMBL1096467 | CHEMBL1094536 | 2-chloro-4-(2,2,2-...)
Affinity DataEC50:  112nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316569(2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316566(1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-flu...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(CHEMBL1094231 | 1-(3-chloro-4-fluorophenyl)-2,2,2-...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316566(1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-flu...)
Affinity DataEC50:  350nMAssay Description:Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  55nMAssay Description:Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 7nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50019139(CHEMBL3288755)
Affinity DataIC50: 11nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316567(1-(2-chloropyridin-4-yl)-2,2,2-trifluoro-1-(1-(4-f...)
Affinity DataIC50: 14nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50019140(CHEMBL3288756)
Affinity DataIC50: 24nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(CHEMBL1096467 | CHEMBL1094536 | 2-chloro-4-(2,2,2-...)
Affinity DataIC50: 30nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: 33nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316565(1-(2-chlorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorop...)
Affinity DataIC50: 35nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316558(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5...)
Affinity DataIC50: 52nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316564(2,2,2-trifluoro-1-(2-fluorophenyl)-1-(1-(4-fluorop...)
Affinity DataIC50: 54nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(CHEMBL1096467 | CHEMBL1094536 | 2-chloro-4-(2,2,2-...)
Affinity DataIC50: 54nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316569(2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...)
Affinity DataIC50: 59nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316559(1-(3-chlorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorop...)
Affinity DataIC50: 72nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104496(US8575114, I-8)
Affinity DataIC50: 80nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104489(US8575114, I-1)
Affinity DataIC50: 83nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316555(2,2,2-trifluoro-1-(4-fluorophenyl)-1-[1-(4-fluorop...)
Affinity DataIC50: 86nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316555(2,2,2-trifluoro-1-(4-fluorophenyl)-1-[1-(4-fluorop...)
Affinity DataIC50: 86nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316566(1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-flu...)
Affinity DataIC50: 87nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316566(1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-flu...)
Affinity DataIC50: 87nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104492(US8575114, I-4)
Affinity DataIC50: 89nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316560(3-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazo...)
Affinity DataIC50: 99nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104498(US8575114, I-10)
Affinity DataIC50: 107nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104497(US8575114, I-9)
Affinity DataIC50: 110nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(CHEMBL1094231 | 1-(3-chloro-4-fluorophenyl)-2,2,2-...)
Affinity DataIC50: 117nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(CHEMBL1094231 | 1-(3-chloro-4-fluorophenyl)-2,2,2-...)
Affinity DataIC50: 117nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104490(US8575114, I-2)
Affinity DataIC50: 120nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104494(US8575114, I-6)
Affinity DataIC50: 141nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50316557(1-(3,4-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-flu...)
Affinity DataIC50: 178nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50329725((S)-2-(2-methoxyphenyl)-N-(quinuclidin-8-yl)benzo[...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human ERG expressed in HEK cells by patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM50329728(endo-2-cyclopropyl-N-((1R,5R)-9-methyl-9-azabicycl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human ERG expressed in HEK cells by patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM104499(US8575114, I-11)
Affinity DataIC50: 222nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50019138(CHEMBL3288754)
Affinity DataIC50: 248nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
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